Determinants of hyperuricemia in non-dialysed chronic kidney disease patients in three hospitals in Cameroon

Doualla, Marie Solange; Halle, Marie Patrice; Moutchia, Jude; Tegang, Steve; Ashuntantang, Gloria

doi:10.1186/s12882-018-0959-5

Cited by 12 publications

(12 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…IR can also promote HUA because hyperinsulinemia reduces the activity of 3-phosphoglycerate dehydrogenase, a key glycolytic enzyme, which leads to the conversion of glycolytic intermediates to 5-phosphate ribose and phosphoribose pyrophosphate, thereby promoting UA generation. In addition, IR promotes the accumulation of liver fat, which impairs purine metabolism, leading to the production of UA ( 27 , 28 ). These data linking HUA to IR suggest that SUA may be an independent predictor of HUA.…”

Section: Discussionmentioning

confidence: 99%

Resveratrol affects the expression of uric acid transporter by improving inflammation

et al. 2021

View full text Add to dashboard Cite

Resveratrol (RSV), a polyphenol, non-flavonoid plant-derived antitoxin, ameliorates hyperuricemia and kidney inflammation. The present study aimed to establish a model of high-fat diet (HFD)-induced insulin resistance (IR) and to determine the specific mechanism of RSV to improve kidney inflammation and reduce uric acid (UA). C57BL/6J mice were fed a HFD for 12 weeks and their glucose tolerance was evaluated by intraperitoneal glucose tolerance testing. The mice were then administered RSV for 6 weeks, and blood and kidney samples were collected. Serum UA and insulin concentrations were determined using ELISA kits. Hematoxylin and eosin, periodic acid-Schiff and Masson staining were performed to observe the pathological changes of the kidney, and electron microscopy was used to observe changes in the kidney ultrastructure. The renal concentrations of interleukin (IL)-6, IL-18, IL-1β and tumor necrosis factor-α (TNF-α) were measured using ELISA kits, and western blotting evaluated changes in the protein expression levels of various indicators. RSV significantly ameliorated HFD-induced IR and reduced blood UA levels. Long-term IR can lead to lipid deposition, glycogen accumulation, inflammatory damage and fibrotic changes in the kidney of mice. This leads to a significant increase in the expression of UA transport-related proteins, an increase in UA reabsorption and an increase in blood UA levels. Notably, RSV intervention was able to reverse this process. The effect of RSV may be achieved by inhibiting the NOD-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome and Toll-like receptor 4 (TLR4)/myeloid differentiation factor 88/nuclear factor-κB signaling pathway. In conclusion, RSV may improve kidney inflammation through TLR4 and NLRP3 signaling pathways, and reduce the expression of UA transporter proteins in the kidney of insulin-resistant mice, thereby reducing blood UA levels.

show abstract

Section: Discussionmentioning

confidence: 99%

Resveratrol affects the expression of uric acid transporter by improving inflammation

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Additionally, hyperuricemia was identi ed in non-dialyzed CKD patients followed in referral centers and as a factor of progression of CKD [47]. Bruggeman et al [58] discussed the mechanism of viral replication in CKD patients, implying viral infections as a comorbid condition in CKD.…”

Section: Discussionmentioning

confidence: 99%

Chronic Kidney Disease in Cameroon: A scoping review

Aseneh¹,

Kemah²,

Mabouna³

et al. 2020

Preprint

View full text Add to dashboard Cite

ObjectivesThis scoping review sought to summarize available data on the prevalence, associated factors, etiology, comorbidities, treatment, cost, and mortality of chronic kidney disease (CKD) in Cameroon.MethodsWe searched PubMed, Scopus and African Journals Online from database inception to 31 March, 2020 to identify all studies published on the prevalence, associated factors, etiology, comorbidities, treatment, cost and mortality of CKD in Cameroon.ResultsThirty studies were included. The population prevalence of CKD varied from 3-14.1% and 10.0%-14.2% in rural and urban areas, respectively. The prevalence of CKD in patients with hypertension, diabetes mellitus, and human immunodeficiency virus was 12.4-50.0%, 18.5%, and 3.0-47.2%, respectively. Hypertension (22.3-59.1%), chronic glomerulonephritis (15.8-56.2%), and diabetes mellitus (15.8-56.2%) were the most common causes of CKD. The cause was unknown in 13.5-17.0% of the cases. Advanced age, hypertension, diabetes mellitus, and obesity were frequent associated factors. Hemodialysis was the main treatment modality in patients with End Stage Renal Disease (ESRD). The monthly cost of management of non-dialyzed CKD was 163 US dollars. The one-year mortality rate of ESRD was 26.8-38.6%.ConclusionChronic kidney disease in affects about one in ten adults in the general population in Cameroon Patients with hypertension, diabetes mellitus, and human immunodeficiency virus bear the greatest burden of CKD in Cameroon. Advanced age, hypertension, diabetes mellitus, and obesity are major factors associated with CKD. Chronic kidney disease in Cameroon is associated with high morbidity and mortality and huge economic cost on the patient.

show abstract

“…Cardiovascular diseases were twice more common among CKD patients compared to the general population and advances at twice the rate [ 56 ]. Additionally, hyperuricemia was identified in non-dialyzed CKD patients followed in referral centers and as a factor of progression of CKD [ 47 ].…”

Section: Discusssionmentioning

confidence: 99%

Chronic kidney disease in Cameroon: a scoping review

Aseneh

Kemah

Mabouna³

et al. 2020

BMC Nephrol

View full text Add to dashboard Cite

Objectives This scoping review sought to summarize available data on the prevalence, associated factors, etiology, comorbidities, treatment, cost and mortality of chronic kidney disease (CKD) in Cameroon. Methods We searched PubMed, Scopus and African Journals Online from database inception to 31 March, 2020 to identify all studies published on the prevalence, associated factors, etiology, comorbidities, treatment, cost and mortality of CKD in Cameroon. Results Thirty studies were included. The prevalence of CKD varied from 3 to 14.1 and 10.0%–14.2% in rural and urban areas, respectively. The prevalence of CKD in patients with hypertension, diabetes mellitus, and human immunodeficiency virus was 12.4–50.0, 18.5%, and 3.0–47.2%, respectively. Hypertension (22.3–59.1%), chronic glomerulonephritis (15.8–56.2%), and diabetes mellitus (15.8–56.2%) were the most common causes of CKD. The cause was unknown in 13.5–17.0% of the cases. Advanced age, hypertension, diabetes mellitus, and obesity were frequent associated factors. Hemodialysis was the main treatment modality in patients with End Stage Renal Disease (ESRD). The monthly cost of management of non-dialyzed CKD was 163 US dollars. The one-year mortality rate of ESRD was 26.8–38.6%. Conclusion Chronic kidney disease affects about one in 10 adults in the general population in Cameroon. Patients with hypertension, diabetes mellitus, and human immunodeficiency virus bear the greatest burden of CKD in Cameroon. Advanced age, hypertension, diabetes mellitus, and obesity are major factors associated with CKD. Chronic kidney disease in Cameroon is associated with high morbidity and mortality and huge economic cost on the patient.

show abstract

Determinants of hyperuricemia in non-dialysed chronic kidney disease patients in three hospitals in Cameroon

Cited by 12 publications

References 50 publications

Resveratrol affects the expression of uric acid transporter by improving inflammation

Resveratrol affects the expression of uric acid transporter by improving inflammation

Chronic Kidney Disease in Cameroon: A scoping review

Chronic kidney disease in Cameroon: a scoping review

Contact Info

Product

Resources

About