Design, synthesis and anticancer activities of hybrids of indole and barbituric acids—Identification of highly promising leads

Photochemical synthesis and anticancer activity of barbituric acid, thiobarbituric acid, thiosemicarbazide, and isoniazid linked to 2-phenyl indole derivatives

“…Recent literature survey reveals that antitumor activities of indole derivatives [9][10][11] possessed a unique photoresponsive activity [12] used in light-emitting electrochemical cells [13], solid-state lasers, fluorescent labels, etc. 2-Phenyl-1H-indole-3-carbaldehyde derivatives inhibited the growth of MDA-MB-231 and MCF7 breast cancer cells by combining indole and barbituric acid, and new hybrid molecules were synthesized and evaluated for anticancer activity [14][15][16][17][18]. Fan Zhang et al synthesized and evaluated in vitro antitumor activity of 2-amino-3-cyano-6-(1H-indole-3-yl)-4-phenylpyridine derivatives.…”

Synthesis of Novel Pyrazolylmethylene-Pyrimidine Heterocycles: Potential Synthons for Hybrid Β-Lactams

“…Pyrazole and barbituric acid based hybrid systems constitute an elite category of heterocycles due to their unique structural features along with their wide range of pharmacological activities such as antitumor [2], antimicrobial [4], anticancer [6] etc. Pyrazole and its derivatives have remained as an active area of research due to its extensive applications in agrochemical and pharmaceutical industries [7].…”

Synthesis of Substituted 2-Phenyl-1H-indoles and their Fungicidal Activity

“…These compounds are known to possess variety of bioactivities like antifungal, anticancer, antiviral and antimicrobial [1][2][3][4] etc. Indoles, also known as benzpyrrole are aromatic nitrogen heterocycles of prime importance containing fused benzene and pyrrole rings.…”