Tunable drug release from nanofibers coated with blank cellulose acetate layers fabricated using tri-axial electrospinning

Abstract

In this study, novel core-shell nanostructures were fabricated through a modified triaxial electrospinning process. These comprised a drug-protein nanocomposite coated with a thin cellulose acetate (CA) shell. They were generated through the simultaneous treatment of an outer solvent, an unelectrospinnable middle fluid, and an electrospinnable core solution in triaxial electrospinning. SEM and TEM results revealed that the core-shell nanofibers had linear and cylindrical morphologies with a diameter from , and distinct core-shell structures with a shell thickness from 1.8 to 11.6 nm. The presence of a CA coating eliminated the initial burst release of ibuprofen seen from a monolithic drug-protein composite, and allowed us to precisely manipulate the drug release (for a 90% percentage) over a time period from 23.5 to 43.9 h in a tunable manner. Mathematical relationships between the processing conditions, the nanostructures produced, and their functional performance were elucidated.

Gallic Acid‐Loaded Zein Nanoparticles by Electrospraying Process

“…Although EHDA processes (including e‐jet printing, electrospraying, and electrospinning) are fast developing to the multiple‐fluids ones, such as coaxial (Hai et al., ; Yu et al., ), triaxial (Liu et al., ; Yang et al., ), their microformation mechanisms are still unclear (Yang, Zhang, Liu, Wang, & Yu, ; Yu, Li, Williams, & Zhao, ). Thus, on one hand, the single‐fluid electrospraying and electrospinning are still the mainstreams of these fabrication methods.…”

Recent Developments in Nanofiber Fabrication and Modification for Bone Tissue Engineering

“…The processes after that are similar to a conventional electrospinning, in which a collector is used to carry fibers. Co-axial electrospinning permits various materials, including polymers [46,47], oligomers [48], inorganic compounds [37], proteins [47], and biomolecules [41], to be immobilized into the core component of the core-shell nanofibers. Due to the functions of the core component, the core-shell nanofiber has more beneficial properties for bone tissue engineering.…”

“…Core-shell structure nanofibers can also be made by three channel arrays of spinnerets. Yang et al developed the modified tri-axial electrospinning method to prevent clogging in electrospinning [41]. Polyvinyl chloride (PVC) is selected as an antistatic coating material of spinnerets.…”

“…Polyvinyl chloride (PVC) is selected as an antistatic coating material of spinnerets. The production of core-shell structures could be achieved by implementing a modified tri-axial process; in contrast, such structures are difficult to obtain from conventional co-axial electrospinning because a lubricating shell solvent is needed [41,51]. Increasing the number of spinnerets helps build up the core-shell structure, allowing the development of a drug delivery system for bone tissue engineering.…”

Elastomagnetic nanofiber wires by magnetic field assisted electrospinning

“…In the recent years, innovative electrospun nanocomposites have been produced for photocatalytic, conductive, mechanical and biomedical applications [1][2][3][4][5]. At the same time, several improvements of the standard electrospinning process have been performed to achieve specific objectives, such as tri-axial processing [6], temperature control [7,8], double-switching voltage [9], stepped airflow coupled to friction twisting [10] and bubble electrospinning [11]. Among the various techniques used to direct the electrospinning process to particular purposes, an important role was played by the Magnetic Field Assisted Electrospinning (MFAE) which was directed to the fabrication of polymeric fibers loaded with magnetic particles.…”