Unraveling of Advances in 3D-Printed Polymer-Based Bone Scaffolds

Xu, Yuanhang; Zhang, Feiyang; Zhai, Weijie; Cheng, Shujie; Li, Jinghua; Wang, Yi

doi:10.3390/polym14030566

Cited by 119 publications

(52 citation statements)

References 176 publications

(196 reference statements)

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“…Apart from this, hydrogels are attracting increasing attention in other research fields for the removal of dyes and ions, sensing, or electronic applications [ 6 , 7 , 8 ]. Since the emergence of 3D printing techniques, leading to shape-defined three-dimensional scaffolds, the development of biocompatible inks constitutes an intensive field of research [ 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Optimization of the Rheological Properties of Self-Assembled Tripeptide/Alginate/Cellulose Hydrogels for 3D Printing

et al. 2022

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3D printing is an emerging and powerful technique to create shape-defined three-dimensional structures for tissue engineering applications. Herein, different alginate–cellulose formulations were optimized to be used as printable inks. Alginate (Alg) was chosen as the main component of the scaffold due to its tunable mechanical properties, rapid gelation, and non-toxicity, whereas microcrystalline cellulose (MCC) was added to the hydrogel to modulate its mechanical properties for printing. Additionally, Fmoc-FFY (Fmoc: 9-fluorenylmethoxycarbonyl; F: phenylalanine; Y: tyrosine), a self-assembled peptide that promotes cell adhesion was incorporated into the ink without modifying its rheological properties and shear-thinning behavior. Then, 3D-printed scaffolds made of Alg, 40% of MCC inks and Fmoc-FFY peptide were characterized by scanning electron microscopy and infrared spectroscopy, confirming the morphological microstructure of the hydrogel scaffolds with edged particles of MCC homogeneously distributed within the alginate matrix and the self-assembly of the peptide in a β-sheet conformation. Finally, the cytocompatibility of the scaffolds was tested in contact with the MG63 osteosarcoma cells, confirming the absence of cytotoxic components that may compromise their viability. Interestingly, MG63 cell growth was retarded in the scaffolds containing the peptide, but cells were more likely to promote adhesive interactions with the material rather than with the other cells, indicating the benefits of the peptide in promoting biological functionality to alginate-based biomaterials.

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Section: Introductionmentioning

confidence: 99%

Optimization of the Rheological Properties of Self-Assembled Tripeptide/Alginate/Cellulose Hydrogels for 3D Printing

et al. 2022

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“… Printed bone scaffolds can replace the bone and cartilage defects in rat and rabbit, ( a ) regeneration of skull defect in rats; ( b ) articular cartilage regeneration in rabbits. Reproduced from [ 54 ] which is licensed under a Creative Commons Attribution-(CC BY 4.0) International License ( , accessed on 17 April 2022). …”

Section: Figurementioning

confidence: 99%

Recent Advances in 3D Bioprinting: A Review of Cellulose-Based Biomaterials Ink

et al. 2022

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Cellulose-based biodegradable hydrogel proves to be excellently suitable for the medical and water treatment industry based on the expressed properties such as its flexible structure and broad compatibility. Moreover, their potential to provide excellent waste management from the unutilized plant has triggered further study on the advanced biomaterial applications. To extend the use of cellulose-based hydrogel, additive manufacturing is a suitable technique for hydrogel fabrication in complex designs. Cellulose-based biomaterial ink used in 3D bioprinting can be further used for tissue engineering, drug delivery, protein study, microalgae, bacteria, and cell immobilization. This review includes a discussion on the techniques available for additive manufacturing, bio-based material, and the formation of a cellulose-based hydrogel.

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“…3D bioprinting is a technology derived from 3D printing that creates complex geometries from 3D digital models generated by computer-aided design (CAD) software, which allows precise regulation of the size and structure of biological scaffolds by printing according to a preset program ( Xu et al, 2022 ). In the manufacture of cartilage scaffolds, this emerging technology enables the production of AC scaffolds with controlled structure and porosity, and the ability to precisely tune the geometry and mechanical properties of the scaffold ( Dai et al, 2020 ).…”

Section: Technologies For Artificial Ac With Scaffoldmentioning

confidence: 99%

Novel advances in strategies and applications of artificial articular cartilage

Chen

Zhang²,

Zhang³

et al. 2022

Front. Bioeng. Biotechnol.

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Artificial articular cartilage (AC) is extensively applied in the repair and regeneration of cartilage which lacks self-regeneration capacity because of its avascular and low-cellularity nature. With advances in tissue engineering, bioengineering techniques for artificial AC construction have been increasing and maturing gradually. In this review, we elaborated on the advances of biological scaffold technologies in artificial AC including freeze-drying, electrospinning, 3D bioprinting and decellularized, and scaffold-free methods such as self-assembly and cell sheet. In the following, several successful applications of artificial AC built by scaffold and scaffold-free techniques are introduced to demonstrate the clinical application value of artificial AC.

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Unraveling of Advances in 3D-Printed Polymer-Based Bone Scaffolds

Cited by 119 publications

References 176 publications

Optimization of the Rheological Properties of Self-Assembled Tripeptide/Alginate/Cellulose Hydrogels for 3D Printing

Optimization of the Rheological Properties of Self-Assembled Tripeptide/Alginate/Cellulose Hydrogels for 3D Printing

Recent Advances in 3D Bioprinting: A Review of Cellulose-Based Biomaterials Ink

Novel advances in strategies and applications of artificial articular cartilage

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