2007
DOI: 10.1111/j.1469-0691.2007.01827.x
|View full text |Cite
|
Sign up to set email alerts
|

Detection of human bocavirus in children with Kawasaki disease

Abstract: Human bocavirus (HboV) is an emerging virus that has been implicated as a cause of acute upper and lower respiratory tract infection in children. As no serological assay is available, PCR was used to screen nasopharyngeal, serum or stool samples from 16 patients with Kawasaki disease for HBoV nucleic acid. HBoV was identified by PCR in five (31.2%) patients, suggesting that this emerging virus may also play a pathogenic role in some cases of Kawasaki disease.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
27
0
1

Year Published

2009
2009
2024
2024

Publication Types

Select...
7
2

Relationship

0
9

Authors

Journals

citations
Cited by 38 publications
(31 citation statements)
references
References 12 publications
0
27
0
1
Order By: Relevance
“…Based on the clinical, epidemiological, and immunological features of KD, the pathogenesis of KD could be a hyperimmune reaction in genetically susceptible children to a ubiquitous virus. Catalano-Pons et al 2 have also identified HBoV by PCR in five (31.2%) patients with KD, suggesting that this emerging virus may also play a pathogenic role in some cases of KD. Additional studies are required to understand the physiopathology of this new virus.…”
Section: Discussionmentioning
confidence: 93%
See 1 more Smart Citation
“…Based on the clinical, epidemiological, and immunological features of KD, the pathogenesis of KD could be a hyperimmune reaction in genetically susceptible children to a ubiquitous virus. Catalano-Pons et al 2 have also identified HBoV by PCR in five (31.2%) patients with KD, suggesting that this emerging virus may also play a pathogenic role in some cases of KD. Additional studies are required to understand the physiopathology of this new virus.…”
Section: Discussionmentioning
confidence: 93%
“…1 KD is a multisystemic vasculitis of small to medium size vessels. 1,2 The natural history of KD reveals that coronary artery aneurysms occur as a sequel of the vasculitis in 20% to 25% of untreated children. Although the cause of KD remains unknown, clinical trials have established effective therapies, despite the absence of a proven cause.…”
Section: Introductionmentioning
confidence: 99%
“…A wide variety of microbiological and molecular methods have been employed in order to isolate pathogens from body fluidsand/or detect agent -specific nucleic acids retrospectively, however with,limited results (Kawasaki et al, 1974;Melish et al, 1976;Rowley et al, 1994). Although there have been numerous reports suggesting the involvement of infectious agents such as Parvovirus B19, Bocavirus, Cytomegalovirus or other viruses, Propionibacterium acnes, Rickettciae, and Yersiniae, none of these agents have been seen consistently isolated in children with KD (Catalano-Pons et al, 2007;Esper et al, 2005;Wang et al, 2004). Among the 34 cases of children hospitalized with KD in our study, some were examined for a variety of infectious agents as presented in table 1.…”
Section: Aetiologymentioning
confidence: 99%
“…Destaca el porcentaje de co-infección con otros virus, 34,6 a 72% en diversas series, lo que ha llevado a cuestionar su rol como patógeno respiratorio 5,8,18,20 . Otros estudios muestran que HBoV ha sido identificado en 31% (5/16) de pacientes con enfermedad de Kawasaki sugiriendo que este virus podría tener un rol patogénico en algunos casos de esta patología 33 . Se han postulado mecanismos inmunopatológicos en la enfermedad de Kawasaki con participación de otros agentes virales como virus Epstein-Barr, ADV y citomegalovirus.…”
Section: Estudios De Caracterización Clínicaunclassified