Designing of fatty acid-surfactant conjugate based nanomicelles of morin hydrate for simultaneously enhancing anticancer activity and oral bioavailability

Jangid, Ashok Kumar; Agraval, Hina; Gupta, Nitin; Yadav, Umesh C.S.; Sistla, Ramakrishna; Pooja, Deep; Kulhari, Hitesh

doi:10.1016/j.colsurfb.2018.11.073

Cited by 42 publications

(17 citation statements)

References 37 publications

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“…Morin hydrate is a naturally occurring polyphenolic flavonol compound which is an isomeric form of quercetin. It has been recently investigated for its many biological activities, such as anti-inflammatory, antioxidant, and as well as anticancer [28,29]. In our study, we investigated the influence of morin hydrate on viability and clonogenicity of A2780 and SKOV-3 cells.…”

Section: Discussionmentioning

confidence: 99%

Morin exerts anti-metastatic, anti-proliferative and anti-adhesive effect in ovarian cancer cells: an in vitro studies

2020

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The influence of morin hydrate on changes of proliferative, metastatic, and adhesive potential of human ovarian cancer cells concerning the influence of decitabine, and decitabine with trichostatin A, and in comparison to untreated cells, were analyzed. The effect of morin hydrate, decitabine, and trichostatin A were examined in A2780 and SKOV-3 ovarian cancer cell lines using MTS assay, clonogenic assay, adhesion to endothelial HMEC-1 cells, transwell migration assay and cell cycle analysis. The expression level of epithelial to mesenchymal transition (EMT) markers was quantified using PCR Array in relation to the level of global methylation determined with Methylated DNA Quantification Kit. We observed statistically significant inhibition of adhesive and migratory potential of both cell lines and the accumulation of G0/G1 phase A2780 cells after treatment with morin hydrate. Our studies confirmed the influence of morin hydrate on down-regulation of genes considered as up-regulated during EMT, and up-regulation of some genes considered as down-regulated during EMT in A2780 and SKOV-3 cells. Phenotypic changes were associated with molecular changes in cells, eg. decrease of the expression level of genes associated with adhesion, and an increase of genes down-regulated during EMT, after morin hydrate treatment in comparison to untreated control cells in both cell lines, were observed. Keywords Adhesion • Epithelial to mesenchymal transition • Metastasis • Morin hydrate • Ovarian cancer cells Abbreviations ATCC American type culture collection DNMT DNA methyltransferase ECACC European collection of authenticated cell cultures ECM Extracellular matrix EMT Epithelial to mesenchymal transition EOC Epithelial ovarian cancer HAT Histone acetyltransferase HDAC Histone deacetylase MET Mesenchymal to epithelial transition SAM S-sdenosyl-l-methionine TSA Trichostatin A

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Section: Discussionmentioning

confidence: 99%

Morin exerts anti-metastatic, anti-proliferative and anti-adhesive effect in ovarian cancer cells: an in vitro studies

2020

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“…There are few studies on the stability of morin, but the effect of oral morin is very poor, indicating that the state of oral morin is not stable [37], so intravenous injection may become an important direction for its research and application. Although the oral effect of morin can be greatly improved after some modification, whether it is convenient for large-scale production and development remains to be studied [38]. In addition, some studies have shown that morin also has potential therapeutic effects in the treatment of Staphylococcus aureus and Streptococcus suis infections [39,40], suggesting that morin has potential as a broad-spectrum agent for the treatment of bacterial infections.…”

Section: Discussionmentioning

confidence: 99%

Morin inhibits Listeria monocytogenes virulence in vivo and in vitro by targeting listeriolysin O and inflammation

Wang

et al. 2020

Preprint

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Background: Listeria monocytogenes (L. monocytogenes) is a global opportunistic intracellular pathogen that can cause many diseases, including meningitis and abortion in humans and animals; thus, L. monocytogenes poses a great threat to public safety and the development of the aquaculture industry. The pore-forming toxin listeriolysin O (LLO) is one of the most important virulence factors of L. monocytogenes; LLO can promote cytosolic bacterial proliferation and aid in evading the attacks of the host immune system. In addition, L. monocytogenes infection can trigger a series of severe inflammatory reactions.Results: Here, on the basis of our previous studies, we further confirmed that morin lacking anti-Listeria activity could inhibit LLO oligomerization and found that morin could effectively alleviate the inflammation induced by Listeria in vivo and in vitro and has an obvious protective effect on infected cells and mice.Conclusions: Thus, we further prove that morin is a valuable drug precursor to be developed for the treatment of Listeria infection.

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“…The critical micelle concentration (CMC) of F68-PTX conjugates was determined using pyrene uorescence method. 35,36 The aqueous solutions of different concentrations of F68-PTX conjugates (50 to 600 mg mL À1 ) were equilibrated with a xed pyrene concentration 6 Â 10 À7 M and maintained at RT for 3 h. The uorescence intensities were measured at 383 and 373 nm aer excitation at 339 nm. The wavelength intensities ratio I 383 / I 373 was plotted against log concentrations of F68-PTX (mg mL À1 ) to determine the CMC.…”

Section: Critical Micelle Concentration Of F68-ptx Conjugatementioning

confidence: 99%

Self-assembled and pH-responsive polymeric nanomicelles impart effective delivery of paclitaxel to cancer cells

et al. 2021

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Designing of fatty acid-surfactant conjugate based nanomicelles of morin hydrate for simultaneously enhancing anticancer activity and oral bioavailability

Cited by 42 publications

References 37 publications

Morin exerts anti-metastatic, anti-proliferative and anti-adhesive effect in ovarian cancer cells: an in vitro studies

Morin exerts anti-metastatic, anti-proliferative and anti-adhesive effect in ovarian cancer cells: an in vitro studies

Morin inhibits Listeria monocytogenes virulence in vivo and in vitro by targeting listeriolysin O and inflammation

Self-assembled and pH-responsive polymeric nanomicelles impart effective delivery of paclitaxel to cancer cells

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