Medical honey in professional wound care

Biglari, Bahram; Swing, Tyler; Büchler, Axel; Ferbert, Thomas; Simon, Arne; Schmidmaier, Gerhard; Moghaddam, Arash

doi:10.1586/edm.12.66

Cited by 6 publications

(2 citation statements)

References 54 publications

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“…One of the wound management treatments is using ALH in necrotic, secretory, and infected tissues (44). A large part of the literature is focused on using ALH in the adult population (45,46). The effect of ALH in infants was evaluated in a report by Mohr et al on three extravasation cases with different degrees of damage.…”

Section: Active Leptospermum Honeymentioning

confidence: 99%

Management of Extravasation Injury in Infants: A Systematic Review of Clinical Trials

Raisi,

Behzadi Fard,

Behzadifard

et al. 2023

Med Surg Nurs J

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Context: One of the common procedures in the neonatal intensive care unit (NICU) is the insertion of a venous catheter, and one of the most important and serious complications is extravasation, which is a leading cause of death in hospitalized infants. Based on the researcher’s experience in the NICU and the necessity of extravasation injury management in infants, this review study focused on extravasation injury management in infants. Methods: The literature was searched in ProQuest, Scopus, and PubMed databases using the terms “extravasation” OR “vascular leakage” OR “Peripheral Infiltration” AND “Neonatal” OR “Newborn” OR “Infants” OR “NICU.” The search procedure was performed in the title, abstract, and full text of articles published in English from 2000 to 2022. Results: In the initial search, 3414 articles were extracted. After removing the duplicates and searching the titles and abstracts of the articles, 132 related articles were found, and their full texts were studied. Finally, 20 articles entered the final analysis stage. Nine case report studies, five case series studies, three clinical trials, and three retrospective review studies were found. The results showed that various treatment methods are available, including elevating limbs, pain relief, hot and cold compresses, flush-out technique with saline, dressings (hydrocolloid, hydrogel, and hydrocellular foam), medications (2% nitroglycerin ointment and subcutaneous administration of hyaluronidase and phentolamine), and new methods such as amniotic membranes, omega-3-rich fish skin (Kerecis), active leptospermum honey (ALH), PRP, and surgical removal. Conclusions: Despite many medical advances, there is still no specific approach to managing extravasation in infants. The ideal approach to extravasation injuries is still to prevent them initially. The best next step is to minimize the damage using antidotes or hyaluronidase. Using saline to remove the solution and physically minimize damage can be useful. Thus, more studies are needed to address extravasation management in infants.

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Section: Active Leptospermum Honeymentioning

confidence: 99%

Management of Extravasation Injury in Infants: A Systematic Review of Clinical Trials

Raisi,

Behzadi Fard,

Behzadifard

et al. 2023

Med Surg Nurs J

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“…Honey, an ancient wound remedy has gathered renewed interest in its clinical potential for inhibiting a wide range of infectious agents and promoting rapid wound healing [ 131 ]. The availability of medical grade honey with laboratory proven effects at the cellular and molecular level against certain microorganisms is not uncommon [ 131 , 132 , 133 , 134 ]. Mechanisms of bacterial inhibition within biofilm formation attributed to honey is a particular focus due to the increasing multidrug resistance of biofilm-associated organisms.…”

Section: Promising Novel Therapies For Prevention and Treatment Ofmentioning

confidence: 99%

Targeting the Bacterial Protective Armour; Challenges and Novel Strategies in the Treatment of Microbial Biofilm

et al. 2018

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Infectious disease caused by pathogenic bacteria continues to be the primary challenge to humanity. Antimicrobial resistance and microbial biofilm formation in part, lead to treatment failures. The formation of biofilms by nosocomial pathogens such as Staphylococcus aureus (S. aureus), Pseudomonas aeruginosa (P. aeruginosa), and Klebsiella pneumoniae (K. pneumoniae) on medical devices and on the surfaces of infected sites bring additional hurdles to existing therapies. In this review, we discuss the challenges encountered by conventional treatment strategies in the clinic. We also provide updates on current on-going research related to the development of novel anti-biofilm technologies. We intend for this review to provide understanding to readers on the current problem in health-care settings and propose new ideas for new intervention strategies to reduce the burden related to microbial infections.

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