Détection précoce du cancer de la prostate chez des apparentés de premier degré au Sénégal

Fall, B.; Ondo, Cyrille Zé; Sarr, Alioune; Ouédraogo, Boukary; Sow, Yaya; Thiam, Amath; Diallo, Yoro; Diao, Bo; Fall, Papa Ahmed; Ndoye, Alain Khassim; Bâ, M.; Diagne, B.A.

doi:10.1016/j.afju.2015.08.002

Cited by 4 publications

(3 citation statements)

References 21 publications

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“…These findings corroborated those reported by Seydou et al in Benin. However, our results differ from those reported by Fall et al in Senegal whose findings were predominantly of score 6 in the Gleason scoring system (ISUP 1) [1,2]. The hypothesis that the digitally guided biopsy remains essential in failure of doing it under the guidance of ultrasound was confirmed.…”

Section: Discussioncontrasting

confidence: 83%

“…Prostate cancer is the most common cancer and the second leading cause of death developed countries [1]. Its incidence has been steadily rising in recent years due partially to the extension of life expectancy of the populations, and the lifestyle change of poor nations adopting more and more western foods rich in calories and lack of physical activities [2].…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of the effectiveness of the prostate biopsy at the Saint Jean De Dieu Hospital of Tanguieta

KF,

et al. 2023

Int J Res Oncol

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Introduction: Prostate cancer is the most common and the second leading cause of cancer death in men in most developed countries. Prostate biopsy remains the gold standard to confirm its diagnosis. Material and Method: This is a prospective study during 6 months, starting from 1st of February to 31st of July 2022. It included all patients who underwent a prostate biopsy that was carried out either following a high tPSA or due to an abnormal digital rectal examination. Results: We performed digitally guided biopsies in 32 patients from whom, average age was 72.43 years and elevation of total PSA was the main reason (71.88%) behind biopsies. The mean total PSA level was 45.69 ng/ml. The tissues removed were essentially prostate tissues, malignant in 28.12% of cases with adenocarcinoma as the only histological type. Conclusion: Prostate biopsy remains the gold standard for the diagnosis of prostate cancer. When indicated in front of an abnormal digital rectal examination, the probabilities of positivity of the samples are high even in the case of digitally guided biopsies in an under-equipped environment.

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Section: Discussioncontrasting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Evaluation of the effectiveness of the prostate biopsy at the Saint Jean De Dieu Hospital of Tanguieta

KF,

et al. 2023

Int J Res Oncol

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“…A study by Fall et al [31] in Senegal involving screening of 119 first-degree relative of patients with prostate cancer found that being black and having a familial risk factor did not appear to increase the incidence of prostate cancer. Rebbeck et al [4] hypothesized that lower rate of prostate cancer in sub-Saharan Africans compared to the higher rates in African Americans and Caribbean could be attributed to the lower genetic and environmental risk associated with sub-Saharan African men.…”

Section: Discussionmentioning

confidence: 99%

A Review of Localized Prostate Cancer: An African Perspective

et al. 2019

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Prostate cancer is the second most common malignancy in males and the sixth leading cause of cancer mortality in men with a relatively higher death rate in men of African descent. In the United States and other parts of Europe, more than 80% of diagnosed prostate cancer is localized, and 80-90% of these men receive some form of treatment. The projected data may not be a direct reflection of the disease in the sub-Saharan region as less than 40% presents with localized disease. Results from prostate cancer screening have shown that most African men in the sub-region have little knowledge of the disease. There are recommended international guidelines for the management of localized prostate cancer, however, a guideline in a local context could be ideal.

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Association of genetic variants with prostate cancer in Africa: a concise review

Acheampong

Adu

Obirikorang

et al. 2021

Egypt J Med Hum Genet

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Background Prostate cancer (PCa) has one of the highest heritability of all major cancers, where the genetic contribution has been documented, and knowledge about the molecular genetics of the disease is increasing. However, the extent and aspects to which genetic variants explain PCa heritability in Africa are limited. Main body In this review, we summarize studies that highlight how identified genetic variants explain differences in PCa incidence and presentation across ethnic groups. We also present the knowledge gaps in PCa genetics in Africa and why Africa represents an untapped potential ground for genetic studies on PCa. A significant number of genome-wide association studies, linkage, and fine-mapping analyses have been conducted globally, and that explains 30–33% of PCa heritability. The African ancestry has a significant mention in PCa incidence and presentation. To date, the candidate gene approach has replicated 23 polymorphisms including dinucleotide and trinucleotide repeats in 16 genes. CYP17-rs743572, CYP3A4-rs2740574, CYP3A5-rs776746, CYP3A43-rs501275, and haplotype blocks, containing these variants, are significantly associated with PCa among some population groups but not others. With the few existing studies, the extent of genetic diversity in Africa suggests that genetic associations of PCa to African ancestry go beyond nucleotide sequence polymorphisms, to a level of environmental adaptation, which may interpret genetic risk profiles. Also, the shreds of evidence suggest that evolutionary history contributes to the high rates of PCa relative to African ancestry, and genetic associations do not always replicate across populations. Conclusion The genetic architecture of PCa in Africa provides important contributions to the global understanding of PCa specifically the African-ancestry hypothesis. There is a need for more prostate cancer consortiums to justify the heritable certainties of PCa among Africans, and emphasis should be placed on the genetic epidemiological model of PCa in Africa.

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Détection précoce du cancer de la prostate chez des apparentés de premier degré au Sénégal

Cited by 4 publications

References 21 publications

Evaluation of the effectiveness of the prostate biopsy at the Saint Jean De Dieu Hospital of Tanguieta

Evaluation of the effectiveness of the prostate biopsy at the Saint Jean De Dieu Hospital of Tanguieta

A Review of Localized Prostate Cancer: An African Perspective

Association of genetic variants with prostate cancer in Africa: a concise review

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