Detection of enteric viral and bacterial pathogens associated with paediatric diarrhoea in Goroka, Papua New Guinea

Soli, Kevin Webby; Maure, Tobias; Kas, Monalisa P.; Bande, Grace; Bebes, Sauli; Luang-Suarkia, Dagwin; Siba, Peter; Morita, Ayako; Umezaki, Masahiro; Greenhill, Andrew R.; Horwood, Paul F.

doi:10.1016/j.ijid.2014.02.023

Cited by 23 publications

(24 citation statements)

References 29 publications

(37 reference statements)

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“…Several authors suggest that rotavirus could be the main cause of enteric disease in rabbits and also be implicated as the etiological agent of severe enteric outbreaks 16,35 . Lavazza et al 14 identified rotavirus in rabbits by electron microscopy (16.0%), detecting 3.3% to 36.6% in humans 8,27,37 , our findings show the presence of rotavirus in fewer cases (10.3%). The concomitant identification of rotavirus and other pathogens was detected in 5/6 (83.3%) samples.…”

Section: Discussionsupporting

confidence: 55%

“…(26.6%), enteropathogenic E. coli (8.5%), Salmonella spp. were found below the limit of detection 27 .…”

Section: Discussionmentioning

confidence: 91%

“…within the epithelial cells of the intestine, alters the natural resistance barrier 30 , which is intensified due to various factors such as the production of inflammatory cytokines, mainly interleukin 6 (IL-6) and to a lesser degree interleukin 8 (IL-8) released as a result of massive cell lysis. These mechanisms are used by 27 . Further, some Eimeria species enhance host mucogenesis since the mucus layer of the gastrointestinal tract is an excellent source of nutrients for some bacteria 20 .…”

Section: Discussionmentioning

confidence: 99%

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Multicausal etiology of the enteric syndrome in rabbits from Mexico

Rubio

Gómez

Martínez-Castañeda

et al. 2017

Revista Argentina de Microbiología

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Enteropathies in rabbits are difficult to diagnose; their etiology involves pathogens that act synergistically, causing damage to the intestine. The aim of the present study was isolate enteric pathogens from rabbits in Mexico. Using parasitological, bacteriological and molecular analyses, we screened 58 samples of the intestinal content of rabbits having a clinical history of enteric disease from the southeastern part of the State of Mexico. Out of the 58 samples analyzed, a total of 86 identifications were made, Eimeria spp. were found in 77.5%, followed by Aeromonas spp. in 15.5% and Escherichia coli in 8.6%, which were identified as enteropathogenic E. coli (EPEC), and the presence of the following agents was also confirmed: Salmonella spp., Klebsiella spp., Streptococcus spp., Staphylococcus aureus, Enterococcus spp., Mannheimia spp. and Rotavirus. The concurrent presence of Eimeria spp. with Aeromonas was frequent (15.5%); there was statistical significance for the presence of an association between the clinical profiles and Eimeria spp. (p=0.000), Mannheimia spp. (p=0.001), Salmonella spp., Klebsiella spp., Streptococcus spp. and Enterococcus spp. (p=0.006).

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Section: Discussionsupporting

confidence: 55%

“…(26.6%), enteropathogenic E. coli (8.5%), Salmonella spp. were found below the limit of detection 27 .…”

Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

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Multicausal etiology of the enteric syndrome in rabbits from Mexico

Rubio

Gómez

Martínez-Castañeda

et al. 2017

Revista Argentina de Microbiología

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“…In this study, RoV coinfection was infrequent in younger children and peaked in infants between 7 and 12 months old. These results are comparable with the percentages of mixed infections detected in earlier reports, which found a prevalence of 2 % to 19 % [32][33][34]. The reason to this prevalence is the role of maternal antibodies in the protection of infants and the immunity acquired through previous exposure [23,29,35].…”

Section: Discussionsupporting

confidence: 90%

“…Consistent with previous studies, clinical presentation of patient with AGE is not generally indicative of a pathogen. It has been reported that symptoms, the length of hospitalization, and the number of diarrhea episodes are not significantly different for the different infectious agents [27,33,36].…”

Section: Discussionmentioning

confidence: 97%

Detection of rotavirus and other enteropathogens in children hospitalized with acute gastroenteritis in Havana, Cuba

et al. 2015

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The aim of the study was to diagnose infections with rotavirus and other enteric pathogens in children under five years old with acute gastroenteritis and to identify the most common epidemiological and clinical characteristics of these pathogens. The study was conducted using 110 stool samples from the same number of children under five years old who were inpatients at three paediatric hospitals in Havana, Cuba, between October and December 2011. The samples were tested for rotavirus and other enteric pathogens using traditional and molecular microbiological methods. Pathogens were detected in 85 (77.3 %) of the children. Rotavirus was the most commonly found, appearing in 54.5 % of the children, followed by bacteria (29 %) and parasites (10.9 %). Other viral pathogens detected included adenovirus (6.4 %) and astrovirus (3.6 %). In rotavirus-positives cases, at least one other pathogen was detected, usually a bacterium (26.6 %). More than three episodes of watery diarrhea in 24 hours were observed in 78.3 % of the cases. Dehydration was found in 30 (50 %) rotavirus-positive children, of whom seven (11.6 %) were transferred to an intensive care unit due to complications of metabolic acidosis. Rotavirus was most commonly observed among children under 12 months old (65 %). The highest incidence of infection occurred in children who were under the care of a relative at home (78.3 %), had not been breastfed (65 %), or had been breastfed for less than six months (28.3 %). The genotype combinations most frequently found were G9P8 (28.3 %) and G1P8 (10 %). This study demonstrates the presence of rotavirus and other enteric pathogens as causes of gastroenteritis in hospitalized infants and young children in Cuba.

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Global molecular prevalence and genotype distribution of Sapovirus in children with gastrointestinal complications: A systematic review and meta‐analysis

Razizadeh

Khatami

Zarei

2021

Reviews in Medical Virology

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Sapovirus (SaV) is an emerging cause of children gastrointestinal complications such as acute gastroenteritis (AGE). The aim of the present systematic review and metaanalysis was to estimate the global prevalence of the SaV in children and association of infection with SaVs and AGE in children based on case-control studies. Four international databases (PubMed, Scopus, Web of Sciences and Google Scholar) were used to retrieve English-language studies published between January 2000 and December 2020. Comprehensive Meta-Analysis software was applied to estimate the overall prevalence, publication bias and heterogeneity index. The pooled prevalence of SaV infection among children with gastroenteritis was 3.4% [95% confidence interval (CI): 2.9%-3.9%] based on a random-effects meta-analysis.Genogroup I was the dominant genogroup of SaV in children with gastroenteritis [2.2% (95% CI: 1.6%-3.0%)], association analysis showed that SaV was associated with gastroenteritis [OR: 1.843 (95% CI: 1.27-2.66)]. Given the significant prevalence of the virus in children, it is necessary to pay more attention to this situation.Therefore, preventive health measures in children should be a priority.

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Detection of enteric viral and bacterial pathogens associated with paediatric diarrhoea in Goroka, Papua New Guinea

Abstract: This study demonstrates that Shigella and rotavirus are the major pathogens associated with acute paediatric gastroenteritis in this setting.

Cited by 23 publications

References 29 publications

Multicausal etiology of the enteric syndrome in rabbits from Mexico

Multicausal etiology of the enteric syndrome in rabbits from Mexico

Detection of rotavirus and other enteropathogens in children hospitalized with acute gastroenteritis in Havana, Cuba

Global molecular prevalence and genotype distribution of Sapovirus in children with gastrointestinal complications: A systematic review and meta‐analysis

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