Designing of chalcone functionalized 1,2,3-triazole allied bis-organosilanes as potent antioxidants and optical sensor for recognition of Sn2+ and Hg2+ ions

Singh, Gurjaspreet; Sushma, .; Singh, Akshpreeet; Priyanka, .; Chowdhary, Kavita; Singh, Jandeep; Esteban, María Ángeles; Espinosa, Cristóbal; González-Silvera, Daniel

doi:10.1016/j.jorganchem.2021.122049

Cited by 8 publications

(1 citation statement)

References 29 publications

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“…The bis-chalcone-1,2,3-triazole-organosilane 79 ( Figure 27 ) was found to display antioxidant activity in a total antioxidant activity (TAA) assay, through the ability to reduce the radical cation of ABTS, determined by the decoloration of ABTS •+ [ 118 ]. This compound, obtained by CuAAC in excellent yield in the presence of [CuBr(PPh 3 ) 3 ]/ TEA-THF system under inert atmosphere, showed a better antioxidant profile when compared with the acetylenic chalcone precursor and the positive control ascorbic acid [ 118 ].…”

Section: Other Activitiesmentioning

confidence: 99%

Recent Advances in Bioactive Flavonoid Hybrids Linked by 1,2,3-Triazole Ring Obtained by Click Chemistry

et al. 2021

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As a result of the biological activities of natural flavonoids, several synthetic strategies aiming to obtain analogues with improved potency and/or pharmacokinetic profile have been developed. Since the triazole ring has been associated with several biological activities and metabolic stability, hybridization with a 1,2,3-triazole ring has been increasingly reported over the last years. The feasible synthesis through copper (I) catalyzed azide-alkyne cycloaddition (CuAAC) has allowed the accomplishment of several hybrids. Since 2017, almost 700 flavonoid hybrids conjugated with 1,2,3-triazole, including chalcones, flavones, flavanones and flavonols, among others, with antitumor, antimicrobial, antidiabetic, neuroprotective, anti-inflammatory, antioxidant, and antifouling activity have been reported. This review compiles the biological activities recently described for these hybrids, highlighting the mechanism of action and structure–activity relationship (SAR) studies.

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Section: Other Activitiesmentioning

confidence: 99%