Application of Zn-MOFs in Treating Cancer

Abstract

Metal-organic frameworks (MOFs) are extremely porous crystals belonging to metallic complexes, made up of metal ions or clusters and organic ligands via coordinative bonding. The construction of tailored MOFs has attracted increasing interest over the past few decades. Particularly, a variety of applications for the delivery of drugs using MOFs are being investigated. MOFs were initially employed to deliver small-molecule medications. In this article, the construction of electrochemical (EC) biosensors based on MOFs that are directed toward certain analytes are mainly introduced. The classification of MOFs for drug-delivery systems (DDSs) based on the types of constitutes is presented in this article as an overview and point of view of MOF-based DDSs, among which, Zn-based MOFs are one of the best choices to be used in cancer treatment. This article demonstrates the advantages of Zn-based MOFs in cancer treatment compared to their counterparts.