HPV genotyping in neuroendocrine carcinoma of the uterine cervix in northern Thailand

Siriaunkgul, Sumalee; Utaipat, Utaiwan; Settakorn, Jongkolnee; Sukpan, Kornkanok; Srisomboon, Jatupol; Khunamornpong, Surapan

doi:10.1016/j.ijgo.2011.06.010

Cited by 25 publications

(19 citation statements)

References 22 publications

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“…The high prevalence of HR-HPV infection among Thai women with ICC also has been consistently reported across the regions ranging from 77% to 97% (Tungsinmunkong et al, 2006;Siriaunkgul et al, 2008;Siriaunkgul et al, 2011;Chinchai et al, 2012;Natphopsuk et al, 2013;Siriaunkgul et al, 2013;Aromseree et al, 2014). In addition, more than 60% of ICC was HPV 16 and/or 18-related supporting that the majority of ICC in all regions is associated with HPV16 and/or 18.…”

Section: Invasive Cervical Cancer (Icc)mentioning

confidence: 81%

“…In addition, more than 60% of ICC was HPV 16 and/or 18-related supporting that the majority of ICC in all regions is associated with HPV16 and/or 18. Multiple HPV infection in Thai women varied widely from approximately 6% to 20% depending on histologic subtypes of ICC (Table 4) (Siriaunkgul et al, 2008;Siriaunkgul et al, 2011;Chinchai et al, 2012;Natphopsuk et al, 2013;Siriaunkgul et al, 2013).…”

Section: Invasive Cervical Cancer (Icc)mentioning

confidence: 99%

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Human Papillomavirus Genotype Distribution among Thai Women with High-Grade Cervical Intraepithelial Lesions and Invasive Cervical Cancer: a Literature Review

Kietpeerakool

Kleebkaow²,

Srisomboon³

2015

Asian Pacific Journal of Cancer Prevention

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Asian Pac J Cancer Prev, 16 (13), [5153][5154][5155][5156][5157][5158] IntroductionMore than 90% of worldwide estimated human papillomavirus (HPV)-related cancer mortalities are secondary to invasive cervical cancer (Cutts et al., 2007). There are sufficient evidences to conclude that cervical cancer are virtually caused by complicated infection with high-risk (HR) or carcinogenic types of HPV. According to the recent classification proposed by the International Agency for Research on Cancer, twelve HR-HPV genotypes including type 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, and 59 are classified as one of 114 agents that are carcinogenic to human, or the so-called "group A" (IARC, 2006).As a substantial geographical variation in the HPV genotype distribution has been observed (Li et al., 2011), data regarding HPV type-specific prevalence in each country are therefore mandatory for providing baseline information to predict how the genotype-specific HPV vaccination and HPV-based screening will influence cervical cancer prevention. Accordingly, we evaluated the

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Section: Invasive Cervical Cancer (Icc)mentioning

confidence: 81%

Section: Invasive Cervical Cancer (Icc)mentioning

confidence: 99%

Human Papillomavirus Genotype Distribution among Thai Women with High-Grade Cervical Intraepithelial Lesions and Invasive Cervical Cancer: a Literature Review

Kietpeerakool

Kleebkaow²,

Srisomboon³

2015

Asian Pacific Journal of Cancer Prevention

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“…The cases of cervical NECA diagnosed between 2003-2009, which were known to be HPV18-positive in a previous PCR study (Siriaunkgul et al, 2011), were retrieved. The diagnosis of NECA was based on the standard morphologic criteria by a consensus agreement of 4 pathologists (S.S., S.K., J.S, and K.S.…”

Section: Methodsmentioning

confidence: 99%

“…DNA extraction from paraffin-embedded tissue was performed based on previously described methods (Siriaunkgul et al, 2011). Quantiative PCR (qPCR) for HPV18 quantitation was carried out using TaqMan chemistry on the ABI PRISM 7500 Sequence Detection System instrument.…”

Section: Methodsmentioning

confidence: 99%

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Prognostic Value of HPV18 DNA Viral Load in Patients with Early-Stage Neuroendocrine Carcinoma of the Uterine Cervix

Siriaunkgul

Utaipat²,

Suwiwat³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Objectives: To evaluate the clinicopathologic correlation and prognostic value of HPV18 DNA viral load in patients with early-stage cervical neuroendocrine carcinoma (NECA). Methods: Formalin-fixed, paraffinembedded tissue of cervical NECA patients with known HPV18 infection and clinicopathologic data including follow-up results were collected. The HPV18 DNA load was assessed with quantitative PCR targeting the HPV18 E6E7 region. Results: Twenty-one patients with early-stage (IB-IIA) cervical NECA were identified. HPV18 DNA viral load ranged from 0.83 to 55,174 copies/cell (median 5.90). Disease progression, observed in 10 cases (48%), was not significantly associated with any clinicopathologic variables. However, the group of patients with progressive disease tended to have a higher rate of pelvic lymph node metastasis (50% versus 9%, p=0.063) and a lower median value of HPV18 DNA viral load (4.37 versus 8.17 copies/cell, p=0.198) compared to the non-recurrent group. When stratified by a cut-off viral load value of 5.00 copies/cell, the group of patients with viral load ≤5.00 copies/cell had a significantly shorter disease-free survival than the group with viral load >5.00 copies/cell (p=0.028). The group with a lower viral load also tended to have a higher rate of disease progression (75% versus 31%, p=0.080). No significant difference in the other clinicopathologic variables between the lower and higher viral load groups was identified. Conclusion: HPV18 DNA viral load may have a prognostic value in patients with early-stage NECA of the cervix. A low viral load may be predictive of shortened disease-free survival in these patients.

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Small Cell Neuroendocrine Carcinoma of the Cervix

Foley

Bradford

Carmen

2014

Uncommon Gynecologic Cancers

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HPV genotyping in neuroendocrine carcinoma of the uterine cervix in northern Thailand

Abstract: HPV18 infection was predominant in cervical NECA. Variations in HPV genotype may be related to the clinicopathologic features and pathogenetic pathways of NECA. Vaccination against HPV16 and HPV18 might provide protection against cervical NECA in almost 90% of cases.

Cited by 25 publications

References 22 publications

Human Papillomavirus Genotype Distribution among Thai Women with High-Grade Cervical Intraepithelial Lesions and Invasive Cervical Cancer: a Literature Review

Human Papillomavirus Genotype Distribution among Thai Women with High-Grade Cervical Intraepithelial Lesions and Invasive Cervical Cancer: a Literature Review

Prognostic Value of HPV18 DNA Viral Load in Patients with Early-Stage Neuroendocrine Carcinoma of the Uterine Cervix

Small Cell Neuroendocrine Carcinoma of the Cervix

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