Design of metal–organic framework composites in anti-cancer therapies

Zheng, Yadan; Zhang, Xiaoyuan; Su, Zhiqiang

doi:10.1039/d1nr02581c

Cited by 26 publications

(14 citation statements)

References 120 publications

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“…MOFs were combined with inorganic materials to enhance their unique properties. Nevertheless, it is important to look into the specifics of their relationship [10]. Inorganic nanoparticles, which are frequently used, control the tumour's location's photothermal effect [10].…”

Section: Mofs As Biomarkersmentioning

confidence: 99%

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Application of Zn-MOFs in Treating Cancer

Zhang¹

2023

HSET

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Metal-organic frameworks (MOFs) are extremely porous crystals belonging to metallic complexes, made up of metal ions or clusters and organic ligands via coordinative bonding. The construction of tailored MOFs has attracted increasing interest over the past few decades. Particularly, a variety of applications for the delivery of drugs using MOFs are being investigated. MOFs were initially employed to deliver small-molecule medications. In this article, the construction of electrochemical (EC) biosensors based on MOFs that are directed toward certain analytes are mainly introduced. The classification of MOFs for drug-delivery systems (DDSs) based on the types of constitutes is presented in this article as an overview and point of view of MOF-based DDSs, among which, Zn-based MOFs are one of the best choices to be used in cancer treatment. This article demonstrates the advantages of Zn-based MOFs in cancer treatment compared to their counterparts.

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Section: Mofs As Biomarkersmentioning

confidence: 99%

“…Nevertheless, it is important to look into the specifics of their relationship [10]. Inorganic nanoparticles, which are frequently used, control the tumour's location's photothermal effect [10]. The colour of bimetallic ZIF nanoparticles darkens as the Co concentration rises.…”

Section: Mofs As Biomarkersmentioning

confidence: 99%

Application of Zn-MOFs in Treating Cancer

Zhang¹

2023

HSET

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“…Since Horcajada et al tested MOFs as drug delivery systems (DDS) for the first time in 2008, there have been consistent efforts to improve their efficacy by devising strategies to avoid possible drug leakage (Horcajada et al, 2008;Pandey et al, 2020). Several MOFs have been developed in recent years as DDS for tumor therapy (Zheng et al, 2021). Nevertheless, the poor biocompatibility of MOFs is a major obstacle to their clinical translation (Chen et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Multi-stimuli responsive Cu-MOFs@Keratin drug delivery system for chemodynamic therapy

Chen

Yuan

et al. 2023

Front. Bioeng. Biotechnol.

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Although the potential of metal-organic framework (MOF) nanoparticles as drug delivery systems (DDS) for cancer treatment has been established by numerous studies, their clinical applications are still limited due to relatively poor biocompatibility. We fabricated a multifunctional Cu-MOFs@Keratin DDS for loaded drug and chemodynamic therapy (CDT) against tumor cells. The Cu-MOFs core was prepared using a hydrothermal method, and then loaded with the anticancer drug DOX and wrapped in human hair keratin. The Cu-MOFs@Keratin was well characterized by transmission electron microscopy (TEM), fourier transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), and X-ray photoelectron spectroscopy (XPS). Characterization and pharmacokinetic studies of Cu-MOFs@Keratin were performed in vitro and in vivo. The keratin shell reduced the cytotoxicity and potential leakage of Cu-MOFs to normal cells, and allowed the drug-loaded nanoparticles to accumulate in the tumor tissues through enhanced permeability and retention effect (EPR). The particles entered the tumor cells via endocytosis and disintegrated under the stimulation of intracellular environment, thereby releasing DOX in a controlled manner. In addition, the Cu-MOFs produced hydroxyl radicals (·OH) by consuming presence of high intracellular levels of glutathione (GSH) and H2O2, which decreased the viability of the tumor cells.

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“…Owing to the characteristic of abundant pore structures, multiple functional ligands and metalorganic frameworks (MOFs) attract growing attention as catalytic and drug carriers in nanomedicine applications. 20,21 The MOFs have been designed to conform to the requirements of high biosafety and the ability to carry drugs in vivo. 22 There were many pieces of research about stimuli-responsive MOFs nanoparticles, which were used for the controlled release of drugs and biomedical applications of therapeutics.…”

Section: Introductionmentioning

confidence: 99%