Design, Optimization and in Vitro Characterization of Self Nano Emulsifying Drug Delivery System of Olmesartan Medoxomil

Sisinthy, Sreenivas Patro; Nalamolu, Koteswara Rao; Sarah, Chin Yi Lynn

doi:10.22159/ijpps.2017v9i1.15166

Cited by 13 publications

(12 citation statements)

References 25 publications

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“…Formulation optimization using Box-Behnken experimental design [10] Preparation of nabumetone-loaded nanoemulsion was through mixing the nabumetone, oil, surfactant, cosurfactant and addition of water, with drop by drop gentle stirring at room temperature. After complete dissolution, the nabumetone-loaded nanoemulsion was obtained.…”

Section: Formulation Of Final Screening Batches Of Nanoemulsionmentioning

confidence: 99%

Development and Evaluation of Nanoemulsion as a Carrier for Topical Delivery System by Box-Behnken Design

Chaudhari

Kuchekar²

2018

Asian J Pharm Clin Res

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Objective: The aim of this study was to develop a nanoemulsion for topical delivery. Methods: Topical nanoemulsion was prepared by homogenization method. Box-behnken design was utilized to study the effect of oil, surfactant and Co-surfactant, on droplet size, entrapment efficiency and drug release. Nabumetone a non-steroidal anti-inflammatory drug was incorporated in castor oil with Tween 80 and Polyethylene glycol 600 to form the nanoemulsion by homogenization method. The nanoemulsion was further subjected to different evaluation parameters and ex-vivo study. The crystalline nature of drug was confirmed by powder X-ray diffraction studies. Drug-excipient compatibility was confirmed by Fourier transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC), respectively. Results: The average globule size of nabumetone-containing nanoemulsion decreased with decrease in concentration of oil and surfactant. Nanoemulsion was evaluated by pH, rheology, globule size, zeta potential, scanning electron microscopy, DSC, FTIR spectroscopy, and stability. In vitro drug release shows maximum 84.35% permeation rate through cellophane membrane and ex-vivo drug release shows 86.32% permeation rate through goat skin. Conclusion: Thus, the nanoemulsion formulated showed good results regarding topical delivery.

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Section: Formulation Of Final Screening Batches Of Nanoemulsionmentioning

confidence: 99%

Development and Evaluation of Nanoemulsion as a Carrier for Topical Delivery System by Box-Behnken Design

Chaudhari

Kuchekar²

2018

Asian J Pharm Clin Res

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“…The SNEDDS were diluted with a ratio 1:2500 (v/v) with distilled water and mixed with a magnetic stirrer (Bhikshapathi and Priya, 2018). Zetapotential of the resulting microemulsion was determined using a Zetasizer (Nasr et al, 2016;Sisinthy et al, 2016;Kim et al, 2017).…”

Section: Emulsion Droplet Size Poly Dispersibility Index and Determimentioning

confidence: 99%

Design, Optimization and Evaluation of Snedds Based System for Orlistat: A Quality by Design Approach With 23 Factorial

Vyas

Diwan

Sharma

2020

ijrps

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Obesity, as defined by WHO is an abnormal or excessive fat accumulation that may impair health. is directly proportional to the resultant impact of genetic, metabolic, environment, and culture issues. The leading cause of obesity is an energy imbalance between calories consumed and calories exhausted. To design and optimize SNEDDS formulation by the development of SNEDDS with an appropriate quantity of oil, and with the factorial approach. A series of SNEDDS formulations for was prepared based on solubility studies, pseudo ternary phase diagram and visual observation. was added inaccurately weighed amount of oil into a screw-capped glass vial and heated in a water bath at 40ºC. The and were added to the oily mixture and stirred with a magnetic bar. The formulation was further for 15 minutes and stored at room temperature. From the result of evaluation parameters such as emulsification time 6±1s, % transmittance 94.01±1.5%, drug Loading 99.89%±0.56%, Index 0.47±0.01 and 0.211±0.02, Globulesize99±6 nm, Zeta potential -28.12 and -24.5 , The , Freeze-thaw cycle, Heating-cooling cycle showed no signs of phase separation, Viscosity 132.4±0m Pa.s, drug release 99.25% within 90 minutes, drug release follows Korsmeyer-Peppas model mechanism, n value was found to be1.083 hence it can be postulated formulation F-6 followed the or anomalous release and P-value for factors emulsification time, % transmittance and % drug release was found less than 0.0500 and hence it was concluded formulation F-6 an optimized formulation.

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“…Since celecoxib is a hydrophobic drug; hence, our target was to prepare water in oil nanoemulsion. From the ternary plot, all the possible regions of nanoemulsion formation were estimated [9,17]. Following tables represent the surfactants, co-surfactant (S mix ): Oil:water titration values, which represented in pseudo-ternary plots.…”

Section: Construction Of Pseudo-ternary Plotmentioning

confidence: 99%

“…Formation of various pseudo ternary phase diagram by utilizing the ratio of oil, S mix and water represent the nanoemulsion region and optimized concentration of mixture [17]. The various yellow (Figs.…”

Section: Construction and Outcome Of Pseudo-ternary Diagrammentioning

confidence: 99%

Formulation and Optimization of Celecoxib Nanoemulgel

Bhattacharya

Prajapati

2017

Asian J Pharm Clin Res

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Objective: The main objective of this experiment was to prepare and optimized celecoxib nanoemulgel. This formulation can be used for acute rheumatoid arthritis patients. Methods:Celecoxib is a poorly water soluble drug. We prepared celecoxib nanoemulgel to improve intrinsic solubility of celecoxib and enhance deeper permeation throughout the skin. After several screening, the combination of acetonitrile, triacetin, campul 908P was considered for oil phase; acconon MC8-2EP as surfactant, and capmul MCM C-10 as a co-surfactant accordingly. As per Box-Behnken surface design model, optimization was done for all the 13 formulations.Results: Based on pseudo ternary plot, it was found that 4:1 S mix ratio was optimum and possessed maximum drug solubility. Further, screening shown, 0.25-0.75% carbopol-940 can be a stable candidate for hydrogel preparation. Prepared nanoemulsions and hydrogels were admixed to prepare nanoemulgel. Based on overlay plot, EG14* formulation was consider as optimum one, and various evaluation parameters were performed along with other formulations. Using Franz diffusion cell, in-vitro diffusion studies was performed. Almost all the formulations produces good qualitative drug release profile. The EG14* shown 95.50% drug release after 12 th hrs with standard Higuchi plot (R 2 value 0.9989). The optimum viscosity was found to be 521±0.81 mPas at 100 rpm. The appearance of the formulations was milky, yellowish white with expectable pH ranged from 5.8 to 6.7. The optimized formulation has good spreadability coefficient, good ex-vivo diffusion enhancement factor (3.03) as compare to marketed gel. Mostly, our formulations have less skin irritation and higher anti-inflammatory activity (92.56% of inhibition of paw edema for EG14*). Conclusion:From the thermodynamic studies, it was confirmed that EG14* maintained excellent stability profile in various heating-cooling cycle, centrifugation, and freeze-thaw cycle condition. Hence, it can be conclude that, our formulation, can be consider for pilot scale up.

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Design, Optimization and in Vitro Characterization of Self Nano Emulsifying Drug Delivery System of Olmesartan Medoxomil

Cited by 13 publications

References 25 publications

Development and Evaluation of Nanoemulsion as a Carrier for Topical Delivery System by Box-Behnken Design

Development and Evaluation of Nanoemulsion as a Carrier for Topical Delivery System by Box-Behnken Design

Design, Optimization and Evaluation of Snedds Based System for Orlistat: A Quality by Design Approach With 23 Factorial

Formulation and Optimization of Celecoxib Nanoemulgel

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