Destruction of the stem cell Niche, Pathogenesis and Promising Treatment Targets for Primary Scarring Alopecias

Halley-Stott, Richard P.; Adeola, Henry Ademola; Khumalo, Nonhlanhla P.

doi:10.1007/s12015-020-09985-6

Cited by 4 publications

(1 citation statement)

References 102 publications

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“…It represents a sign of beauty and a sign of well-being since long time, so the abnormal loss of hair represents a devastating issue that leads to psychological disturbances. 17 The treatment of this condition is challenging for many physicians due to its variable etiologies, lack of safety and effectiveness of many of the available treatment approaches that mandate continuous search for drugs and treatment options with more promising outcomes. 1 Hair growth promotion occurs via the induction of anagen (active growth) phase that leans on angiogenesis induction to meet the enhanced nutritional and oxygen demands of the rapidly dividing cells of hair follicles that occur during anagen phase of hair growth cycle, vasodilator as minoxidil causes hypertrichosis and improves hair growth via improving the cutaneous blood flow to the scalp.…”

Section: Discussionmentioning

confidence: 99%

In vivo Study of the Effect of 5 and 10% Nebivolol Cream on Hair Growth in Mice Models

R.¹,

Raghif²,

Mahdi³

2022

IJDDT

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Background: Hair growth promotion via the use of vasodilators represents an important approach in hair loss management as they have proven to be effective in promoting hair growth. Nebivolol is a potent vasodilator which also exhibits anti-apoptotic, anti-inflammatory, and antioxidant effects, yet its role in hair growth induction is not well known. Objective: The present study aims to investigate hair growth-promoting effect of the topical application of nebivolol cream in two strengths 5 and 10% in mice models. Methods: Active hair growth (Anagen) induction by the topical use of nebivolol cream has been evaluated in mouse model. Fifty male swiss albino mice (8 weeks aged) dorsal skins were shaved and these mice were divided randomly and equally into untreated control group with which other experimental groups compression was done and 4 treated groups (n=10) with nebivolol 5% cream, nebivolol 10% cream, minoxidil 2% topical solution and vehicle (1:1 vaseline and lanoline).

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Section: Discussionmentioning

confidence: 99%

In vivo Study of the Effect of 5 and 10% Nebivolol Cream on Hair Growth in Mice Models

R.¹,

Raghif²,

Mahdi³

2022

IJDDT

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Cellular Heterogeneity Facilitates the Functional Differences Between Hair Follicle Dermal Sheath Cells and Dermal Papilla Cells: A New Classification System for Mesenchymal Cells within the Hair Follicle Niche

Gan

Wang

et al. 2022

Stem Cell Rev and Rep

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An Updated Etiology of Hair Loss and the New Cosmeceutical Paradigm in Therapy: Clearing ‘the Big Eight Strikes’

Sadgrove

Batra²,

Barreto³

et al. 2023

Cosmetics

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In this current review, research spanning the last decade (such as transcriptomic studies, phenotypic observations, and confirmed comorbidities) has been synthesized into an updated etiology of hair loss and applied to the new cosmeceutical paradigm of hair rejuvenation. The major etiological components in scalps with hair loss are denoted as the ‘big eight strikes’, which include the following: androgens, prostaglandins, overactive aerobic metabolism of glucose, bacterial or fungal over-colonization, inflammation, fibrosis, metabolism or circulation problems, and malnutrition. The relevance of the ‘big eight’ to nine categories of hair loss is explained. In cases of androgenetic alopecia or female pattern hair loss, both elevated DHT and increased frequency of androgen receptors lead to problems with the metabolism of glucose (sugar), redox imbalance, disruption to the electron transport chain, and PPAR-γ overactivity (the latter is unique to androgenetic alopecia, where the reverse occurs in other types of hair loss). These etiological factors and others from ‘the big eight’ are the focal point of our hypothetical narrative of the attenuative mechanisms of commercial cosmeceutical hair serums. We conclude that cosmeceuticals with the potential to improve all eight strikes (according to published in vitro or clinical data) utilize bioactive peptides and plant compounds that are either flavonoids (isoflavones, procyanidins, flavanols, and flavonols) or sterols/triterpenes. It is noteworthy that many therapeutic interventions are generic to the multiple types of hair loss. Lastly, suggestions are made on how scalp and hair health can be improved by following the cosmeceutical approach.

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Destruction of the stem cell Niche, Pathogenesis and Promising Treatment Targets for Primary Scarring Alopecias

Cited by 4 publications

References 102 publications

In vivo Study of the Effect of 5 and 10% Nebivolol Cream on Hair Growth in Mice Models

In vivo Study of the Effect of 5 and 10% Nebivolol Cream on Hair Growth in Mice Models

Cellular Heterogeneity Facilitates the Functional Differences Between Hair Follicle Dermal Sheath Cells and Dermal Papilla Cells: A New Classification System for Mesenchymal Cells within the Hair Follicle Niche

An Updated Etiology of Hair Loss and the New Cosmeceutical Paradigm in Therapy: Clearing ‘the Big Eight Strikes’

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