A green synthesis of pyrimido[4,5-b]quinolines and pyrido[2,3-d]pyrimidines via a mechanochemical approach

Abstract

A cost-effective and competent approach has been established for the synthesis of N-heterocyclic pyrimido [4,5-b] quinolines and pyrido [2,3-d] pyrimidines via multicomponent reaction of 1,3 diketones (dimedone, barbituric acid and...

An Effective and Environmentally Friendly One-pot Multicomponent Approach for the Synthesis of spiroannulated hybrid molecules with Preferred Substructures using Indium Triflate as an efficient and Reusable Catalyst

“…As a result, widespread resources were dedicated towards synthetic modi cation in the synthesis of these compounds of uracils. 25 Pyrido [2,3-d] pyrimidine framework exhibits a new variety of biological actions like tyrosine kinase activity, calcium channel antagonist activity, antiin ammatory activity, analgesic activity, antiaggressive activity, antifolate activity, antileishmanial activity, antiviral, 26 diuretic, 27 anticonvulsive, 28 antipyretic, 29 cardiotonic, 30 antitumoral, 31 antihistaminic, 32 antibacteria 33 bronchodilator, 34 Fig. 2 illustrates some bioactive pyridopyrimidines.…”