Desmoplastic melanoma associated with an intraepidermal lentiginous lesion: case report and literature review

Junior, Cesar de Souza Bastos; Piñeiro-Maceira, Juãn; Moraes, Fernando Manuel Belles de

doi:10.1590/abd1806-4841.20131817

Cited by 7 publications

(9 citation statements)

References 16 publications

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“…Lentigo malignant melanoma is a common type of melanoma associated with desmoplasia followed by superficial spreading melanoma and atypical lentiginous hyperplasia. [ 2 ] When the neurotrophic desmoplastic melanoma involves the head and neck region, it can involve the trigeminal nerve and facial nerve.…”

Section: Discussionmentioning

confidence: 99%

An unusual case of desmoplastic malignant melanoma

Pandiaraja¹,

Subramanian²

2015

J Cutan Aesthet Surg

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Desmoplastic malignant melanoma is a rare variant of spindle cell melanoma, commonly seen in older adults, on sun-exposed areas. It accounts for 1-4% of all cases of cutaneous melanoma. The common location of the desmoplastic melanoma is the head and neck region, whereas, other sites are less common. Regional lymph node involvement is reported in 0 to 13.7% of the cases, which is less frequent than other cutaneous melanomas. A 75-year-old male presented with an ulceroproliferative growth on the left foot that was diagnosed as desmoplastic melanoma with regional lymph node metastasis and in transit metastasis, with extensive pulmonary metastasis.

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Section: Discussionmentioning

confidence: 99%

An unusual case of desmoplastic malignant melanoma

Pandiaraja¹,

Subramanian²

2015

J Cutan Aesthet Surg

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“…Desmoplastic melanoma (DM) is a rare variant, representing less than 4% of cutaneous melanomas, with a global incidence of two cases per one million inhabitants. 1-4 Since its description in 1971 by Conley et al . until a survey in 2009, approximately 1,100 cases were published worldwide.…”

Section: Introductionmentioning

confidence: 99%

“…DM is a fibrous tumor, characterized histologically by the proliferation of fusiform melanocytes in the dermis, with variable degrees of stromal collagen deposits (desmoplasia). 1-4 The neoplastic cells are frequently depigmented and display mild to severe nuclear atypia, sometimes with neurotropism and neural differentiation. 1-4 Immunohistochemistry is positive for protein S-100, the most useful marker for diagnosis of DM due to its high sensitivity, with nuclear and cytoplasmic marking in 97% to 100% of cases.…”

Section: Introductionmentioning

confidence: 99%

“…1-4 The neoplastic cells are frequently depigmented and display mild to severe nuclear atypia, sometimes with neurotropism and neural differentiation. 1-4 Immunohistochemistry is positive for protein S-100, the most useful marker for diagnosis of DM due to its high sensitivity, with nuclear and cytoplasmic marking in 97% to 100% of cases. 1-6…”

Section: Introductionmentioning

confidence: 99%

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Desmoplastic melanoma: a rare variant with challenging diagnosis

Marques

Diniz

Spelta

et al. 2019

An. Bras. Dermatol.

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Desmoplastic melanoma, a distinct and uncommon variant, is characterized as an invasive lesion with proliferation of fusiform melanocytes in the dermis and subcutaneous tissue, associated with varying patterns of desmoplasia. Neurotropism and neural differentiation may occur. The clinical presentation is variable and nonspecific, easily confused with other fibrous neoplasms. The disease is locally aggressive and shows lower metastasis rates than other types of melanoma. Histopathology may be insufficient, requiring positive immunohistochemistry for S-100 protein and other antigens of melanocytic differentiation. Because desmoplastic melanoma represents a true clinical, dermoscopic, and histopathological diagnostic challenge, a case of invasive desmoplastic melanoma is reported, affecting a photoexposed area in an elderly woman after histological revisions and an initial diagnosis of fibroma.

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“…Desmoplastic melanoma (DM) is a rare form of malignant melanoma, accounting for less than 4% of all primary melanomas often associated with lentigo maligna (Bastos Junior et al, 2013). Due to its amelanotic and atypical appearance it is commonly mistaken for a benign tumor, an inflammatory condition or non-melanocytic spindle cell proliferation including squamous cell carcinoma and dermatofibroma.…”

Section: Introductionmentioning

confidence: 99%

Unmasking of a primary desmoplastic melanoma tumour in the course of treatment of a metastatic disease with anti‐PD‐1 monoclonal antibody

Richtig

Ramelyte

Koch

et al. 2019

Acad Dermatol Venereol

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Atypical forms of SS can present with subcutaneous nodules, ulcerative necrotizing lesions and bullae. 1,2 bSS is rare and has to be differentiated from other diseases like contact dermatitis, drug-induced eruptions or autoimmune bullous diseases, particularly when palms and soles are affected. 3 bSS can be idiopathic although it has been mainly reported to be associated with neoplasms and, to a lesser extent, with infections, drug intake and active IBDs. 4-8 In bSS, the neutrophilic exocytosis is massive and is associated with a more intense dermal oedema leading to a subepidermal detachment. 9 The resolution of bullous lesions does not result in scars; 2 in our patient, only a postinflammatory hyperpigmentation was present after the remission of the skin eruption. Our case is peculiar for the clinical presentation with very large tense blisters that is unusual for SS. Furthermore, it is noteworthy that the underlying UC was inactive. Actually, IBDs are the systemic diseases most commonly associated with classical form of SS, 2 that belongs to the so-called 'reactive' cutaneous extraintestinal manifestations of IBDs, a group of skin diseases that are believed to share common pathogenic mechanisms with the underlying intestinal disease, but without exhibiting the same histopathologic features. 10 Although immune-mediated pathogenic mechanisms have been suggested for the association of SS and IBDs, the link between the two conditions is still unknown. 10 The occurrence of SS is more frequent in active IBDs: only four cases of SS have been reported in association with inactive IBDs (two patients with CD and two patients with UC). 8,11 It could be hypothesized that in our case the prompt start of high-dose steroid therapy could have prevented reactivation of the intestinal disease. On the other hand, an accidental association cannot be excluded. Our case is unique for the uncommon bullous presentation and for the association with iUC. Despite its rarity, it is important to consider this atypical variant for a proper diagnostic and therapeutic approach. Furthermore, patients should be followed up in order to detect any exacerbation of UC and to early diagnose any malignancy that may arise even after years from SS's onset, as already reported in the literature. 1

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Desmoplastic melanoma associated with an intraepidermal lentiginous lesion: case report and literature review

Cited by 7 publications

References 16 publications

An unusual case of desmoplastic malignant melanoma

An unusual case of desmoplastic malignant melanoma

Desmoplastic melanoma: a rare variant with challenging diagnosis

Unmasking of a primary desmoplastic melanoma tumour in the course of treatment of a metastatic disease with anti‐PD‐1 monoclonal antibody

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