Designer fibers from 2D to 3D – Simultaneous and controlled engineering of morphology, shape and size

Yao, Zhi Cheng; Zhang, Chunchen; Ahmad, Zeeshan; Huang, Jie; Li, Jing Song; Chang, Ming Wei

doi:10.1016/j.cej.2017.10.033

Cited by 48 publications

(41 citation statements)

References 54 publications

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“…Thus, in this study the outer solvent was used to prevent any clinging of semi-solid CA to the spinneret, preventing blocking of the needles and ensuring a stable and continuous electrospinning process. The outer solvent should also help the electrical forces to draw the inner and middle fluids evenly during the solvent exhaustion process (Yao, et al, 2018). These two effects of the outer solvent are combined synergistially to ensure the formation of high-quality nanofibers regardless of their composition (either monolithic F1 systems or core-shell hybrids in the case of F2 to F4).…”

Section: Morphological Characteristics and Inner Structures Of The Prmentioning

confidence: 99%

Tunable drug release from nanofibers coated with blank cellulose acetate layers fabricated using tri-axial electrospinning

Yang

et al. 2019

Carbohydrate Polymers

138

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In this study, novel core-shell nanostructures were fabricated through a modified triaxial electrospinning process. These comprised a drug-protein nanocomposite coated with a thin cellulose acetate (CA) shell. They were generated through the simultaneous treatment of an outer solvent, an unelectrospinnable middle fluid, and an electrospinnable core solution in triaxial electrospinning. SEM and TEM results revealed that the core-shell nanofibers had linear and cylindrical morphologies with a diameter from , and distinct core-shell structures with a shell thickness from 1.8 to 11.6 nm. The presence of a CA coating eliminated the initial burst release of ibuprofen seen from a monolithic drug-protein composite, and allowed us to precisely manipulate the drug release (for a 90% percentage) over a time period from 23.5 to 43.9 h in a tunable manner. Mathematical relationships between the processing conditions, the nanostructures produced, and their functional performance were elucidated.

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Section: Morphological Characteristics and Inner Structures Of The Prmentioning

confidence: 99%

Tunable drug release from nanofibers coated with blank cellulose acetate layers fabricated using tri-axial electrospinning

Yang

et al. 2019

Carbohydrate Polymers

138

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“…Furthermore, they have been described to strongly interact with natural polyphenols through hydrophobic interactions and hydrogen bonding (Jakobek, 2015;Siebert, Troukhanova, & Lynn, 1996), implying that the stability of electrospun protein fibers could be further improved by the addition of polyphenols as natural crosslinkers for proteins (Anvari & Chung, 2016). In particular, zein and gelatin are two proteins whose ability to form electrospun fibers has been already demonstrated (Lu et al, 2015;Yao et al, 2018). In addition, both proteins have previously shown their potential to enhance the stability of sensitive bioactive ingredients encapsulated within them through electrohydrodynamic processing (Gómez-Mascaraque et al, 2015;Gómez-Mascaraque, Perez-Masiá, González-Barrio, Periago, & López-Rubio, 2017).…”

Section: Some Of the Advantages Of Electrohydrodynamic Processing As mentioning

confidence: 99%

Electrospun curcumin-loaded protein nanofiber mats as active/bioactive coatings for food packaging applications

et al. 2019

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In this study, curcumin was encapsulated within electrospun protein (i.e. gelatin and zein) 15 fibers to generate bioactive coatings for food packaging. Additionally, a green tea extract (GTE) was also incorporated within the formulations to evaluate its impact on the stability, protective ability, and release properties of the curcumin-loaded fibers. Due to the poor solubility of curcumin in aqueous media, a strategy based on its incorporation through liposomes was developed, allowing to successfully incorporating curcumin into gelatin fibers. Very high encapsulation efficiencies were attained for both zein and gelatin, with the former showing an enhanced protection effect and a more limited and slower release of the curcumin in hydrophobic food simulants. The addition of GTE resulted in strong interactions being established with the proteins and, in the particular case of gelatin, it improved the protective effect and slowed down the curcumin release from the fibers, although it did not prevent their collapse in water. The results showed that while the developed gelatin coatings showed a promising release behavior in contact with fatty food simulants, zein-based coatings would be more adequate for packaging of high water content food products.

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“…More recently, researchers have developed two-fluid side-by-side and coaxial electrospinning processes (resulting in Janus or core/shell fibers) [10][11][12][13][14][15][16], three-fluid triaxial electrospinning, and other more complicated experiments [17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Tunable zero-order drug delivery systems created by modified triaxial electrospinning

Liu

Yang

et al. 2019

Chemical Engineering Journal

136

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ucture, and in turn its functional performance, is of crucial importance for potential applications. In this study, a new modified triaxial electrospinning process was successfully developed to allow us to precisely tune drug release from nanoscale formulations. In this process, we used two un-electrospinnable liquids as the outer and middle working fluids, with only the core solution being individually electrospinnable into fibers. The outer liquid comprised a mixture of solvents, while the middle fluid was a dilute solution of cellulose acetate (CA). The core fluid was an electrospinnable co-dissolving solution of ferulic acid (FA) and gliadin. By processing these in triaxial electrospinning, we were able to create FA-gliadin fibers coated with a thin but even and continuous coating of CA. The thickness of the CA coating could be precisely varied by adjusting the flow rate of the middle working fluid. The resultant nanofibers have linear and cylindrical morphologies with clear core-shell structures. X-ray diffraction and IR spectroscopy data verified that the fibers comprised amorphous solid dispersions, with intermolecular interactions existing between FA and gliadin. The CA coating eliminated the initial burst release seen with uncoated FA-gliadin fibers, and also led to close to zero-order release profiles which could be incrementally adjusted by varying the thickness of the coating. New process-nanostructure-performance relationships are therefore revealed, and the advanced triaxial electrospinning approach reported in this work has great potential for developing new kinds of functional nanomaterials.

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Designer fibers from 2D to 3D – Simultaneous and controlled engineering of morphology, shape and size

Cited by 48 publications

References 54 publications

Tunable drug release from nanofibers coated with blank cellulose acetate layers fabricated using tri-axial electrospinning

Tunable drug release from nanofibers coated with blank cellulose acetate layers fabricated using tri-axial electrospinning

Electrospun curcumin-loaded protein nanofiber mats as active/bioactive coatings for food packaging applications

Tunable zero-order drug delivery systems created by modified triaxial electrospinning

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