An unusual case of desmoplastic malignant melanoma

Abstract

Desmoplastic malignant melanoma is a rare variant of spindle cell melanoma, commonly seen in older adults, on sun-exposed areas. It accounts for 1-4% of all cases of cutaneous melanoma. The common location of the desmoplastic melanoma is the head and neck region, whereas, other sites are less common. Regional lymph node involvement is reported in 0 to 13.7% of the cases, which is less frequent than other cutaneous melanomas. A 75-year-old male presented with an ulceroproliferative growth on the left foot that was diagnosed as desmoplastic melanoma with regional lymph node metastasis and in transit metastasis, with extensive pulmonary metastasis.

A case of recurrent desmoplastic malignant melanoma presenting as empyema with underlying lung mass

“…In contrast to NDMM, which may spread to distant sites, DMM exhibits a more sarcomatoid local recurrence pattern. Regional lymph node involvement is detected up to 13.7% of the time in pure and mixed DMM [ 6 ]. Strong and diffuse S100 and SOX10 immunohistochemical staining was observed in this case, which is necessary to confirm the diagnosis, since conventional melanocyte-specific markers (Melan A and HMB45) are characteristically negative in DMM ( 4 , Fig.…”

An update in the management of malignant melanoma

“…Malignant melanoma is one of the most dangerous forms of cutaneous malignancies [1] . It is classified as cutaneous melanoma and non-cutaneous melanoma based on the location of the lesion.…”