Detection of Fluorophosphonate Chemical Warfare Agents by Catalytic Hydrolysis with a Porous Silicon Interferometer

Organophosphorous Compounds-Toxicity and Detection Approach

“…This method is sensitive and reliable but can not carried out in field, it is expensive and time consuming too. In addition to this, variety of approaches have been investigated for sensors, including enzymatic assays (Russell et al, 2003), molecular imprinting coupled with luminescence (Jenkins et al, 1997;Rudzinski et al, 2002), colorimetric methods (Wallace et al, 2005), surface acoustic waves (Nieuwenhuizen & Harteveld, 1997), fluorescent organic molecules (Yamaguchi et al, 2005;Zhang & Swager, 2003), interferometry (Sohn et al, 2000) and enzyme biosensors based on inhibition of cholinesterase activity (Evtugyn et al, 1996;Trojanowicz, 2002).…”

Chromogenic detection of nerve agent mimics

“…Spectral data were in agreement with those described in the literature. 8 Then, 2-(2-nitrophenyl)ethanol (3.30 g, 19.7 mmol), formaldehyde (37%) (4.83 mL, 32.3 mmol), abs. ethanol (200 ml) and Pd/C (10%) (480 mg) were placed under an H 2 atmosphere until the uptake of hydrogen ceased.…”

“…An alternative to these classical methods that has been gaining interest in recent years is the development of fluorogenic or chromogenic chemosensors or reagents. 2 Reported paradigms involve PET-based fluorescent probes, 3 colorimetric probes with oximate-containing derivatives, 4 molecular imprinting polymers, 5 nanoparticles, 6 carbon nanotubes, 7 porous silicon 8 or displacement-like assays. 9 Most of these reported protocols rely on fluorescence changes and as far as we know chromogenic systems for nerve agent detection in aqueous solution or as vapour are rare.…”

Imprinted Polymer Inclusion Membrane Based Potentiometric Sensor for Determination and Quantification of Diethyl Chlorophosphate in Natural Waters

“…There have been many innovations for the detection of this species including colorimetric detection methods [7,8] surface acoustic wave devices [9,10], enzymatic assays [11], interferometry [12] and fluorescent sensors [13][14][15]. However, all are plagued by at least one limitation or other such as slow response, lack of selectivity, poor sensitivity, operational complexities or non-portability.…”