“…Also, functionalized quinazolines possess diverse biological, and pharmaceutical activities as antibacterial [14], antioxidant [15], antiviral [16], anti-HIV [17], anticonvulsant [18], anti-obesity [19], antituberculosis [20], inflammatory [21], analgesic [22], anti-diabetes [23], anti-psychotic [24], anticytotoxin [25], and anti-hypertension [26], and insecticidal [27]. In addition, substituted 1,3,4thiadiazole derivatives have received significant attention during the last years, and have been investigated increasingly due to their various therapeutic and industrial applications, the biological activities of 1,3,4-thiadiazole derivatives is supposed due to the presence of =N−C−S− moiety [28,29].…”