Designing functional hyaluronic acid-based hydrogels for cartilage tissue engineering

Wang, Min; Deng, Zexing; Guo, Yi; Xu, Peng

doi:10.1016/j.mtbio.2022.100495

Cited by 26 publications

(21 citation statements)

References 179 publications

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“…In consideration of irregular surfaces of cartilage defects, injectable hydrogels have offered great advantages for the application of cartilage tissue engineering owing to their adapted shape and in situ cross-linking capability. , To date, substantial effort has been applied to construct hydrogel scaffolds by developing various functional cross-linkable polymers. Biodegradable hyaluronic acid (HA), a major component in cartilage tissue, has been extensively modified to fabricate cartilage scaffolds. − Alternatively, a biodegradable polyphosphate has become a prominent synthetic polymer due to its controlled synthesis, versatile functionality, tunable structures, and tailorable properties. , …”

Section: Introductionmentioning

confidence: 99%

Injectable and Degradable POSS–Polyphosphate–Polysaccharide Hybrid Hydrogel Scaffold for Cartilage Regeneration

Cui

Yang

Hong

et al. 2023

ACS Appl. Mater. Interfaces

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The limited self-repair capacity of articular cartilage has motivated the development of stem cell therapy based on artificial scaffolds that mimic the extracellular matrix (ECM) of cartilage tissue. In view of the specificity of articular cartilage, desirable tissue adhesiveness and stable mechanical properties under cyclic mechanical loads are critical for cartilage scaffolds. Herein, we developed an injectable and degradable organic−inorganic hybrid hydrogel as a cartilage scaffold based on polyhedral oligomeric silsesquioxane (POSS)-cored polyphosphate and polysaccharide. Specifically, acrylated 8-arm star-shaped POSS-poly(ethyl ethylene phosphate) (POSS-8PEEP-AC) was synthesized and crosslinked with thiolated hyaluronic acid (HA-SH) to form a degradable POSS-PEEP/HA hydrogel. Incorporation of POSS in the hydrogel increased the mechanical properties. The POSS-PEEP/HA hydrogel showed enzymatic biodegradability and favorable biocompatibility, supporting the growth and differentiation of human mesenchymal stem cells (hMSCs). The chondrogenic differentiation of encapsulated hMSCs was promoted by loading transforming growth factor-β 3 (TGF-β 3 ) in the hydrogel. In addition, the injectable POSS-PEEP/HA hydrogel was capable of adhering to rat cartilage tissue and resisting cyclic compression. Furthermore, in vivo results revealed that the transplanted hMSCs encapsulated in the POSS-PEEP/HA hydrogel scaffold significantly improved cartilage regeneration in rats, while the conjugation of TGF-β 3 achieved a better therapeutic effect. The present work demonstrated the potential of the injectable, biodegradable, and mechanically enhanced POSS-PEEP/HA hybrid hydrogel as a scaffold biomaterial for cartilage regeneration.

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Section: Introductionmentioning

confidence: 99%

Injectable and Degradable POSS–Polyphosphate–Polysaccharide Hybrid Hydrogel Scaffold for Cartilage Regeneration

Cui

Yang

Hong

et al. 2023

ACS Appl. Mater. Interfaces

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show abstract

Section: Introductionmentioning

confidence: 99%

“…These hydrogels have a certain immune regulation effect; in addition, they can provide mechanical support and a favorable microenvironment for chondrocytes or stem cells, which facilitate cartilage regeneration. [4][5][6] Chemical components of hydrogels play an active role in regulating inflammatory response and cartilage repair. [6][7][8][9][10] HA can interact with cell surface receptors (CD44, RHAMM, and ICAM-1) to modulate inflammation and cartilage repair.…”

Section: Introductionmentioning

confidence: 99%

“…[4][5][6] Chemical components of hydrogels play an active role in regulating inflammatory response and cartilage repair. [6][7][8][9][10] HA can interact with cell surface receptors (CD44, RHAMM, and ICAM-1) to modulate inflammation and cartilage repair. 6,7 The structural domain in Col I contains a large number of integrinbinding motifs facilitating cell-matrix interactions.…”

Section: Introductionmentioning

confidence: 99%

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Components and physical properties of hydrogels modulate inflammatory response and cartilage repair

Gao,

Dai,

et al. 2023

J. Mater. Chem. B

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“…5 However, HA degrades rapidly and exhibits poor biomechanical properties. 6 To increase the effect of HA as a viscosupplement, novel hybrid hydrogel strategies have been developed by forming complexes with various organics and using biopolymers. 7−10 In recent years, the addition of nanoparticles to hydrogels has attracted the attention of researchers because of their ability to interact with polymer functional groups.…”

Section: Introductionmentioning

confidence: 99%

Boron Nitride’s Morphological Role in the Design of Injectable Hyaluronic Acid Based Hybrid Artificial Synovial Fluid

Goncu,

2023

ACS Biomater. Sci. Eng.

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The treatment process of osteoarthritis (OA) is challenging as it affects not only cartilage but also subchondral bone, ligament attachment capsules, synovium, and surrounding muscle tissue. Therefore, the search for preventive treatment or methods to slow the onset of the condition. Hexagonal boron nitride (hBN) has a graphite-like lamellar structure and is thought to facilitate cartilage movement for biomedical applications, just like in bearing systems. Hyaluronic acid (HA) is one of the natural polymers that can be used to transport boron nitride and maintain its presence in joints for a long time. In this study, hybrid hydrogels were formulated by using boron nitride nanoparticles and nanosheets. The rheological properties of the hydrogels were evaluated according to the structural differences of hBN. Characterizations have shown that hybrid hydrogels can be produced in injectable form, and the rheological properties are strongly related to the structural properties of the added particle. It has been determined that hBN added to the hydrogel structure reduces the dynamic viscosity of the zero-shear point and the deformation rate of the hydrogel and also changes the viscoelastic properties of the hydrogel depending on boron nitride’s structural differences. The suggested mechanism is the hybrid hydrogel that exhibits lower viscosity as the layers detach from each other or disperses the agglomerates under applied shear stress. hBN, which has been proposed as a new strategy for joint injections, is thought to be a promising candidate for the treatment of OA due to its lamellar structures.

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Designing functional hyaluronic acid-based hydrogels for cartilage tissue engineering

Cited by 26 publications

References 179 publications

Injectable and Degradable POSS–Polyphosphate–Polysaccharide Hybrid Hydrogel Scaffold for Cartilage Regeneration

Injectable and Degradable POSS–Polyphosphate–Polysaccharide Hybrid Hydrogel Scaffold for Cartilage Regeneration

Components and physical properties of hydrogels modulate inflammatory response and cartilage repair

Boron Nitride’s Morphological Role in the Design of Injectable Hyaluronic Acid Based Hybrid Artificial Synovial Fluid

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