Antioxidant and antiproliferative potential of ethanolic extracts from Moringa oleifera, Tropaeolum tuberosum and Annona cherimola in colorrectal cancer cells

Fuel, Marco; Mesas, Cristina; Martínez, R.; Ortíz, Raúl; Quiñonero, Francisco; Prados, José Luis Paniza; Porres, Jesús M.; Melguizo, Consolación

doi:10.1016/j.biopha.2021.112248

Cited by 16 publications

(15 citation statements)

References 79 publications

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“…Within the group of phenolic compounds, flavonoids (flavones, flavanones, and flavanols), phenolic acids, and phenylpropanoids were particularly present. In addition acetogenins were identified, in the A. cherimola ethanolic extract (Fuel et al, 2021).…”

Section: Key Metabolites In Annona's Different Partsmentioning

confidence: 99%

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Botanical, genetic, phytochemical and pharmaceutical aspects of Annona cherimola Mill

Perrone

Yousefi

Alireza³

et al. 2022

Scientia Horticulturae

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Section: Key Metabolites In Annona's Different Partsmentioning

confidence: 99%

“…Therefore, although in vivo testing will be necessary, ethanolic extracts from M. oleifera, T. tuberosum, and A. cherimola are becoming new therapeutic options. These extracts could be used either alone or in combination with other antitumor agents, for the prevention and treatment of CRC (Fuel et al, 2021).…”

Section: Anti-cancerogenic Actionmentioning

confidence: 99%

Botanical, genetic, phytochemical and pharmaceutical aspects of Annona cherimola Mill

Perrone

Yousefi

Alireza³

et al. 2022

Scientia Horticulturae

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“…Compound #1, yielded a parent ion with an accurate mass of 478.1695 and m/z ratio at 523.1677, which corresponded with [M + HCOO-]-, i.e., the formate adduct of kelampayoside A. The identity of phenolic apioglucoside was established based on the obtained MS data and literature report 40 and has been previously described as a strong radical scavenging agent. Other phenolic glycosides observed in AGPE include bufotenine O-glucoside 41 , verbasoside or decaffeoylverbascoside (a phenylpropanoid glycoside) with major peak at m/z 461, corresponding to the deprotonated pseudomolecular ion [M-H]- 42 ; trans-p-Coumaric acid 4-glucoside, Quercetin 3-[p-coumaroyl-(- > 6)-glucosyl-(1- > 2)-glucosyl-(1- > 2)-glucoside] (a flavonoid-o-3-glycoside); Glucoliquiritin apioside (a flavonoid-7-o-glycoside) and the lignan glycoside, 8-Acetoxypinoresinol 4-glucoside.…”

Section: Resultsmentioning

confidence: 90%

Synthesis of biocompatible Konjac glucomannan stabilized silver nanoparticles, with Asystasia gangetica phenolic extract for colorimetric detection of mercury (II) ion

Jayeoye

Eze

Olatunji

et al. 2022

Sci Rep

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Herein, the synthesis of a biocompatible silver nanoparticles (AgNPs), for colorimetric detection of toxic mercury (II) ion (Hg2+), is reported. Phenolic-rich fraction of Asystasia gangetica leaf was extracted and used as a reductant of silver salt, all within the hydrophilic konjac glucomannan (KgM) solution as stabilizer, at room temperature (RT). The bioactive components of Asystasia gangetica phenolic extract (AGPE), as elucidated with a (UHPLC-MS-QTOF-MS), revealed plethora of phenolic compounds, which can facilitate the reduction of silver salt at ambient conditions. Sparkling yellow colloidal solution of KgM-AgNPs was realized within 1 h, at RT, having a UV–vis maximum at 420 nm. KgM-AgNPs was characterized using UV–vis, Raman and (FTIR), TEM, SEM, EDS, XRD, TGA/DTG. TEM and FESEM images showed that KgM-AgNPs were spherical, with particle size distribution around 10–15 nm from TEM. The KgM-AgNPs biocompatibility was investigated on mouse L929 fibrobroblast and rat erythrocytes, without any harmful damages on the tested cells. In aqueous environment, KgM-AgNPs demonstrated good detection capacity toward Hg2+, in a Hg2+ concentration dependent fashion, within 3 min. Absorbance ratios (A360/A408) was linear with Hg2+ concentrations from 0.010–10.0 to 10.0–60.0 µM, with an estimated (LOD) of 3.25 nM. The probe was applied in lake water sample, with satisfactory accuracy.

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“…Cytotoxic activity has been studied in fruit, leaves, root, and stem bark extracts or isolated acetogenins of some Annona species ( Table 4 ). Annonacin at a very low dose (extracted from A. muricata leaves) decreased the induced-tumors on mice [ 147 , 148 ]; moreover, acetogenins have a potent cytotoxicity against many cancer cell lines (DU-145, A-549, MCF-7, HT-29, A-498, PC-3, HL60, HCT, Caco-2, and HepG-2) [ 88 , 96 , 119 , 137 , 143 , 149 , 150 , 151 , 152 ]. The mechanism of action of acetogenins on cancer cell lines or in vivo cancer models is attributed to inhibition mitochondrial complex I (ubiquinone-linked NADH oxidase) to present in cell membranes; the ATP decrease cause apoptosis [ 123 ].…”

Section: Agronomic Knowledgementioning

confidence: 99%

Current Situation and Perspectives of Fruit Annonaceae in Mexico: Biological and Agronomic Importance and Bioactive Properties

Fuentes

Montalvo‐González

Magaña

et al. 2021

Plants

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The Annonaceae family is one of the oldest angiosperms. The genus Annona is the one with the most species and, together with Asimina, the only ones that contain edible fruits. In the last 10 years, interest in these fruit species has increased, mainly due to their nutritional properties and their application in the treatment of human diseases. Mexico is the center of origin for most of them. However, at present much of the basic agronomic information, postharvest handling of the fruits, and their potential as new crops for areas with poor soils in organic matter or semi-dry climates is unknown. It is considered that these custard apple species may be an option to change towards instead of crops that have lost profitability and sustainability. A review of the current state of knowledge in different areas of the species A. muricata, A. macroprophyllata, A. reticulata, A. squamosa, and A. cherimola was carried out and to focus research efforts on the topics of greatest interest and on those where is required to achieve a sustainable production and use of these resources in Mexico. However, knowledge about the cultivation and potential uses of these species is needed to increase their commercialization; the integration of interdisciplinary and interinstitutional groups is required.

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Antioxidant and antiproliferative potential of ethanolic extracts from Moringa oleifera, Tropaeolum tuberosum and Annona cherimola in colorrectal cancer cells

Cited by 16 publications

References 79 publications

Botanical, genetic, phytochemical and pharmaceutical aspects of Annona cherimola Mill

Botanical, genetic, phytochemical and pharmaceutical aspects of Annona cherimola Mill

Synthesis of biocompatible Konjac glucomannan stabilized silver nanoparticles, with Asystasia gangetica phenolic extract for colorimetric detection of mercury (II) ion

Current Situation and Perspectives of Fruit Annonaceae in Mexico: Biological and Agronomic Importance and Bioactive Properties

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