Design, synthesis, and antibacterial studies of potent pyrazolinyltriazoles

Archana, Sivasubramaniyan; Raja, R.; Dinesh, Murugan; Arul, P.; Ponnuswamy, Alagusundaram; Kalaiselvi, P.; Chellammal, S.; Subramanian, G.

doi:10.1007/s11164-016-2774-6

Cited by 13 publications

(4 citation statements)

References 18 publications

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“…It has previously been shown that hybrid molecules containing two or more heterocyclic fragments in one structure exhibit synergistic or additive pharmacological activity compared to compounds with each individual pharmacophore [ 35 , 36 ]. Thus, in bioactive molecules, it is possible to change the pKa, to develop conformational hindrances and the regulation of the hydrophilic-hydrophobic balance, and to increase lipophilicity, and all these parameters can be varied both individually and in various combinations [ 37 , 38 , 39 ].…”

Section: Introductionmentioning

confidence: 99%

Biologically Oriented Hybrids of Indole and Hydantoin Derivatives

2023

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Indoles and hydantoins are important heterocycles scaffolds which present in numerous bioactive compounds which possess various biological activities. Moreover, they are essential building blocks in organic synthesis, particularly for the preparation of important hybrid molecules. The series of hybrid compounds containing indoles and imidazolidin-2-one moiety with direct С─С bond were synthesized using an amidoalkylation one-pot reaction. All compounds were investigated as a growth regulator for germination, growth and development of wheat seeds (Triticum aestivum L). Their effect on drought resistance at very low concentrations (4 × 10−5 М) was evaluated. The study highlighted identified the leading compounds, 3a and 3e, with higher growth-regulating activity than the indole-auxin analogues.

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Section: Introductionmentioning

confidence: 99%

Biologically Oriented Hybrids of Indole and Hydantoin Derivatives

2023

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“…[21,22] Pyrazole derivatives are considered to be very essential for chemical, pharmaceutical and agricultural industries making these most valuable nitrogen-containing heterocycles. [23][24][25] Pyrazoles have many pharmaceutical properties such as antioxidant, anti-microbial, anti-pyretic, anti-cancer, anti-helmintic, anti-leukemic, anti-depressant, anti-inflammatory, anti-convulsant, anti-oxidant, anti-tubercular, analgesic, anti-proliferative agents, angiogenic, herbicidal properties, etc. [26,27] Pyrazole moiety such as rimonabant suppresses hepatitis B by inhibiting hepatocytes nuclear factor 4α and also acts as powerful antiobesity drug.…”

Section: Introductionmentioning

confidence: 99%

Green Synthesis of Bis(pyrazol‐5‐ole) and Pyrazolopyranopyrimidine Derivatives through Mechanochemistry Using Chitosan as a Biodegradable Catalyst

et al. 2021

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Grinding assisted, simple and green route for the synthesis of bis(pyrazol-5-ole) and pyrazolopyranopyrimidine using chitosan as a biodegradable catalyst is developed. This protocol offers selective synthesis of bis(pyrazol-5-ole) and pyrazolopyranopyrimidine without any side product with excellent yield and shorter duration. Moreover, this method provides metal-free synthesis and put forward easy separation in gram scale synthesis which makes the protocol sustainable. The recyclability of the catalyst is also simple and carried upto eight consecutive runs. In addition, SEM images and powder XRD of fresh and recycled catalysts are also compared.

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“…[ 30–32 ] Similarly, pyrazoles are again a notable five‐membered N ‐fused class with a wide range of biological activities. [ 33 ] Pyrazoles are present in numerous drug molecules such as gastric secretion stimulatory, anti‐inflammatory, antipyretic, antidepressant, antibacterial, antifilarial agent, analgesic, antifungal, antianxiety, and antitumor. [ 34–43 ] In coordination chemistry, pyrazoles as a ligand can differently bond with metals and can also form strong bridge.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and characterization of adenine‐grafted carbon‐modified amorphous ZnO with enhanced catalytic activity

Chowhan

Gupta

Sharma

2020

Applied Organom Chemis

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Sustainability has become a countersign and guiding rule for current field of nanocatalysis. Herein, we report a cost‐effective, greener, clean, and proficient process for the formation of adenine‐grafted carbon‐modified amorphous ZnO nanocatalyst (ZnO@AC) derived from garment industry waste (waste cotton cloth). Due to adenine functionality, catalyst provides consistent dispersion of ZnO providing catalytically active sites for the synthesis of pyrano[2,3‐d]pyrimidines and bis(pyrazol‐5‐ole) and alters the electron–hole pair recombination without notable mass‐transfer limitation. The photocatalytic evaluation of ZnO@AC was performed on methyl orange (MO) dye under UV light and 87.3% degradation efficiency resulted in 75 min. Moreover, the catalyst was recyclable and could be reused up to eight runs, making it more sustainable. The morphology of ZnO@AC remained intact with the slight agglomeration of ZnO nanoparticles (nps) after eight recoveries according to the transmission electron microscopy (TEM) image of the used catalyst.

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Design, synthesis, and antibacterial studies of potent pyrazolinyltriazoles

Cited by 13 publications

References 18 publications

Biologically Oriented Hybrids of Indole and Hydantoin Derivatives

Biologically Oriented Hybrids of Indole and Hydantoin Derivatives

Green Synthesis of Bis(pyrazol‐5‐ole) and Pyrazolopyranopyrimidine Derivatives through Mechanochemistry Using Chitosan as a Biodegradable Catalyst

Fabrication and characterization of adenine‐grafted carbon‐modified amorphous ZnO with enhanced catalytic activity

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