Chromogenic detection of nerve agent mimics

Abstract

A new chromogenic protocol for the selective detection of nerve agent mimics is reported.

Colorimetric Stimuli-Responsive Hydrogel Polymers for the Detection of Nerve Agent Surrogates

“…The mode of action for these nerve agents is the inhibition of the enzyme acetylcholinesterase, which results in continuous overstimulation of muscles that can ultimately result in death. The need for proper protection against these threats has led to the development of a variety of detection schemes for CWAs over the past few decades, 1,2 including chromatographic, [3][4][5][6] spectroscopic, 7-10 electrochemical, 11-15 fluorogenic, [16][17][18][19][20][21][22][23][24][25] and colorimetric [26][27][28][29] approaches. Fewer reports can be found for polymer-based detection schemes.…”

Detection of 2-(Dialkylamino)ethanethiols and v-Series Nerve Agents in Water and Aqueous Solutions Using Folin-Ciocalteu Reagent

“…However, in principle this method does not enable mutual distinguishing Faculty of Environmental Technology, Institute of Chemical Technology, Technická 5, 166 28 Prague, Czech Republic lukas.matejovsky@vscht.cz +420 22044 5069 of organophosphorus nerve agent groups. This is possible only after suitable sample pre-treatment using special procedures based on the different efficiencies of oxime reactivators of AChE [4], or also using other physical, physicochemical and chemical methods with various levels of instrumentation and sensitivity [5][6][7]. The most frequently used methods include chemical methods based on their nucleophilic substitution with alcoholate or hydroxide ions yielding 2-(dialkylamino)ethanethiols, the determination being usually based on their strong reducing effects accompanied by colour changes.…”

Thiophene-Fused Tropones as Chemical Warfare Agent-Responsive Building Blocks

“…8,9 Colorimetric sensors are attractive as a result of their excellent operational simplicity, portability, and ability to integrate functionality that reacts with CWAs. Colorimetric schemes have been reported with reactive aldehydes, 10 alcohols, [11][12][13][14][15][16] oximes, [17][18][19][20] and amines. 21 Although many solution-based colorimetric detection schemes have been reported, there are far fewer examples with colorimetric responses in thin films, which is necessary for the real-time detection of organophosphates.…”

“…Sarin, Soman, Tabun). 12,13,16,28 These organophosphorus CWA simulants are known to degrade to acidic products over time, 14 and to prevent interference (false positives) from strong acid, we syringefiltered a 1M DCP solution in dichloromethane through a pad of dry potassium carbonate before each sensing experiment. To evaluate the response of alcohol RM1a to DCP, we exposed a 5 µM solution of RM1a in dry dichloromethane to DCP at a concentration of 40 ppm.…”