Detecting the skewness of data from the sample size and the five-number summary

Shi, Jiandong; Luo, Dehui; Wan, Xiang; Liu, Yue; Liu, Jiming; Bian, Zhaoxiang; Tong, Tiejun

doi:10.48550/arxiv.2010.05749

Cited by 16 publications

(12 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We calculated the mean difference in continuous variables for treatment effect measurement while the odds ratio was calculated for discrete variables. Where medians and interquartile ranges were reported, they were assessed for skewness and whether the data were similar to a normal distribution, and the mean and standard deviation were imputed [ 9 , 10 , 11 ]. Standard errors were calculated using a 95% confidence interval, and a p -value of 0.05 was used to determine statistical significance.…”

Section: Methodsmentioning

confidence: 99%

The Role and Efficacy of Vitamin C in Sepsis: A Systematic Review and Meta-Analysis

Muhammad¹,

Kassem

Sattar

et al. 2022

Advances in Respiratory Medicine

View full text Add to dashboard Cite

Clinical rationale for study: Despite advancements in critical care, the mortality rate of sepsis remains high, with an overall poor prognosis. There is a complex pathophysiology of a lethal cascade of cytokines and inflammatory proteins underlying sepsis. The use of vitamin C can theoretically suppress the inflammatory cascade but remains a questionable practice due to a lack of conclusive evidence. Aims of the study: To appraise the therapeutic role of vitamin C in sepsis. Materials and methods: A systematic review was conducted on PubMed, Embase, and the Central Cochrane Registry. The study included randomized clinical trials (RCTs) with vitamin C as an intervention arm in the septic patient population. For continuous variables, the difference in means (MD) and for discrete variables, the odds ratio (OR) was used. For effect sizes, a confidence interval of 95% was used. A p-value of less than 0.05 was used for statistical significance. The analysis was performed using a random-effects model irrespective of heterogeneity. Heterogeneity was evaluated using the I2 statistic. Results: 23 studies were included with the total sample size of 2712 patients. In patients treated with vitamin C, there was a statistically significant reduction in the mortality: OR = 0.778 (0.635 to 0.954), p = 0.016; the sequential organ failure assessment score (SOFA): MD = −0.749 (−1.115 to −0.383), p < 0.001; and the duration of vasopressor requirement: MD = −1.034 days (−1.622 to −0.445), p = 0.001. No significant difference was found in the hospital or ICU length of stay. Conclusions and clinical implications: Vitamin C treatment regimens were associated with reduced mortality, SOFA score, and vasopressor requirement compared to the control in sepsis. Given its low cost and minimal adverse effects, we strongly encourage further large, randomized trials to establish vitamin C as a standard of care in sepsis management.

show abstract

Section: Methodsmentioning

confidence: 99%

The Role and Efficacy of Vitamin C in Sepsis: A Systematic Review and Meta-Analysis

Muhammad¹,

Kassem

Sattar

et al. 2022

Advances in Respiratory Medicine

View full text Add to dashboard Cite

show abstract

“…Weighted mean difference (MD) and 95% CI were calculated for the continuous outcome. LLL was reported as a median value with an interquartile range in Vos et al [7], a specific function algorithm was performed to calculate the mean and standard deviation [12][13][14][15]. Estimates and 95% CIs were graphically presented using Forest plots [16].…”

Section: Discussionmentioning

confidence: 99%

Comparison of Drug-Coated Balloons and Drug-Eluting Stents in Primary Percutaneous Coronary Interventions for ST-Segment Elevated Myocardial Infarction: A Systemic Review and Meta-Analysis

Hu¹,

Li²,

Liu³

et al. 2022

Rev. Cardiovasc. Med.

View full text Add to dashboard Cite

Background:The most optimal strategy for ST-segment elevation myocardial infarction (STEMI) between drug-eluting stents (DES) and drug-coated balloons (DEB) is still unknown. This meta-analysis aims to compare the short-term outcomes of both methods in patients with STEMI. Methods: We searched PubMed, Web of Science, EMBASE, and the Cochrane Library Databases for eligible studies with publication data from 2015 to Jan 2022. Four trials with 360 patients were included. The study was conducted by following the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statements. Results: There were no significant differences in major adverse cardiac events between DCB and DES during 6 to 12 months of follow-up (RR 1.38, 95% CI: 0.65 to 2.93; p = 0.41). Similar risks of myocardial infarction (RR 0.48, 95% CI: 0.11 to 2.11, p = 0.33), all causes of death (RR 1.55, 95% CI: 0.32 to 7.62, p = 0.59), and target lesion revascularization (RR 1.29, 95% CI: 0.55 to 3.04, p = 0.55) were observed. The pooled results indicated that DCB was comparable to DES in terms of late lumen loss with a mean difference (MD) of -0.06 mm with significant heterogeneity (95% CI: -0.25 to 0.13, p = 0.54, I 2 = 85%). Subsequent subgroup analysis based on the study design revealed that late lumen loss was significantly lower in the drug-coated balloon group in randomized controlled trials (MD -0.16, 95% CI: -0.26 to -0.05, p = 0.003). Conclusions: Drug-coated balloons were associated with similar risks of MACE compared with drug-eluting stents in the setting of STEMI. However, a larger randomized controlled trial is required to confirm these observations.

show abstract

“…For the SELENOP concentration, data were expressed as the means and standard deviations (SDs); otherwise, the reported standard error (SE), median and interquartile range, or geometric mean and SE were converted to the expression by the corresponding formula [ 35 , 36 , 37 , 38 ]. For the correlation between SELENOP and GLM indicators, data were expressed as PCC, and SCC was converted to PCC using an appropriate method [ 39 ].…”

Section: Methodsmentioning

confidence: 99%

Associations between Circulating SELENOP Level and Disorders of Glucose and Lipid Metabolism: A Meta-Analysis

Wang

et al. 2022

Antioxidants

View full text Add to dashboard Cite

Selenoprotein P (SELENOP) is an extracellular antioxidant, selenium transporter, and hepatokine interfering with glucose and lipid metabolism. To study the association between the circulating SELENOP concentration and glucose and lipid metabolic diseases (GLMDs), including gestational diabetes (GD), metabolic syndrome (MetS), non-alcoholic fatty liver disease, obesity, and type 2 diabetes, as well as the individual markers, a meta-analysis was conducted by searching multiple databases from their establishment through March 2022 and including 27 articles published between October 2010 and May 2021, involving 4033 participants. Participants with GLMDs had higher levels of SELENOP than those without GLMDs (standardized mean difference = 0.84, 95% CI: 0.16 to 1.51), and the SELENOP levels were positively correlated with the markers of GLMDs (pooled effect size = 0.09, 95% CI: 0.02 to 0.15). Subgroup analyses showed that the SELENOP concentrations were higher in women with GD and lower in individuals with MetS than their counterparts, respectively. Moreover, SELENOP was positively correlated with low-density lipoprotein cholesterol, but not with the other markers of GLMDs. Thus, the heterogenicity derived from diseases or disease markers should be carefully considered while interpreting the overall positive association between SELENOP and GLMDs. Studies with a larger sample size and advanced design are warranted to confirm these findings.

show abstract

Detecting the skewness of data from the sample size and the five-number summary

Cited by 16 publications

References 22 publications

The Role and Efficacy of Vitamin C in Sepsis: A Systematic Review and Meta-Analysis

The Role and Efficacy of Vitamin C in Sepsis: A Systematic Review and Meta-Analysis

Comparison of Drug-Coated Balloons and Drug-Eluting Stents in Primary Percutaneous Coronary Interventions for ST-Segment Elevated Myocardial Infarction: A Systemic Review and Meta-Analysis

Associations between Circulating SELENOP Level and Disorders of Glucose and Lipid Metabolism: A Meta-Analysis

Contact Info

Product

Resources

About