Components and physical properties of hydrogels modulate inflammatory response and cartilage repair

Gao, Yongli; Dai, Wenling; Li, Shikui; Zhao, Xingchen; Wang, Jing; Fu, Weili; Guo, Likun; Fan, Yujiang; Zhang, Xingdong

doi:10.1039/d3tb01917a

Cited by 3 publications

(2 citation statements)

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“…Compared to dendrimers, HD does not have significant toxicological concerns associated with cationic dendritic polymers, rapid systemic clearance, and other drawbacks . In contrast to small molecule HA that may trigger inflammation, HD hydrogel exhibits excellent biocompatibility and does not induce additional inflammatory responses . While hyaluronic acid–based gels break down quickly in the body due to hyaluronidase, the HD hydrogel can be adjusted for biodegradability, mechanical strength, and rheological properties by modifying the ratio of PEGDE and HD.…”

Section: Results and Discussionmentioning

confidence: 99%

“…81 In contrast to small molecule HA that may trigger inflammation, HD hydrogel exhibits excellent biocompatibility and does not induce additional inflammatory responses. 82 While hyaluronic acid−based gels break down quickly in the body due to hyaluronidase, the HD hydrogel can be adjusted for biodegradability, mechanical strength, and rheological properties by modifying the ratio of PEGDE and HD. This allows it to effectively cover the critical period of postoperative adhesion formation, achieve better efficacy, and facilitate clinical use, including laparoscopy.…”

Section: Potential Mechanism Of Hd-based Cross-linked Hydrogels In Pr...mentioning

confidence: 99%

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Hemoadhican-Based Bioabsorbable Hydrogel for Preventing Postoperative Adhesions

Lu,

Wang,

Kong

et al. 2024

ACS Appl. Mater. Interfaces

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Postoperative peritoneal adhesions are a prevalent clinical issue following abdominal and pelvic surgery, frequently resulting in heightened personal and societal health burdens. Traditional biomedical barriers offer limited benefits because of practical challenges for doctors and their incompatibility with laparoscopic surgery. Hydrogel materials, represented by hyaluronic acid gels, are receiving increasing attention. However, existing antiadhesive gels still have limited effectiveness or carry the risk of complications in clinical applications. Herein, we developed a novel hydrogel using polysaccharide hemoadhican (HD) as the base material and polyethylene glycol diglycidyl ether (PEGDE) as the cross-linking agent. The HD hydrogels exhibit appropriate mechanical properties, injectability, and excellent cytocompatibility. We demonstrate resistance to protein adsorption and L929 fibroblast cell adhesion to the HD hydrogel. The biodegradability and efficacy against peritoneal adhesion are further evaluated in C57BL/6 mice. Our results suggest a potential strategy for antipostoperative tissue adhesion barrier biomaterials.

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Section: Results and Discussionmentioning

confidence: 99%

Section: Potential Mechanism Of Hd-based Cross-linked Hydrogels In Pr...mentioning

confidence: 99%