“…These two compounds have been already identified in puffer fish and newt from Japan and Solomon Islands (Kudo et al, 2012;Puilingi et al, 2015). 6,6, previously determined (Reverté et al, 2015) to the individual LC-MS/MS and LC-HRMS quantifications. Cross-reactivity factors (in percentage) are 29.9 for 5-deoxyTTX and 11-deoxyTTX, 2.9 for 11-norTTX-6(R)-ol and 11-norTTX-6(S)-ol, <10 -2 for 4,9-anhydroTTX, and <10 -4 for 5,6,11-trideoxyTTX; CRF for 4-epiTTX was assumed to be 1; CRFs for 5,11-dideoxyTTX/6,11-dideoxy and the two new 5,6,11-trideoxyTTX analogues were not available and thus these analogues were not included in the sum of TTXs.…”