Determinants and Interactions of Oral Bacterial and Fungal Microbiota in Healthy Chinese Adults

Cheung, Man Kit; Chan, Jason Y. K.; Wong, Martin Cs; Wong, Pak-Kin; Liao, Pu; Cai, Liuyang; Lan, Linda; Ho, Walter K.K.; Yeung, Albert T.; Chan, Paul K.S.; Chen, Zigui

doi:10.1128/spectrum.02410-21

Cited by 22 publications

(26 citation statements)

References 63 publications

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“…Red and blue indicate microorganisms with adverse and protective effects, respectively. Oral microbiota and cardiovascular disease common influencing factors are on the left (7,18,47,48).…”

Section: Bacteremiamentioning

confidence: 99%

“…The oral microbiota is mainly composed of five main phyla (Protebacteria, Firmicutes, Bacteroidetes, Actinobacteria, and Fusobacteriota) (7), of which Proteobacteria; Neisseria, Firmicutes and Streptococcus are the most extensively studied. However, studies have found that the dominant genus in the oral cavity may differ between people in different countries (Chinese population was dominated by Neisseria (7), Canadian population was dominated by Veillonella (47), Qatari population was dominated by Prevotella ( 48)), which may be related to sociodemographics. The gut microbiota generally consists of six main phyla (Firmicutes, Bacteroidetes, Actinobacteria, Pseudomonadota, Fusobacteriota, and Verrucomicrobiota), of which Firmicutes and Bacteroidetes are the dominant phyla (80).…”

Section: Oral-gut Microbiota Transfermentioning

confidence: 99%

“…The oral microbiota is dominated by Streptococcus, belonging to the Firmicutes phylum (36.7%) (4), which produces an abundance of primary and secondary metabolites, and is associated with the occurrence of systemic diseases (5). Studies have shown that age-related variations have little effect on the oral microbiota when compared to other habitats in the bodies of healthy populations (6,7). Furthermore, new evidence suggests that oral microbiota are involved in the preliminary digestion of food in the oral cavity and produce a variety of metabolites (8,9).…”

Section: Introductionmentioning

confidence: 99%

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The oral microbiota and cardiometabolic health: A comprehensive review and emerging insights

Zhu

Liu

et al. 2022

Front. Immunol.

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There is mounting evidence demonstrating that oral dysbiosis causes periodontal disease and promotes the development of cardiovascular disease. The advancement of omics techniques has driven the optimization of oral microbiota species analysis and has provided a deeper understanding of oral pathogenic bacteria. A bi-directional relationship exists between the oral microbiota and the host, and oral-gut microbiota transfer is known to alter the composition of the gut microbiota and may cause local metabolic disorders. Furthermore, cardiovascular health can also be highly affected by oral microbiota functions and metabolites, including short-chain fatty acids (SCFAs), nitric oxide (NO), hydrogen sulfide (H2S), and some lipid metabolites. Studies have found that trimethylamine oxide (TMAO) may have adverse effects on cardiovascular health, whereas SCFAs, NO, and H2S have cardioprotective effects. SCFAs and H2S exert varying oral and cardiovascular effects, however reports on this specific topic remain controversial. Previous evidences are accustomed to summarizing the functions of oral microbiota in the context of periodontitis. The direct relationship between oral microbiota and cardiovascular diseases is insufficient. By systematically summarizing the methods associated with oral microbiota transplantation (OMT), this review facilitates an investigation into the causal links between oral microbiota and cardiovascular disease. The concomitant development of omics, bioinformatics, bacterial culture techniques, and microbiota transplantation techniques is required to gain a deeper understanding of the relationship between oral microbiota and cardiovascular disease occurrence.

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“…Red and blue indicate microorganisms with adverse and protective effects, respectively. Oral microbiota and cardiovascular disease common influencing factors are on the left (7,18,47,48).…”

Section: Bacteremiamentioning

confidence: 99%

Section: Oral-gut Microbiota Transfermentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The oral microbiota and cardiometabolic health: A comprehensive review and emerging insights

Zhu

Liu

et al. 2022

Front. Immunol.

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“… Candida albicans , a common commensal fungus, thrives on a variety of human mucosa types and has been shown to be involved in oral carcinogenesis ( 12 , 13 ). Moreover, interkingdom interactions between bacteria and fungi play an important role not only in healthy people but also in the initiation and progression of disease ( 14 , 15 ). Thus, variations in the bacteriome and mycobiome across major stages of OSCC development require clarification.…”

Section: Introductionmentioning

confidence: 99%

Oral Bacteriome and Mycobiome across Stages of Oral Carcinogenesis

et al. 2022

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“…Два микробных сообщества -бактериальное и грибковое -формируются вследствие воздействия разных факторов [1]. Показано, что у здоровых людей пол и возраст связаны с разнообразием только бактериального компонента микробиоты, но не грибкового.…”

Section: Introductionunclassified

Oral microbiota in patients with oropharyngeal cancer with an emphasis on <i>Candida</i> spp.

Багирова

Петухова

Grigorievskaya

et al. 2022

Opuholi golovy i šei

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Introduction. Interactions between the 2 microbiota components – bacteria and fungi – are of interest as diagnostic and prognostic markers in selection of treatment tactics for oncological patients.Aim. To study microbiota of the oral cavity in patients with primary squamous cell carcinoma of the oropharyngeal area before and after surgical intervention to find biomarkers for rational selection of antifungal drugs.Materials and methods. At the Surgical Department of Head and Neck Tumors of the N. N. Blokhin National Research Center of Oncology, three-component study was performed: investigations of spectrum of Candida spp. isolates, Candida spp. strains’ resistance to antifungals, and oral washes in primary patients before and after surgery. mALDI-Tof microflex LT (Biotyper, Bruker Daltonics, germany) was used for strain identification; Sensititre Yeast ONE, YO10 (Trek Diagnostic System, united kingdom) plates were used for determination of minimal inhibiting concentrations of anti fungals. values of minimal inhibiting concentrations were evaluated based on the European Committee on Antimicrobial Susceptibility Testing (EuCAST) criteria (version 10.0).Results. four-year observation of patients at the surgical department of head and neck tumors of the N. N. Blokhin National Research Center of Oncology showed that the most common species of Candida is C. albicans (73.5 % of cases). Candida spp. resistance to antifungals was detected only for fluconazole (9.3 % of cases) and micafungin (8.0 % of cases), mostly among C. albicans strains. In 31.8 % of primary patients, oral washes prior to surgery showed growth of Candida spp. (probably, tissue colonization). After surgical intervention, Candida spp. growth was detected in 36.4 % of cases, only 1 of which was diagnosed as invasive mycosis. In 54.5 % of cases before and in 72.7 % of cases after surgery, gram-negative rods were detected. After surgical intervention, percentage of enterobacteria and non-fermenters significantly increased: 59.1 % versus 27.3 % (p <0.05) and 63.6 % versus 27.3 % (p <0.02), respectively. prior to surgery, non-fermenting gram-negative bacteria were represented only by P. aeruginosa; after surgery, the spectrum of non-fermenting gram-negative bacteria became wider but percentage of P. aeruginosa remained high: 71.4 %. ERG11 gene was identified only in 1 strain: C. albicans. FKS1 gene also was identified only in 1 strain: C. inconspicua. virulence factor genes were detected in 57.1 % of strains.Conclusion. Surgical intervention is associated with changes in bacterial microbiota but not fugal microbiota. presence of virulence factor genes and resistance genes in Candida spp. strains should be considered a biomarker allowing to differentiate between colonization and candida infection and can be used for rational selection of antifungal drugs in prevention and treatment of invasive candidiasis, especially in the absence of criteria for interpretation of measured minimal inhibiting concentrations of antifungals.

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Determinants and Interactions of Oral Bacterial and Fungal Microbiota in Healthy Chinese Adults

Cited by 22 publications

References 63 publications

The oral microbiota and cardiometabolic health: A comprehensive review and emerging insights

The oral microbiota and cardiometabolic health: A comprehensive review and emerging insights

Oral Bacteriome and Mycobiome across Stages of Oral Carcinogenesis

Oral microbiota in patients with oropharyngeal cancer with an emphasis on <i>Candida</i> spp.

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