Detection of recent myocardial ischaemia by molecular imaging of P-selectin with targeted contrast echocardiography

Abstract

Molecular imaging of P-selectin with targeted MCE can identify the presence of recently ischaemic myocardium in the absence of necrosis and after resolution of hypoperfusion and post-ischaemic stunning. This technique can potentially provide a method for risk stratifying patients with acute chest pain.

The Evolution of Ultrasound Technologies; from Anatomic to Physiologic,Histologic, and Molecular Imaging

“…Up-regulation of endothelial adhesion molecule 1 (VCAM-1) and intercellular cell adhesion molecule 1 (ICAM-1) is detected on endothelium of atherosclerotic plaques [26]. Selectins are also upregulated in inflammation [27].…”

The Role of Cardiac Ultrasound in Stem Cell Therapy

“…al. [33] have recently shown that ischemic myocardium can be visualized using contrast echocardiography targeted to P-selectin. It is possible that these techniques may be extended to permit targeted delivery of stem cells.…”

P-Selectin Imaging in Cardiovascular Disease: What You See Is What You Get?

“…However, methodologic problems remain. The agents used were based either on P-selectin-avid antibodies (10,11) or on synthetic analogs of Sialyl Lewis X (SLe X ), the natural ligand of P-selectin (7,8,10). Although the antibody-based agents generally yield good imaging results (9,11), the production of these tracers is expensive and time-consuming.…”

“…Although the antibody-based agents generally yield good imaging results (9,11), the production of these tracers is expensive and time-consuming. The clinical potential of SLe X analogs, on the other hand, is limited by their poor imaging properties (7,8,10).…”

“…Among these are screening of early atherosclerotic disease (12), detection of highrisk atherosclerotic lesions, detection of myocardial ischemia and reperfusion (7,8), and evaluation of therapies for treatment of ischemic injury (10,11). Early detection of disease activity can result in earlier change of lifestyle and start of treatment, thereby reducing the risk of atherosclerotic complications.…”