Design of Ti6Al4V-HA composites produced by hot pressing for biomedical applications

Miranda, G.; Araújo, Alexandra Maria Dantas de Castro; Bartolomeu, F.; Buciumeanu, M.; Carvalho, Ó.; Souza, Júlio C. M.; Silva, Filipe; Henriques, Bruno

doi:10.1016/j.matdes.2016.07.023

Cited by 62 publications

(45 citation statements)

References 32 publications

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“…In this study, we used 5% hydroxyapatite or β‐TCP to improve the bioactivity of titanium‐based composites without compromise mechanical behavior of the resultant structure . Hydroxyapatite or β‐TCP were gradually incorporated in the composition of the titanium substrate to produce a functionally graded titanium structure leading to the absence of titanium‐ceramic homogeneous interface.…”

Section: Discussionmentioning

confidence: 99%

“…Bioactive ceramic materials have been used to produce titanium/ceramic composites; however, the strategies found in literature are based on homogenous composites with chemical, biological, and mechanical limitations. A few studies have recorded promising mechanical behavior results for functionally graded materials (FGM) by using hot pressing technique . In fact, there is a lack of data on the biological behavior for such novel composites.…”

Section: Introductionmentioning

confidence: 99%

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Bioactivity of novel functionally structured titanium‐ceramic composites in contact with human osteoblasts

Peñarrieta‐Juanito

Costa

Cruz

et al. 2018

J Biomedical Materials Res

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The aim of this study was to analyze the osteogenic cell behavior on the surface of novel functionally graded titanium-based composites containing bioactive ceramics. Titanium grade V discs (8 × 3 mm) embedding gradual content of hydroxyapatite (TiAlV-HA) or beta-tricalcium phosphate (TiAlV-βTCP) were produced by hot-pressing technique. Titanium-ceramic composite discs and Ti grade V (control group) were placed in contact with human osteoblast culture assays. The morphology and adhesion of osteoblasts were inspected by field emission guns scanning electron microscopy (FEGSEM) while cell viability was assessed by fluorometric method. Alkaline phosphatase (ALP) activity and fluorescent microscopic analyses were used to evaluate mineralization on the test and control discs. FEGSEM images showed cells adhered to Ti6Al4V-ceramic and Ti6Al4V surfaces over a period of 24 h, and therefore, an intense proliferation of osteoblasts and spreading cells was noticed for 7 days. Cell viability increased with time on all the surfaces although TiAlV-βTCP revealed significant higher percentage of cell viability than that recorded for TiAlV-HA (p < 0.01). TiAlV-βTCP also showed the highest hydrophilic character. ALP levels increased on the Ti6Al4V-ceramic surfaces when compared to the control group. Also, a qualitative analysis of mineralization evidenced an increase in mineral content on TiAlV-HA or TiAlV-βTCP groups. Novel functionally graded composites based on Ti grade V and hydroxyapatite or βTCP showed a higher bioactivity in presence of osteoblasts than that recorded on Ti grade V. Also, such functionally graded materials can prevent risks of failures by detachment of bioactive ceramic materials during implant placement. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 1923-1931, 2018.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bioactivity of novel functionally structured titanium‐ceramic composites in contact with human osteoblasts

Peñarrieta‐Juanito

Costa

Cruz

et al. 2018

J Biomedical Materials Res

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“…Regarding the additive manufacturing technique, bulk properties of custom‐made root‐analogue implants can be tailored to improve stress distribution decreasing peri‐implant bone loss, and to enhance osseointegration . For instance, an implant structure can be produced within a gradual transition in chemical composition from a compact zirconia at the inner regions of the implants toward to a bioactive and softer material on the outer region . The bioactive materials such as hydroxyapatite enhance the bone healing while adjust the overall stiffness/strength of the implant considering the cortical and trabecular peri‐implant bone elastic modulus .…”

Section: Resultsmentioning

confidence: 99%

Custom‐made root‐analogue zirconia implants: A scoping review on mechanical and biological benefits

et al. 2018

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The aim of this study was to conduct a literature review on the potential benefits of custom-made root-analogue zirconia implants. A PubMed and ScienceDirect bibliographical search was carried out from 1969 to 2017. The increased interest in zirconia-based dental structures linked to aesthetic and biological outcomes have been reported in literature. Recent technological advances have focused on novel strategies for modification of zirconia-based surfaces to accelerate osseointegration. However, only a few studies revealed mechanical and biological benefits of custom-made root-analogue zirconia implants and therefore further studies should investigate the influence of different design and surface modification on the performance of such implants. Custom-made root-analogue zirconia implants have become a viable alternative to overcome limitations concerning stress distribution, aesthetics, and peri-implantitis induced by biofilms. However, further in vitro and in vivo studies on surface-bone interactions and mechanical behavior of zirconia should be evaluated to reduce clinical issues regarding mechanical failures and late peri-implant bone loss. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2888-2900, 2018.

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“…However, with higher loads, as is the case in the present work, it is not clear whether this effect will still be active. It is worth mentioning that the HP manufacturing process maintains the bioactivity of the ceramic bioactive particles, as shown by Miranda et al due to the lower sintering temperatures used in the process …”

Section: Introductionmentioning

confidence: 97%

Effect of HAp and β‐TCP incorporation on the tribological response of Ti6Al4V biocomposites for implant parts

et al. 2017

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Titanium and its alloys have been widely used in many engineering areas due to their properties. Despite having a high implant-tissue osseointegration time, Ti6Al4V has been extensively used in prosthesis and articular implants. To promote a faster bone ingrowth and consequently reduce the implant fixation time, the addition of a bioactive phase to form a biocomposite seems to be an excellent solution. Because of their bioactivity and similarity in composition with the human bone, HAp and β-TCP are two of the most widely used calcium phosphates in biomedical applications. To guarantee a strong adhesion of the previous bioactive materials in the implants surface, samples of Ti6Al4V, Ti6Al4V+HAp (10 vol %) and Ti6Al4V+β-TCP (10 vol %) TCP were processed by the hot pressing technique. Tribological tests against Al O lubricated in PBS at 37°C were carried out on a ball-on-flat reciprocating sliding geometry. Loads in the range of 3 N to 30 N were applied and their effect on the friction behavior and wear resistance of the tested materials was evaluated. Values of the coefficient of friction as well as the wear rate tend to increase with the addition of a bioactive phase to the Ti alloy. Micrographs of the worn surfaces showed that abrasion and plastic deformation are the prevailing wear mechanisms in the studied tribosystems. For biocomposites, particularly in the case of Ti6Al4V+HAp, pull-out of bioactive particle clusters has a determinant role on the tribological response, increasing both the friction coefficient and the specific wear rate. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1010-1016, 2018.

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Design of Ti6Al4V-HA composites produced by hot pressing for biomedical applications

Cited by 62 publications

References 32 publications

Bioactivity of novel functionally structured titanium‐ceramic composites in contact with human osteoblasts

Bioactivity of novel functionally structured titanium‐ceramic composites in contact with human osteoblasts

Custom‐made root‐analogue zirconia implants: A scoping review on mechanical and biological benefits

Effect of HAp and β‐TCP incorporation on the tribological response of Ti6Al4V biocomposites for implant parts

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