Detection of Phytoconstituents in Column Fractions of n-Hexane Extract of Goldcrest Honey Exhibiting Anti-Helicobacter pylori Activity

In vitro Assessment of Helicobacter pylori Ureases Inhibition by Honey Fractions

“…Although the combination of a proton pump inhibitor with clarithromycin and amoxicillin is still very effective in the treatment of H. pylori infection and remains a treatment of choice among others, it will be prudent to pre-empt the resistance problem by searching for alternatives as resistance to clarithromycin is increasingly reported (29).…”

Effect of propolis in gastric disorders: inhibition studies on the growth ofHelicobacter pyloriand production of its urease

“…Therefore, the Eregli and Balikesir propolis were distinguished from the other propolis samples. It has been reported that the propolis from both of these areas could be derived from chestnut flora 12 , and chestnut honey and pollen samples have high levels of phenolic substances 13 . The total flavonoid content of the propolis samples ranged from 3.882 to 12.453 mg Q/g sample (Table 1).…”

“…It has been reported that propolis inhibits the growth of many infectious bacteria as well as H. pylori 9 . In recent years, in vivo and in vitro investigations have indicated that polyphenol-rich extracts such as bee products have substantial inhibitory effects 12 . All of the EPEs inhibited H. pylori urease with a wide inhibitory range, that is from 0.260 to 1.525 mg/mL (Table 1).…”

“…The prevalence of antibiotic-resistant H. pylori strains and the side effects associated with the present chemotherapeutic approach driven the search for alternatives to currently available anti-H. pylori drugs, especially regarding safe and effective non-antibiotic agents 9 . Thus, the search for novel H. pylori urease inhibitors in natural products such as plant extracts 10 , honey 11,12 and propolis, with improved stability and low toxicity, is mandatory to improve the quality of life of human with H. pylori infection.…”

Medical honey in professional wound care

“…In addition, it is successfully used in the prevention of radiation-induced mucositis [50]. Researchers have also extracted molecules out of honey, which showed anti-Helicobacter pylori activity [63,64]. Some articles have raised questions about the benefit of honey for certain conditions [65].…”