2019
DOI: 10.1016/j.ijid.2019.06.027
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Abstract: Background: Hepatitis E virus genotype 3 (HEV-3) infection usually causes self-limited acute hepatitis. In immunosuppressed patients, HEV-3 infection can rapidly progress to chronic hepatitis and cirrhosis. In southern Brazil, data on HEV seroprevalence are scarce. Methods: Testing for HEV RNA and antibodies (anti-HEV) was performed for 320 HIV-infected patients followed at the HIV/AIDS Service of the Federal University of Rio Grande between 2012 and 2013, as well as 281 blood donor samples obtained in 2015. V… Show more

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Cited by 21 publications
(20 citation statements)
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“…Very recently, studies from southern Brazil and northern Argentina have reported seroprevalence rates of 7% to 10%, and 9%, respectively. 16,17 In addition, anti-HEV Ig prevalence in blood donors from this study was found to increase with age, a finding that is in concordance with previous data published elsewhere. 16,18 On the other hand, it may be noted that severe discrepancies and the existence of wide variability in terms of sensitivity and specificity have been reported for commercially available serologic tests.…”
Section: Discussionsupporting
confidence: 93%
See 3 more Smart Citations
“…Very recently, studies from southern Brazil and northern Argentina have reported seroprevalence rates of 7% to 10%, and 9%, respectively. 16,17 In addition, anti-HEV Ig prevalence in blood donors from this study was found to increase with age, a finding that is in concordance with previous data published elsewhere. 16,18 On the other hand, it may be noted that severe discrepancies and the existence of wide variability in terms of sensitivity and specificity have been reported for commercially available serologic tests.…”
Section: Discussionsupporting
confidence: 93%
“…Similar HEV‐seropositive rates among blood donors were described in the region in the last 2 years. Very recently, studies from southern Brazil and northern Argentina have reported seroprevalence rates of 7% to 10%, and 9%, respectively 16,17 . In addition, anti‐HEV Ig prevalence in blood donors from this study was found to increase with age, a finding that is in concordance with previous data published elsewhere 16,18 …”
Section: Discussionsupporting
confidence: 92%
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“…11 Though Hepatitis D is rarer than other strains at a prevalence of 0.80% and 13.02% among Hepatitis B carriers, there is estimated to be 48-60 million infections globally, with a progression to cirrhosis within 5 year and hepatocellular carcinoma within 10 years. 12 Out of all the strains Hepatitis E remains the least understood especially in third world counties, such as Brazil 13 , Central African Republic 14 , Nigeria 15 , Nepal 16 , and India. 17 There is limited treatment for acute hepatitis E, but chronic in the immunosuppressed can be treated with ribavirin, and people living in China can be vaccinated against hepatitis E, but the vaccine is not widespread.…”
Section: Discussionmentioning
confidence: 99%