Detection of hydrogen sulphide based on a novel G-quadruplex selective fluorescent probe

Hydrogen Sulfide: An Emerging Precision Strategy for Gas Therapy

“…ity and response time of detection, fluorescent probes with superior advantages for monitoring H 2 S in real time have been widely investigated. [337][338][339][340][341][342][343][344][345][346][347][348][349][350] However, the applications for in vivo H 2 S detection are severely limited because of the low tissue penetration and spatial resolution, as well as the poor photostability. Thus, other advanced imaging techniques for superior H 2 S detection have been developed, such as NIR-I/II, PA, MR, and PET imaging, allowing for early detection and diagnosis of diseases, realtime observation of biological processes during targeted delivery, cellular uptake, and biodistribution of therapeutics in a detailed manner (Table 3).…”

3-Hydroxyflavone derivatives: promising scaffolds for fluorescent imaging in cells

“…101 Small molecules bind to DNA by four modes referred to as intercalative binding within the base pairs, groove binding through van der Waal's interaction, electrostatic binding at the negatively charged DNA phosphate backbone, and bases binding through p-p stacking. 102,103 At present, it has been reported that some 3HF derivatives (such as 3HF, setin, and quercetin) can bind to ss-DNA, ds-DNA, triplex DNA and Gquadruplex, thereby modulating their uorescence emission and ESIPT process. [103][104][105][106][107][108] Therefore, summarizing the effects of DNA binding on the uorescence emission of 3HF derivatives has guiding signicance for designing novel DNA based sensors and probes.…”

“…102,103 At present, it has been reported that some 3HF derivatives (such as 3HF, setin, and quercetin) can bind to ss-DNA, ds-DNA, triplex DNA and Gquadruplex, thereby modulating their uorescence emission and ESIPT process. [103][104][105][106][107][108] Therefore, summarizing the effects of DNA binding on the uorescence emission of 3HF derivatives has guiding signicance for designing novel DNA based sensors and probes.…”

“…10a ). 103 A variety of G-quadruplexes (TBA is the only exception) can selectively amplify the fluorescent signals of compound 6, whereas the presence of ssDNA (G4TTA-C) and ctDNA have moderate effects on the emission. 103 Through molecular docking simulations, we found that compound 6 forms strong interactions with parallel G-quadruplex (such as c-MYC) through multiple π–π stacks and one hydrogen bond, and only forms weak interactions with ssDNA and TBA through hydrogen bonds ( Fig.…”