Abstract:Nineteen N-benzyl linoleamide analogues (macamide from Tropaeolum tuberosum) were synthesised, modifying the molecular structure (benzyl position, aromatic ring and carbonyl group). The structures were confirmed using nuclear magnetic resonance and mass spectrometry techniques. Cell viability and anti-inflammatory activity of these compounds were evaluated in three brain cell lines (C8-D1 A, Neuro-2a, and EOC 13.31). Regarding the effect on NF-kB, several analogues had better inhibition potential than their na… Show more
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