Kawasaki disease and human bocavirus—potential association?

Santos, R A d; Nogueira, Célia; Granja, Sofía; Baptista, Joana; Ribeiro, M.L.; Rocha, Meqa

doi:10.1016/j.jmii.2011.01.016

Cited by 8 publications

(5 citation statements)

References 14 publications

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“…In particular, monthly detections of human bocavirus and enterovirus showed significant indirect correlations with KD occurrence. Several studies have shown that human bocavirus may play a pathogenic role in the development of KD using direct specimen tests from KD patients 10)15). The association with enterovirus such as coxsackie virus and KD occurrence also has been suggested from several case series 11)16)…”

Section: Discussionmentioning

confidence: 97%

Evaluation of the Temporal Association between Kawasaki Disease and Viral Infections in South Korea

et al. 2014

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Background and ObjectivesThis study is aimed at elucidating potential temporal associations between the occurrence of Kawasaki disease (KD) and various viral infections.Subjects and MethodsWe obtained monthly patterns of KD from the seventh nationwide survey and viral detection data from the Korea Centers for Disease Control and Prevention from 2009 to 2011 and evaluated temporal correlations between them for each month. The respiratory viruses detected using a multiplex real-time-polymerase chain reaction kit were influenza virus (A/H1N1, A/H3N2, A/H5N1, and B), adenovirus, parainfluenza virus (type 1, 2, 3), respiratory syncytial virus (type A, B), human rhinovirus, human coronavirus (OC43/229E, NL63), human bocavirus, and enterovirus.ResultsWe obtained data from a total of 13031 patients who were treated for acute KD from 87 hospitals with pediatric residence programs. During this survey, KD showed highest overall incidence in summer and winter seasons and lowest incidence in February and October. We received viral detection data for a total of 14267 patients. Viral detection was highest during winter and spring seasons. The most commonly detected virus was human rhinovirus (32.6%), followed by influenza virus (26.8%). The monthly incidence of KD showed significant correlation with the monthly overall viral detection (p=0.022, r=0.382). In particular, human bocavirus and enterovirus have significant correlations with monthly patterns of KD occurrence (p=0.032 and p=0.007, respectively) and influenza virus correlated with KD occurrence with borderline significance (p=0.063).ConclusionThe temporal association between monthly occurrence of KD and viral detection suggests the etiologic importance of precedent infection in the development of KD.

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Section: Discussionmentioning

confidence: 97%

Evaluation of the Temporal Association between Kawasaki Disease and Viral Infections in South Korea

et al. 2014

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“… 40 In particular for bocavirus, its nucleic acid was found in the nasopharyngeal, serum and stool samples from 5/16 (31.2%) patients with KD by reverse transcriptase-polymerase chain reaction (RT-PCR). 41 A prospective study by Bajolle et al revealed that bocavirus was present in the serum of 3/32 (9%) and in the nasopharyngeal aspirate of 7/32 (21.8%) patients with KD, who probably had a previous bocavirus infection heralding KD. 42 Metagenomic sequencing and PCR detected torque teno virus 7 in only 2/11 (18%) patients with KD prospectively evaluated for one year, 43 while the most recent reports have highlighted the association of KD with Epstein-Barr virus, 44 parvovirus B19 45 and influenza virus.…”

Section: A Viral Infection To Switch On Kawasaki Diseasementioning

confidence: 99%

- Kawasaki Disease as the Immune-Mediated Echo of a Viral Infection

Rigante

2020

Mediterr J Hematol Infect Dis

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Although etiology of Kawasaki disease remains elusive, the available evidence indicates that the primum movens might be a dysregulation of immune responses to various microbes, i.e. a kind of immune-mediated response induced by a viral infection. Even if several data might suggest that Kawasaki disease is an infection-related clinical syndrome, which can develop only in children with a predisposing genetic background, our knowledge on both the infectious agents involved and the genetic characteristics of children prone to the disease remains poor.

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“…This virus was first identified in nasopharyngeal, serum or stool samples, and was thus suggested to play a pathogenic role in some cases of Kawasaki disease (Catalano-Pons et al, 2007). Late, this work was verified by the results from another group showing that HboV can indeed be detected in nasopharyngeal secretions of KD patients, demonstrating a coincidental or possible etiological association between HboV infection and KD pathogenesis (Santos et al, 2011). Furthermore, a significant correlation between HboV infection and KD incidence was identified based on epidemiological data (Kim et al, 2014;Lim et al, 2021), whereas some investigators have proposed that there is little correlation between HboV infection and KD based on the serological test (Lehmann et al, 2009).…”

Section: Bocavirusmentioning

confidence: 75%

Emerging evidence of microbial infection in causing systematic immune vasculitis in Kawasaki disease

Wang,

Zhu,

et al. 2023

Front. Microbiol.

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Kawasaki disease (KD) is a systematic vasculitis that is often complicated by coronary artery lesions and is a leading cause of acquired heart disease in developed countries. Previous studies have suggested that genetic susceptibility, together with an inducing infectious agent, could be involved in KD pathogenesis; however, the precise causative agent of this disease remains unknown. Moreover, there are still debates concerning whether KD is an infectious disease or an autoimmune disease, although many studies have begun to show that various pathogens functioning as critical inducers could activate different kinds of immune cells, consequently leading to the dysfunction of endothelial cells and systematic vasculitis. Here in this review, we attempt to summarize all the available evidence concerning pathogen infections associated with KD pathogenesis. We also discuss the related mechanisms, present a future perspective, and identify the open questions that remain to be investigated, thereby providing a comprehensive description of pathogen infections and their correlations with the host immune system in leading to KD.

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Kawasaki disease and human bocavirus—potential association?

Cited by 8 publications

References 14 publications

Evaluation of the Temporal Association between Kawasaki Disease and Viral Infections in South Korea

Evaluation of the Temporal Association between Kawasaki Disease and Viral Infections in South Korea

- Kawasaki Disease as the Immune-Mediated Echo of a Viral Infection

Emerging evidence of microbial infection in causing systematic immune vasculitis in Kawasaki disease

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