3-Hydroxyflavone derivatives: promising scaffolds for fluorescent imaging in cells

Abstract

Considering that biological macromolecules offer hydrophobic microenvironment, 3HF is a promising scaffold for the development of fluorescent imaging in cells.

Lactam-fused tropolones: a new tunable, environmentally sensitive fluorophore class

“…Moving forward, we believe that one close parallel to this newly described class of fluorophores are the chromones, such as 3-hydroxyflavone, which are widely used throughout the scientific community (Scheme 7). 27 Structurally, tropolones and hydroxypyrones have common polarizability to their tropylium and pyrylium forms, and each undergo rapid proton transfer, 28 characteristics that can readily lead to excited state intramolecular proton transfer (ESIPT). 29 This could help explain the exceptionally large stoke shift of many of the compounds studied.…”

Revisiting the Pharmacological Potential of 3‐Hydroxyflavone Derivatives (3HF) in Transdermal Drug Delivery by Electrospun Cellulose Acetate Nanofiber

“…Flavanols have the best electron‐conjugated skeleton in the flavonoid family, exhibiting several resonance structures, and through their structural features, they can interact with the various receptors in the biological system. Their high electron conjugation gives them fluorescent properties, allowing them to be employed as therapeutic imaging agents [8,9] …”

“…Their high electron conjugation gives them fluorescent properties, allowing them to be employed as therapeutic imaging agents. [8,9] Several flavonols have been reported to own anti-inflammatory activity with minimal side effects. Luteolin and apigenin are known anti-inflammatory agents in treating inflammatory diseases through various mechanisms.…”

Electronegativity effect on the ESIPT process of 4′‐N,N‐dimethylamino‐3‐hydroxyflavone (DMA3HF) and its derivatives

“…18,19 3-hydroxyflavone (3HF) is a typical fluorescent chromophore with ESIPT property. 20 4 0 -N,N-dimethylamino-3-hydroxyflavone (DMA3HF) belongs to 3-HF family and has excellent photophysical properties and antioxidant activity, which make it a hot research topic. [21][22][23] The fluorescence properties of DMA3HF have been controlled by appropriate external environmental conditions, which has significant contribution to physical sensing.…”