Desmoid Tumor of the Breast Following Augmentation Mammaplasty

Schuh, Marlys E.; Radford, Diane M.

doi:10.1097/00006534-199403000-00028

Cited by 16 publications

(3 citation statements)

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“…In un nostro caso (caso n. 4), la fibromatosi insorgeva nella stessa sede di pregressa exeresi di un lipoma intrammario. Sebbene sia noto che le fibromatosi possano originare come lesioni reattive in seguito a traumi o interventi chirurgici [1], soltanto in 11 casi di FM (incluso il nostro) è stato possibile correlare l'insorgenza della patologia con un pregresso trauma mammario [3,6,12,[32][33][34][35][36]; ciò evidentemente suggerisce come la FM possa insorgere indipendentemente da traumi meccanici, i quali, come ampiamente noto, in questa sede sono per lo più responsabili di focolai di citosteatonecrosi e/o di fibrosi di tipo cicatriziale.…”

Section: Discussioneunclassified

Fibromatosis of the breast: a clinical, radiological and pathological study of a series of six cases

Magro

Gurrera²,

Scavo³

et al. 2002

Pathologica

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We describe the clinical, radiological and pathological features of a series of six cases of primary fibromatosis of the breast. Most patients (5 of 6) were women of 22-58 years of age; one case occurred in a 47-year-old man. The fibromatosis of the breast in all cases presented as a monolateral solid nodule, clinically suspicious for malignancy and in three cases was also associated with cutaneous and/or nipple retraction. None of the patients was affected by any genetic disorder characterized by fibromatoses involving multiple sites, including breast. Both echographic and mammographic examinations revealed solid masses with irregular margins but without calcifications, mimicking scirrhous carcinoma. All cases were surgically treated by lumpectomy (4 of 6) or quadrantectomy (2 of 6), and after a follow-up period ranging from 5 months to 13 years all patients are well and disease-free. Histological examination revealed finger-like infiltrating margins entrapping adjacent breast parenchyma and adipose tissue in all cases. The hallmark of the lesion was the presence of bland-looking spindle cells, with a low mitotic index, organized in long sweeping and intersecting fascicles. Three different morphological phases (i.e. proliferative, involutional and residual), identical to those observed in Dupuytren's superficial fibromatosis, variably coexisted in each case. At immunohistochemistry the cells which comprised the lesion exhibited a diffuse expression of vimentin and a heterogeneous immunoreactivity to a-smooth muscle actin, thus confirming their fibro-myofibroblastic nature. No expression of estrogen, progesterone or androgen receptors or of pS2 correlated-estrogen protein was observed. We discuss both the pathogenesis of the mammary fibromatosis, pointing to the fibroblastic cells of the mammary stroma as the putative precursors, and the differential diagnosis versus the bland-looking, monomorphic spindle cell tumor-like or tumorous lesions of the breast.

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Section: Discussioneunclassified

Fibromatosis of the breast: a clinical, radiological and pathological study of a series of six cases

Magro

Gurrera²,

Scavo³

et al. 2002

Pathologica

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“…Many patients report a history of minor trauma to the breast or prior breast surgery. There is some association between augmentation mammoplasty and the development of fibromatosis in the capsule around the breast implant (16). On mammograms, fibromatosis appears as a round or irregular noncalcified mass, usually with indistinct margins or marginal spiculation (Fig 18).…”

Section: Fibromatosismentioning

confidence: 99%

Fibrous Lesions of the Breast: Imaging-Pathologic Correlation

Goel¹,

Knight²,

Pandey³

et al. 2005

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Fibroepithelial lesions of the breast are commonly seen in clinical practice. The masses are composed of a combination of prominent stroma and varying glandular elements. Fibroadenomas, benign lesions that derive from the terminal duct lobular unit, are the most common and are often identified at clinical examination or mammography as circumscribed masses. Benign mesenchymal tumors include focal fibrosis, pseudoangiomatous stromal hyperplasia, and fibromatosis or desmoid tumor. Phyllodes tumor, which is similar to fibroadenoma but has increased cellularity in the stroma, is typically benign but has malignant potential. Diabetic fibrous mastopathy, a stromal proliferation found in patients with juvenile-onset insulin-dependent diabetes, is a reactive fibrous lesion. Most of these lesions manifest as masses at clinical and/or mammographic examination. Some (eg, fibroadenomas) may be associated with calcifications. Except for fibromatosis and phyllodes tumor, fibroepithelial lesions need not be excised if the diagnosis is confirmed by the results of histologic analysis at percutaneous biopsy. To correctly differentiate between fibrous breast lesions that are benign and those that should be resected, the physician must be familiar with the correlated radiologic-pathologic findings in the various lesion types.

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“…Most are fibromatoses [1][2][3][4][5][6][7][8][9][10][11], and the remaining cases are sarcomas of various types, including stromal sarcoma, angiosarcoma, fibrosarcoma, and malignant fibrous histiocytoma [12][13][14][15][16]. To date, there has been no systematic analysis of these lesions using current diagnostic criteria to determine if the tumors can be linked to implant type or rupture and whether the balance of evidence supports a fortuitous or causal association-a debate that has potential litigious implications.…”

Section: Introductionmentioning

confidence: 99%