Detection of Florfenicol Resistance Genes in
            <i>Escherichia coli</i>
            Isolated from Sick Chickens

Keyes, Kathleen; Hudson, Charlene R.; Maurer, John J.; Thayer, Stephan G.; White, David G.; Lee, Margie D.

doi:10.1128/aac.44.2.421-424.2000

Cited by 132 publications

(103 citation statements)

References 17 publications

(16 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the light of evidence of horizontal transfer of the DT104 antibiotic resistance gene cluster to other Typhimurium phage types or other S. enterica serovars [18], these methods appear to be no longer suitable for the specific detection of multidrug-resistant S. enterica Typhimurium DT104. Let us also mention the recently described occurrence of florfenicol resistance encoded by the floR gene on conjugative plasmids or on the chromosome of Escherichia coli isolated from cattle and poultry [17,25,53].…”

Section: Molecular Identification and Detection Methodsmentioning

confidence: 99%

Molecular characterization, spread and evolution of multidrug resistance in Salmonella enterica Typhimurium DT104

2001

View full text Add to dashboard Cite

-Multidrug-resistant Salmonella enterica serovar Typhimurium phage type DT104 has emerged during the last decade as a global health problem because of its involvement in diseases in animals and humans. Multidrug-resistant DT104 strains are mostly resistant to ampicillin, chloramphenicol, streptomycin, sulfonamides and tetracyclines (ACSSuT resistance type). The genes coding for such resistances are clustered on the chromosome. This paper reviews new developments in the characterization of S. enterica Typhimurium DT104, its chromosomal antibiotic resistance genes and their spread among other S. enterica Typhimurium phage types and other S. enterica serovars, the development of specific detection methods, virulence characteristics, and the evolution of multidrugresistance with regard to the emergence of quinolone resistance.Salmonella Typhimurium DT104 / multidrug resistance / Salmonella genomic island I Résumé -Caractérisation moléculaire, diffusion et évolution de la résistance multiple aux antibiotiques chez Salmonella enterica Typhimurium DT104. Le lysotype DT104 de Salmonella enterica Typhimurium présentant une résistance multiple aux antibiotiques a émergé durant la dernière décennie comme un problème mondial de santé publique qui touche à la fois humains et animaux. Les souches du lysotype DT104 sont en général résistantes à l'ampicilline, au chloramphénicol, à la streptomycine, aux sulphamides et aux tétracyclines (profil de résistance ACSSuT). Les gènes codant pour ces résistances sont groupés sur le chromosome. Cet article présente une revue des derniers dévelop-pements dans la caractérisation de S. enterica Typhimurium DT104, ses gènes chromosomiques de résis-tance et leur diffusion chez d'autres lysotypes de S. enterica Typhimurium et d'autres serotypes de S. enterica, le développement de méthodes spécifiques de détection, les caractéristiques de virulence, et l'évolution de la résistance multiple au regard de l'émergence de la résistance aux quinolones.Salmonella Typhimurium DT104 / résistance multiple / îlot génomique I Vet. Res. 32 (2001) [301][302][303][304][305][306][307][308][309][310] 301

show abstract

Section: Molecular Identification and Detection Methodsmentioning

confidence: 99%

Molecular characterization, spread and evolution of multidrug resistance in Salmonella enterica Typhimurium DT104

2001

View full text Add to dashboard Cite

show abstract

“…Finally, we detected the floR gene in only one isolate. Other studies have reported the presence of floR in a large number of E. coli strains from chickens and cattle (7,16,35).…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Resistance Genes in Enterotoxigenic Escherichia coli O149:K91 Isolates Obtained over a 23-Year Period from Pigs

Maynard

Fairbrother

Békal

et al. 2003

Antimicrob Agents Chemother

254

148

View full text Add to dashboard Cite

A total of 112 Escherichia coli O149:K91 strains isolated from pigs with diarrhea in Quebec, Canada, between 1978 and 2000 were characterized for their genotypic antimicrobial resistance profiles. Tests for resistance to 10 antimicrobial agents were conducted. Resistance to tetracycline and sulfonamides was found to be the most frequent, but resistance to cefotaxime and ceftiofur was absent. An increase in the number of isolates resistant to at least three antimicrobials was observed over time. The distribution of 28 resistance genes covering six antimicrobial families (beta-lactams, aminoglycosides, phenicols, tetracycline, trimethoprim, and sulfonamides) was assessed by colony hybridization. Significant differences in the distributions of tetracycline [tet(A), tet(B), tet(C)], trimethoprim (dhfrI, dhfrV, dhfrXIII), and sulfonamide (sulI, sulII) resistance genes were observed during the study period (

show abstract

“…Efflux systems which confer either only chloramphenicol resistance or combined resistance to chloramphenicol and florfenicol have also been described [2,3,8,17,18,32,77]. Permeability barriers and multidrug transporters only play a role in certain gram-negative bacteria [44,48].…”

Section: Resistance To Chloramphenicol and Florfenicolmentioning

confidence: 99%

“…Genes, such as pp-flo and floR -coding for membrane-associated efflux systems which export chloramphenicol and florfenicol -have been detected on a plasmid in Photobacterium damselae subsp. piscicida [33] as part of a chromosomal multiresistance gene cluster in Salmonella enterica serovars Typhimurium [3,8] and Agona [18], but also on multiresistance plasmids of E. coli [17,32,77].…”

Section: Resistance To Chloramphenicol and Florfenicolmentioning

confidence: 99%

Use of antimicrobials in veterinary medicine and mechanisms of resistance

2001

View full text Add to dashboard Cite

-This review deals with the application of antimicrobial agents in veterinary medicine and food animal production and the possible consequences arising from the widespread and multipurpose use of antimicrobials. The various mechanisms that bacteria have developed to escape the inhibitory effects of the antimicrobials most frequently used in the veterinary field are reported in detail. Resistance of bacteria to tetracyclines, macrolide-lincosamide-streptogramin antibiotics, β-lactam antibiotics, aminoglycosides, sulfonamides, trimethoprim, fluoroquinolones and chloramphenicol/florfenicol is described with regard to enzymatic inactivation, decreased intracellular drug accumulation and modification/protection/replacement of the target sites. In addition, basic information is given about mobile genetic elements which carry the respective resistance genes, such as plasmids, transposons, and gene cassettes/integrons, and their ways of spreading via conjugation, mobilisation, transduction, and transformation.antibiotic therapy / growth promotion / resistance mechanism / resistance gene / gene transfer Résumé -Utilisation d'agents antimicrobiens en médecine vétérinaire et mécanismes de résis-tance. Cette revue présente les différents buts pour lesquels les agents antimicrobiens sont utilisés en médecine vétérinaire, dans les élevages d'animaux entrant dans la chaîne alimentaire et les possibles conséquences de cette large utilisation. Une synthèse est faite des différents mécanismes de résis-tance développés par les bactéries, comme l'inactivation enzymatique, la diminution de la concentration intracellulaire de l'antibiotique, les modification/protection/déplacement de cible, qui permettent d'échapper à l'action des antibiotiques les plus fréquemment utilisés dans le domaine vétérinaire :

show abstract

Detection of Florfenicol Resistance Genes in Escherichia coli Isolated from Sick Chickens

Cited by 132 publications

References 17 publications

Molecular characterization, spread and evolution of multidrug resistance in Salmonella enterica Typhimurium DT104

Molecular characterization, spread and evolution of multidrug resistance in Salmonella enterica Typhimurium DT104

Antimicrobial Resistance Genes in Enterotoxigenic Escherichia coli O149:K91 Isolates Obtained over a 23-Year Period from Pigs

Use of antimicrobials in veterinary medicine and mechanisms of resistance

Contact Info

Product

Resources

About