Detection of salivary aspiration using radionuclide salivagram SPECT/CT in patients with COPD exacerbation: a preliminary study

Hou, Peng; Deng, Hongxin; Wu, Zhida; Liu, Haiping; Ni, Lei; Zhang, Zheng; Chen, Ping

doi:10.21037/jtd.2016.09.63

Cited by 9 publications

(3 citation statements)

References 23 publications

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“…Dysphagia was examined by the Eating Assessment Tool-10 (EAT-10) [ 27 ] and the 30mL Water Swallow Test (WST) [ 28 ]. In the present study, dysphagia was considered to be present if the results of both tools indicated dysphagia.…”

Section: Methodsmentioning

confidence: 99%

The relationship between dysphagia and frailty among Chinese hospitalized older patients: a serial mediation model through self-perceived oral health and self-reported nutritional status

Yu,

Zhu,

Zhang

et al. 2024

BMC Geriatr

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Background Frailty contributes to adverse outcomes in older adults and places a heavy burden on healthcare resources. Dysphagia is associated with frailty, but the mechanisms by which dysphagia affects frailty in older adults are unclear. This study aimed to investigate a serial mediating effect of self-perceived oral health and self-reported nutritional status in the relationship between dysphagia and frailty among hospitalized older patients in China. Methods This cross-sectional study included 1200 patients aged ≥ 65 years in the Department of Geriatrics, Shaanxi Provincial People’s Hospital. A structured face-to-face interview was used to survey the following questionnaires: General Information Questionnaire, Tilburg Frailty Indicators (TFI), Eating Assessment Tool-10 (EAT-10), 30mL Water Swallow Test (WST), Geriatric Oral Health Assessment Index (GOHAI), and Short-Form Mini-Nutritional Assessment (MNA-SF). A total of 980 participants with complete data were included in the analysis. Statistical analysis was performed using SPSS 26.0 and Amos 28.0 software. Spearman’s correlation analysis was used for correlation analysis of study variables. The results of the multivariate linear regression analysis for frailty were used as covariates in the mediation analysis, and the structural equation model (SEM) was used to analyze the mediating effects among the study variables. Results Dysphagia, self-perceived oral health, self-reported nutritional status, and frailty were significantly correlated (P<0.001). Dysphagia was found to directly affect frailty (β = 0.161, 95%CI = 0.089 to 0.235) and through three significant mediation pathways: (1) the path through self-perceived oral health (β = 0.169, 95%CI = 0.120 to 0.221), accounting for 36.98% of the total effect; (2) the path through self-reported nutritional status (β = 0.050, 95%CI = 0.023 to 0.082), accounting for 10.94% of the total effect; (3) the path through self-perceived oral health and self-reported nutritional status (β = 0.077, 95%CI = 0.058 to 0.102), accounting for 16.85% of the total effect. The total mediation effect was 64.77%. Conclusions This study indicated that dysphagia was significantly associated with frailty. Self-perceived oral health and self-reported nutritional status were serial mediators of this relationship. Improving the oral health and nutritional status of hospitalized older patients may prevent or delay the frailty caused by dysphagia.

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Section: Methodsmentioning

confidence: 99%

The relationship between dysphagia and frailty among Chinese hospitalized older patients: a serial mediation model through self-perceived oral health and self-reported nutritional status

Yu,

Zhu,

Zhang

et al. 2024

BMC Geriatr

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“…Radionuclide techniques have been described and studied in the past, mostly in children, in an attempt to increase the sensitivity of the detection of aspiration. The study is performed by mixing technetium‐99m sulfur colloid with milk or water, followed by delayed imaging up to 24 h 8,9 . Although these tests provide objective diagnostic tools in the diagnosis of aspiration pneumonia, they are not used frequently in clinical practice.…”

Section: Aspiration Pneumoniamentioning

confidence: 99%

Aspiration pneumonia in enteral feeding: A review on risks and prevention

2023

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Enteral feeding plays a critical role in the management of hospitalized patients, especially in intensive care units. In addition to delivering important nutrients, it also maintains the integrity of the gut and microbiota. Enteral feeding is also associated with complications and adverse events, some are related to access placement, metabolic and electrolytes disturbances, and aspiration pneumonia. In tube‐fed patients, aspiration pneumonia has a prevalence ranging from 4% to 95% with a mortality rate of 17%–62%. Our review has not showed any significant difference in the incidence of aspiration pneumonia between gastric and postpyloric feeding and, given the ease of gastric access, we therefore suggest using gastric feeding as an initial strategy for the delivery of nutrition unless postpyloric access is otherwise indicated for other clinical reasons.

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“…14 Oro-pharyngo-esophageal radionuclide scintigraphy (OPERS) is an investigation that is currently done using a radionuclide salivagram to evaluate swallowing and pulmonary aspiration in children and adults. [15][16][17][18] Radionuclide scintigraphy not only detects penetration and aspiration, but also quantifies the amount of food material that enters the chest after swallowing. 19,20 However, there is a paucity of studies reporting on the application of OPERS in the evaluation of aspiration related to dysphagia.…”

Section: Introductionmentioning

confidence: 99%

Oro‐pharyngo‐esophageal radionuclide scintigraphy predicts aspiration pneumonia risk and associated survival in post‐irradiated nasopharyngeal carcinoma patients

Wang

Vlantis

et al. 2021

Laryngoscope Investig Oto

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Objective: To demonstrate that oro-pharyngo-esophageal radionuclide scintigraphy (OPERS) not only detects tracheobronchial aspiration after swallowing, but also quantifies the amount of aspiration and subsequent clearance.Methods: Data collected between 2014 and 2019 were reviewed for aspiration pneumonia at 12 and 24-months after OPERS. The predictive value for aspiration pneumonia on flexible endoscopic evaluation of swallowing (FEES), videofluoroscopic swallowing study (VFSS), and OPERS, and the overall survival of patients with or without aspiration were determined.Results: Thirty-seven patients treated with radiotherapy for nasopharyngeal carcinoma (NPC) were reviewed. The incidence of aspiration detected on FEES, VFSS, and OPERS was 78.4%, 66.7%, and 44.4%, respectively. Using VFSS as a gold standard, the sensitivity and specificity of OPERS for aspiration was 73.7% and 100%.The positive and negative predictive values for aspiration were 100% and 66.7%, respectively, with an overall accuracy of 82.8%. A history of aspiration pneumonia was one factor associated with a higher chance of subsequent aspiration pneumonia within 12 months (odds ratio: 15.5, 95% CI 1.67-145.8, p < .05) and 24 months (odds ratio: 23.8, 95% CI 3.69-152.89, p < .01) of the swallowing assessment. Aspiration detected by OPERS was a significant risk factor for future aspiration pneumonia at 12 and 24 months respectively. Significantly, better survival was associated with an absence of aspiration on OPERS only, but not on FEES or VFSS.

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Detection of salivary aspiration using radionuclide salivagram SPECT/CT in patients with COPD exacerbation: a preliminary study

Cited by 9 publications

References 23 publications

The relationship between dysphagia and frailty among Chinese hospitalized older patients: a serial mediation model through self-perceived oral health and self-reported nutritional status

The relationship between dysphagia and frailty among Chinese hospitalized older patients: a serial mediation model through self-perceived oral health and self-reported nutritional status

Aspiration pneumonia in enteral feeding: A review on risks and prevention

Oro‐pharyngo‐esophageal radionuclide scintigraphy predicts aspiration pneumonia risk and associated survival in post‐irradiated nasopharyngeal carcinoma patients

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