Detection of human papillomavirus in large cell neuroendocrine carcinoma of the uterine cervix: a study of 12 cases

Abstract

Integration of high risk HPV, in particular type 16 and to a lesser extent type 18, is associated with this uncommon variant of cervical carcinoma.

HPV genotyping in neuroendocrine carcinoma of the uterine cervix in northern Thailand

“…The reported incidence of HPV infection in cervical NECA has varied in previous studies [3][4][5][6][7][8][9][10][11][12][13][14][15]. Except for 1 study with completely negative results [4], others have demonstrated the presence of HPV DNA in most cases, ranging from 53% to 100% [3,[5][6][7][8][9][10][11][12][13][14][15].…”

“…Knowledge of the distribution of HPV genotype in NECA would enable us to estimate the potential benefit of currently available HPV vaccines, which are protective against HPV16 and HPV18 infections. Previous studies of HPV genotyping in cervical NECA have reported the presence of HPV16 and/or HPV18 infection in 63%-100% of cases, with the prevalence of HPV18 infection ranging from 12.5% to 100% [3][4][5][6][7][8][9][10][11][12][13][14][15]. However, these findings were based on only a limited number of NECA cases in each study and should not be used as a reference for predicting the benefit of the prophylactic vaccine.…”

“…Although the previously reported prevalence of HPV18 infection in cervical NECA varies, the number of cases in each study was small (ranging from 4 to 26) [3][4][5][6][7][8][9][10][11][12][13][14][15]. Cumulative data from the previous reports of HPV genotyping in cervical NECA indicate that HPV18 is the predominant subtype with a prevalence of 69.1% (105/152 cases with single or multiple infections), whereas HPV16 is the second most common subtype, accounting for 28.9% (44/152 cases) [3][4][5][6][7][8][9][10][11][12][13][14][15]. HPV genotypes other than HPV16 and HPV18, including HPV3, HPV45, HPV68, and HPV90, have been found to be uncommon (1 case of each type) [7,13].…”

Human Papillomavirus-16 Associated Adenocarcinoma NOS of Base of Tongue

“…This situation resembles the role played by HPV in the carcinogenesis of uterine cervix where HPV is found not only in squamous cell carcinoma [30], but also in adenocarcinomas [31], and neuroendocrine carcinomas [32,33].…”

The role of human papillomaviruses in cancer progression

“…This becomes even more apparent at the puberty time and the onset of sexual activity. [60] The initial infection of the cell and the relation of this to the disease outcome are not well understood. Generally HPV infection causes cell destruction as well as cell transformation and tumour development.…”