Precision therapy through breaking the intracellular redox balance with an MOF-based hydrogel intelligent nanobot for enhancing ferroptosis and activating immunotherapy

Abstract

With the advancement and development of nanomedicine, tumor precision therapy provides technical support for effective accumulation, targeted drug delivery, and reduces toxic side effects. In cancer cells, breaking the redox...

Nanoscale metallic‐organic frameworks as an advanced tool for medical applications: Challenges and recent progress

“…In the presence of GSH, the disulfide links of the MOF broke down, leading to the release of the drug. Zhang et al [ 52 ] fabricated a novel smart MOF‐based complex comprising Chlorin e6 (Ce6) an as anticancer drug. In the acidic tumor environment, highly toxic hydroxyl radicals are generated via Fenton reaction.…”

Precisely designed Fex (x = 1–2) cluster nanocatalysts for effective nanocatalytic tumor therapy

“…4i, it was found that the mitochondria gradually shrunk after the incubation with Fe 2 @TDF, which was one of the signs of ferroptosis. 36,43,44 Moreover, it has been reported that the depletion of GSH will cause the inactivation of GPX4, resulting in the acceleration of lipid peroxidation. The western blot assay was also applied to determine the expression of the GPX4 protein under different conditions.…”

Recent advances in nanoscale metal–organic frameworks for cancer chemodynamic therapy

“…In vivo: the tumor inhibition effect of the M@C2G or C2 group was relatively weak, while in stark contrast, the C1@M@C2G group significantly inhibited tumor growth (exact data not shown). FeSe 2 −Ce6/MOF@HA/PEI/CpG@HHPA (FSMH) nanoplatform that enables precise combination strategy effects for CDT, PDT, and immunotherapy 72 (Fig. 6c).…”

“…as organic linkers, some studies incorporate the photosensitizers into the highly porous structure of MOF to play effective PDT. Zheng and co-workers fabricated a size controllable and environment-adaptive smart FeSe 2 −Ce6/MOF@HA/PEI/CpG@HHPA (FSMH) nanoplatform that enables precise combination strategy effects for CDT, PDT, and immunotherapy 72 (Fig. 6c).…”