2021
DOI: 10.1002/lio2.704
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Oro‐pharyngo‐esophageal radionuclide scintigraphy predicts aspiration pneumonia risk and associated survival in post‐irradiated nasopharyngeal carcinoma patients

Abstract: Objective: To demonstrate that oro-pharyngo-esophageal radionuclide scintigraphy (OPERS) not only detects tracheobronchial aspiration after swallowing, but also quantifies the amount of aspiration and subsequent clearance.Methods: Data collected between 2014 and 2019 were reviewed for aspiration pneumonia at 12 and 24-months after OPERS. The predictive value for aspiration pneumonia on flexible endoscopic evaluation of swallowing (FEES), videofluoroscopic swallowing study (VFSS), and OPERS, and the overall sur… Show more

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“…[11][12][13] Micro-aspiration of gastric refluxate into the upper and lower airway in gastroesophageal reflux disease (GERD) has been demonstrated using gastroesophageal scintigraphy. 14,15 While aspiration is a long-term sequela of radiotherapy for NPC, commonly due to oropharyngeal dysphagia as shown by previous studies, [16][17][18][19] there are few studies investigating the prevalence of GERD and laryngopharyngeal reflux (LPR) in patients with head and neck cancer after radiotherapy or chemoradiotherapy, and their possible relationship with dysphagia and subsequent pulmonary complications. We aimed to determine the incidence of aspiration pneumonia in patients with NPC, which may be as high as 83.9%, whereas silent aspiration may vary from 42% to 66% in patients with dysphagia after head and neck radiotherapy or chemoradiotherapy.…”
Section: Introductionmentioning
confidence: 99%
“…[11][12][13] Micro-aspiration of gastric refluxate into the upper and lower airway in gastroesophageal reflux disease (GERD) has been demonstrated using gastroesophageal scintigraphy. 14,15 While aspiration is a long-term sequela of radiotherapy for NPC, commonly due to oropharyngeal dysphagia as shown by previous studies, [16][17][18][19] there are few studies investigating the prevalence of GERD and laryngopharyngeal reflux (LPR) in patients with head and neck cancer after radiotherapy or chemoradiotherapy, and their possible relationship with dysphagia and subsequent pulmonary complications. We aimed to determine the incidence of aspiration pneumonia in patients with NPC, which may be as high as 83.9%, whereas silent aspiration may vary from 42% to 66% in patients with dysphagia after head and neck radiotherapy or chemoradiotherapy.…”
Section: Introductionmentioning
confidence: 99%