Designing electrochemical interfaces based on nanohybrids of avidin functionalized-carbon nanotubes and ruthenium nanoparticles as peroxidase-like nanozyme with supramolecular recognition properties for site-specific anchoring of biotinylated residues

Gallay, Pablo; Eguílaz, Marcos; Rivas, Gustavo A.

doi:10.1016/j.bios.2019.111764

Cited by 46 publications

(34 citation statements)

References 45 publications

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“…As mentioned above, metal-and metal oxide-based nanozymes normally come along with unique physicochemical properties including high surface-to-volume ratio, enzymatic activity and good biocompatibility. These capabilities endow them with promising applications in target substances detection following the extensive exploration of biosensing schemes [279].…”

Section: Applications In Analytical Fieldmentioning

confidence: 99%

A Review on Metal- and Metal Oxide-Based Nanozymes: Properties, Mechanisms, and Applications

et al. 2021

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Since the ferromagnetic (Fe3O4) nanoparticles were firstly reported to exert enzyme-like activity in 2007, extensive research progress in nanozymes has been made with deep investigation of diverse nanozymes and rapid development of related nanotechnologies. As promising alternatives for natural enzymes, nanozymes have broadened the way toward clinical medicine, food safety, environmental monitoring, and chemical production. The past decade has witnessed the rapid development of metal- and metal oxide-based nanozymes owing to their remarkable physicochemical properties in parallel with low cost, high stability, and easy storage. It is widely known that the deep study of catalytic activities and mechanism sheds significant influence on the applications of nanozymes. This review digs into the characteristics and intrinsic properties of metal- and metal oxide-based nanozymes, especially emphasizing their catalytic mechanism and recent applications in biological analysis, relieving inflammation, antibacterial, and cancer therapy. We also conclude the present challenges and provide insights into the future research of nanozymes constituted of metal and metal oxide nanomaterials.

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Section: Applications In Analytical Fieldmentioning

confidence: 99%

A Review on Metal- and Metal Oxide-Based Nanozymes: Properties, Mechanisms, and Applications

et al. 2021

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“…Many of these materials have the capacity to give high sensitivity in electrochemical detection, while supramolecular systems can be integrated into the sensor design to give enhanced selectivity and sensitivity for the target analyte. Molecular recognition systems can vary from enzymes, antibodies, proteins [9], to aptamers (singlestranded DNA or RNA) [10], and to supramolecular molecules, such as cyclodextrins [11], calixarenes [12], cucurbiturils [13], crown ethers [14], and pillararenes [15].…”

Section: Introductionmentioning

confidence: 99%

Cyclodextrins as Supramolecular Recognition Systems: Applications in the Fabrication of Electrochemical Sensors

et al. 2021

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Supramolecular chemistry, although focused mainly on noncovalent intermolecular and intramolecular interactions, which are considerably weaker than covalent interactions, can be employed to fabricate sensors with a remarkable affinity for a target analyte. In this review the development of cyclodextrin-based electrochemical sensors is described and discussed. Following a short introduction to the general properties of cyclodextrins and their ability to form inclusion complexes, the cyclodextrin-based sensors are introduced. This includes the combination of cyclodextrins with reduced graphene oxide, carbon nanotubes, conducting polymers, enzymes and aptamers, and electropolymerized cyclodextrin films. The applications of these materials as chiral recognition agents and biosensors and in the electrochemical detection of environmental contaminants, biomolecules and amino acids, drugs and flavonoids are reviewed and compared. Based on the papers reviewed, it is clear that cyclodextrins are promising molecular recognition agents in the creation of electrochemical sensors, chiral sensors, and biosensors. Moreover, they have been combined with a host of materials to enhance the detection of the target analytes. Nevertheless, challenges remain, including the development of more robust methods for the integration of cyclodextrins into the sensing unit.

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“…(c) Schematic illustration of the enzymatic glucose biosensor fabrication [12]: (i) preparation of the long conducting enzyme-loading hybrid nanocomposite GOx@PAVE-CNTs via one-step co-assembly; (ii) preparation process of glucose biosensor via direct electrophoretic deposition (EPD) of GOx@PAVE-CNTs onto glassy carbon electrode (GCE) surface and subsequent photo-cross-linking. (d) Schematic display of the steps involved in the preparation of the GCE/MWCNTs-Av/RuNPs/biot-GOx biosensor [54].…”

Section: Carbon Nanotubes (Cnts) and Their Hybrid-based Glucose Biosementioning

confidence: 99%

“…Recently, Rivas’s group [ 54 ] have demonstrated an original supramolecular architecture based on a rationally-designed nanohybrid combination of MWCNTs and ruthenium nanoparticles ( Figure 5 d). For this construction they took advantage of avidin which is a biotin-binding protein.…”

Section: Enzymatic and Non-enzymatic Electrochemical Biosensorsmentioning

confidence: 99%

A Critical Review of Electrochemical Glucose Sensing: Evolution of Biosensor Platforms Based on Advanced Nanosystems

Juska

Pemble

2020

Sensors

135

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The research field of glucose biosensing has shown remarkable growth and development since the first reported enzyme electrode in 1962. Extensive research on various immobilization methods and the improvement of electron transfer efficiency between the enzyme and the electrode have led to the development of various sensing platforms that have been constantly evolving with the invention of advanced nanostructures and their nano-composites. Examples of such nanomaterials or composites include gold nanoparticles, carbon nanotubes, carbon/graphene quantum dots and chitosan hydrogel composites, all of which have been exploited due to their contributions as components of a biosensor either for improving the immobilization process or for their electrocatalytic activity towards glucose. This review aims to summarize the evolution of the biosensing aspect of these glucose sensors in terms of the various generations and recent trends based on the use of applied nanostructures for glucose detection in the presence and absence of the enzyme. We describe the history of these biosensors based on commercialized systems, improvements in the understanding of the surface science for enhanced electron transfer, the various sensing platforms developed in the presence of the nanomaterials and their performances.

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Designing electrochemical interfaces based on nanohybrids of avidin functionalized-carbon nanotubes and ruthenium nanoparticles as peroxidase-like nanozyme with supramolecular recognition properties for site-specific anchoring of biotinylated residues

Cited by 46 publications

References 45 publications

A Review on Metal- and Metal Oxide-Based Nanozymes: Properties, Mechanisms, and Applications

A Review on Metal- and Metal Oxide-Based Nanozymes: Properties, Mechanisms, and Applications

Cyclodextrins as Supramolecular Recognition Systems: Applications in the Fabrication of Electrochemical Sensors

A Critical Review of Electrochemical Glucose Sensing: Evolution of Biosensor Platforms Based on Advanced Nanosystems

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