Detection of Vibrio cholerae aDNA in human burials from the fifth cholera pandemic in Argentina (1886–1887 AD)

Ramirez, Darío Alejandro; Saka, Héctor Alex; Nores, Rodrigo

doi:10.1016/j.ijpp.2020.12.004

Cited by 11 publications

(23 citation statements)

References 22 publications

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“…Notably, all ten of these isolates are non-O1 V. cholerae , distantly related to pandemic lineages including the Classical lineage, and are non-toxigenic [1] (, Table S2), as the CE1 sample was predicted to be [2].…”

Section: Data Summarymentioning

confidence: 99%

“…Raw blast n output files, annotated genome assemblies originally collated and used in [1], the VCR query sequence transcribed from Ramirez and colleagues' article [2], and the tree in are provided in a Figshare repository linked to this study: https://dx.doi.org/10.6084/m9.figshare.13636577.…”

Section: Data Summarymentioning

confidence: 99%

“…extracted ancient DNA (aDNA) from sediment taken from the pelvic abdominal cavities of four putative cholera victims from the La Zanja archaeological site in Córdoba, Argentina [2]. Procedures were designed to minimise environmental contamination [2]. They managed to amplify a fragment of the V.…”

Section: Data Summarymentioning

confidence: 99%

“…The authors successfully sequenced the VCR amplicon from one of these samples, and compared this to genome sequences available in GenBank, including partial sequences of two V. cholerae isolates from Argentina [2]. The two genomes which contained a VCR sequence most similar to that found in the fifth pandemic Argentinian sample, here dubbed the CE1 allele, were those of Sa5Y and SA3G, non-O1 V .…”

Section: Data Summarymentioning

confidence: 99%

“…The first of these sequences (allele 1, in 7/10 genomes; ) was identical to that found in Sa5Y and SA3G by Ramirez et al . [2]. The second sequence (allele 2) was found in HE-16 and two Argentinian genomes ().…”

Section: Data Summarymentioning

confidence: 99%

See 4 more Smart Citations

Genomic contextualisation of ancient DNA molecular data from an Argentinian fifth pandemic Vibrio cholerae infection

2021

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Specific lineages of serogroup O1 Vibrio cholerae are notorious for causing cholera pandemics, of which there have been seven since the 1800s. Much is known about the sixth pandemic (1899–1923) and the ongoing seventh pandemic (1961–present), but we know very little about the bacteriology of pandemics 1 to 5. Moreover, although we are learning about the contribution of non-O1 non-pandemic V. cholerae to cholera dynamics during the current pandemic, we know almost nothing about their role in the past. A recent ancient DNA study has presented what may be the first molecular evidence of a V. cholerae infection from the fifth cholera pandemic period (1886–1887 AD) in Argentina. Here, we place the molecular evidence from that study into the genomic context of non-pandemic V. cholerae from Latin America and elsewhere, and show that a gene fragment amplified from ancient DNA is most similar to that of V. cholerae from the Americas, and from Argentina. Our results corroborate and reinforce the findings of the original study, and collectively suggest that even in the 1880s, non-pandemic V. cholerae local to the Americas may have caused sporadic infections in Argentina, just as we know this to have happened during the seventh pandemic in Latin America.

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Section: Data Summarymentioning

confidence: 99%

Section: Data Summarymentioning

confidence: 99%

Section: Data Summarymentioning

confidence: 99%

Section: Data Summarymentioning

confidence: 99%

Section: Data Summarymentioning

confidence: 99%

See 3 more Smart Citations

Genomic contextualisation of ancient DNA molecular data from an Argentinian fifth pandemic Vibrio cholerae infection

2021

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Non-serogroup O1/O139 agglutinable Vibrio cholerae: a phylogenetically and genealogically neglected yet emerging potential pathogen of clinical relevance

2022

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Somatic antigen agglutinable type-1/139 Vibrio cholerae (SAAT-1/139- Vc ) members or O1/O139 V. cholerae have been described by various investigators as pathogenic due to their increasing virulence potential and production of choleragen. Reported cholera outbreak cases around the world have been associated with these choleragenic V. cholerae with high case fatality affecting various human and animals. These virulent Vibrio members have shown genealogical and phylogenetic relationship with the avirulent somatic antigen non-agglutinable strains of 1/139 V. cholerae (SANAS-1/139- Vc ) or O1/O139 non-agglutinating V. cholerae (O1/O139-NAG- Vc ). Reports on implication of O1/O139-NAGVc members in most sporadic cholera/cholera-like cases of diarrhea, production of cholera toxin and transmission via consumption and/or contact with contaminated water/seafood are currently on the rise. Some reported sporadic cases of cholera outbreaks and observed change in nature has also been tracable to these non-agglutinable Vibrio members (O1/O139-NAGVc) yet there is a sustained paucity of research interest on the non-agglutinable V. cholerae members. The emergence of fulminating extraintestinal and systemic vibriosis is another aspect of SANAS-1/139- Vc implication which has received low attention in terms of research driven interest. This review addresses the need to appraise and continually expand research based studies on the somatic antigen non-serogroup agglutinable type-1/139 V. cholerae members which are currently prevalent in studies of water bodies, fruits/vegetables, foods and terrestrial environment. Our opinion is amassed from interest in integrated surveillance studies, management/control of cholera outbreaks as well as diarrhea and other disease-related cases both in the rural, suburban and urban metropolis.

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Death in the Time of Pandemic: A Tuscan Cholera Cemetery at Benabbio (1855)

Fornaciari

2023

Hist Arch

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Cholera was one of the great killers of the 19th century. The pandemic waves that took place between 1823 and 1899 caused hundreds of thousands of deaths in the Mediterranean region and across Europe. However, the excavation of cholera cemeteries is very rare. This article presents the results of excavations at the cholera cemetery of Benabbio, a mountain village near Lucca (northwest Tuscany) in which cholera broke out in the late summer–early autumn of 1855, causing 46 deaths in a population of around 900 inhabitants. The excavation made it possible to detect for the first time the material characteristics of a cholera cemetery. The findings provide a new source for anthropologically reading the reaction of a community facing the mortality crisis, which fluctuated between acceptance of regulations imposed by the authorities and local strategies of resistance.

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Detection of Vibrio cholerae aDNA in human burials from the fifth cholera pandemic in Argentina (1886–1887 AD)

Cited by 11 publications

References 22 publications

Genomic contextualisation of ancient DNA molecular data from an Argentinian fifth pandemic Vibrio cholerae infection

Genomic contextualisation of ancient DNA molecular data from an Argentinian fifth pandemic Vibrio cholerae infection

Non-serogroup O1/O139 agglutinable Vibrio cholerae: a phylogenetically and genealogically neglected yet emerging potential pathogen of clinical relevance

Death in the Time of Pandemic: A Tuscan Cholera Cemetery at Benabbio (1855)

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