1982
DOI: 10.1016/0014-2999(82)90175-3
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Detection and comparative evaluation of aldosterone antagonists in glucocorticoid-treated, adrenalectomized rats

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Cited by 5 publications
(1 citation statement)
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“…This might be explained by an insufficient MRA dose, leading to a weak antimineralocorticoid effect. Moreover, spironolactone (as with all oral diuretic therapies) has a delayed effect in healthy individuals (48 hours) [11], which is even more pronounced in patients with AHF [12]. The antimineralocorticoid effect of spironolactone may occur too late [10].…”
Section: Introductionmentioning
confidence: 99%
“…This might be explained by an insufficient MRA dose, leading to a weak antimineralocorticoid effect. Moreover, spironolactone (as with all oral diuretic therapies) has a delayed effect in healthy individuals (48 hours) [11], which is even more pronounced in patients with AHF [12]. The antimineralocorticoid effect of spironolactone may occur too late [10].…”
Section: Introductionmentioning
confidence: 99%