Design of porous titanium scaffold for complete mandibular reconstruction: The influence of pore architecture parameters

Dutta, Abir; Mukherjee, Kaushik; Dhara, Santanu; Gupta, Sanjay

doi:10.1016/j.compbiomed.2019.03.004

Cited by 22 publications

(28 citation statements)

References 48 publications

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“…However, due to the stress shielding effect, it was not conducive to the patient’s recovery. Because PEEK has similar mechanical strength to human bones, desirable results were observed in mandibular replacements [ 85 , 153 ].…”

Section: Polymer Materials Of 3d-printed Bone Scaffoldsmentioning

confidence: 99%

Unraveling of Advances in 3D-Printed Polymer-Based Bone Scaffolds

et al. 2022

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The repair of large-area irregular bone defects is one of the complex problems in orthopedic clinical treatment. The bone repair scaffolds currently studied include electrospun membrane, hydrogel, bone cement, 3D printed bone tissue scaffolds, etc., among which 3D printed polymer-based scaffolds Bone scaffolds are the most promising for clinical applications. This is because 3D printing is modeled based on the im-aging results of actual bone defects so that the printed scaffolds can perfectly fit the bone defect, and the printed components can be adjusted to promote Osteogenesis. This review introduces a variety of 3D printing technologies and bone healing processes, reviews previous studies on the characteristics of commonly used natural or synthetic polymers, and clinical applications of 3D printed bone tissue scaffolds, analyzes and elaborates the characteristics of ideal bone tissue scaffolds, from t he progress of 3D printing bone tissue scaffolds were summarized in many aspects. The challenges and potential prospects in this direction were discussed.

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Section: Polymer Materials Of 3d-printed Bone Scaffoldsmentioning

confidence: 99%

Unraveling of Advances in 3D-Printed Polymer-Based Bone Scaffolds

et al. 2022

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“…All fixes limited the degrees of freedom of the corresponding nodes, and all muscle forces were applied equally to the corresponding nodes on the mandibular surface. The values and directions of the normal muscle forces were obtained from relevant research [28,29].…”

Section: Biomechanical Evaluation Of Porous Structuresmentioning

confidence: 99%

Novel Design and Optimization of Porous Titanium Structure for Mandibular Reconstruction

Liu

Yang

et al. 2022

Applied Bionics and Biomechanics

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A porous material is considered to be a potential material that can be used to repair bone defects. However, the methods of designing of a highly porous structure within the allowable stress range remain to be researched. Therefore, this study was aimed at presenting a method for generating a three-dimensional tetrahedral porous structure characterized by low peak stress and high porosity for the reconstruction of mandibular defects. Firstly, the initial tetrahedral porous structure was fabricated with the strut diameters set to 0.4 mm and a mean cell size of 2.4 mm in the design model space. Following this, the simulation analysis was carried out. Further, a homogenization algorithm was used for homogenizing the stress distribution, increasing porosity, and controlling peak stress of the porous structure by adjusting the strut diameters. The results showed that compared with the initial porous structure, the position of the large stress regions remained unchanged, and the peak stress fluctuated slightly in the mandible and fixation system with the optimized porous structure under two occlusions. The optimized porous structure had a higher porosity and more uniform stress distribution, and the maximum stress was lower than the target stress value. The design and optimization technique of the porous structure presented in this paper can be used to control peak stress, improve porosity, and fabricate a lightweight scaffold, which provides a potential solution for mandibular reconstruction.

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“…It was found that octahedron scaffolds exhibited superior static mechanical properties, longer fatigue lives, and higher fatigue strength in comparison to those of tetrahedron ones. It is noteworthy that the porous structure was often built using diamond lattice pore units [200][201][202]. In [126], the Ti-6Al-4V porous scaffolds of two unit cell geometries (reentrant and cubic) fabricated using EBM showed that samples with the cubic unit cell geometries, with struts oriented at an angle of 45 • to the loading direction, and exhibited higher stiffness than samples with the reentrant unit cell geometry at equivalent relative densities.…”

Section: Structural Factors Influencing the Mechanical Propertiesmentioning

confidence: 99%

“…Comparatively, the scaffolds with lesser ID (0.3 mm) resulted in higher stiffness, thereby evoking lower principal strains in the CMC models. Moreover, considering the weight of the scaffolds, the CMC models having 0.3 mm ID with 0.2 mm SD and 0.5 mm ID with 0.6 mm SD is the most appropriate for a patient [201]. In [204], with a fixed strut diameter of 0.45 mm and a mean cell size of 2.2 mm, a tetrahedral structural porous scaffold was designed for a simulated anatomical defect derived from the CT data of a human mandible.…”

Section: Structural Factors Influencing the Mechanical Propertiesmentioning

confidence: 99%

Structural and Material Determinants Influencing the Behavior of Porous Ti and Its Alloys Made by Additive Manufacturing Techniques for Biomedical Applications

Dziaduszewska

Zieliński

2021

Materials

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One of the biggest challenges in tissue engineering is the manufacturing of porous structures that are customized in size and shape and that mimic natural bone structure. Additive manufacturing is known as a sufficient method to produce 3D porous structures used as bone substitutes in large segmental bone defects. The literature indicates that the mechanical and biological properties of scaffolds highly depend on geometrical features of structure (pore size, pore shape, porosity), surface morphology, and chemistry. The objective of this review is to present the latest advances and trends in the development of titanium scaffolds concerning the relationships between applied materials, manufacturing methods, and interior architecture determined by porosity, pore shape, and size, and the mechanical, biological, chemical, and physical properties. Such a review is assumed to show the real achievements and, on the other side, shortages in so far research.

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Design of porous titanium scaffold for complete mandibular reconstruction: The influence of pore architecture parameters

Cited by 22 publications

References 48 publications

Unraveling of Advances in 3D-Printed Polymer-Based Bone Scaffolds

Unraveling of Advances in 3D-Printed Polymer-Based Bone Scaffolds

Novel Design and Optimization of Porous Titanium Structure for Mandibular Reconstruction

Structural and Material Determinants Influencing the Behavior of Porous Ti and Its Alloys Made by Additive Manufacturing Techniques for Biomedical Applications

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