Design of calcium phosphate ceramics for drug delivery applications in bone diseases: A review of the parameters affecting the loading and release of the therapeutic substance

Parent, Marianne; Baradari, Hiva; Champion, Éric; Damia, Chantal; Viana-Trecant, Marylène

doi:10.1016/j.jconrel.2017.02.012

Cited by 129 publications

(82 citation statements)

References 145 publications

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“…When the concentration of paracetamol was 4 mg L −1 , a maximum loading capacity of 5.00 mg mg −1 was attained, and remained constant even though concentration of paracetamol was further increased to 10 mg L −1 . The drug‐loading capacity plateau could be attributed to the saturation of the adsorption sites of starch‐citrate nanoparticles …”

Section: Resultsmentioning

confidence: 99%

pH‐Responsive Starch‐Citrate Nanoparticles for Controlled Release of Paracetamol

et al. 2019

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Starch‐citrate samples with degrees of substitution (DS) ranging from 0.11 to 0.90 are synthesized by a green esterification reaction between citric acid and native sago starch (Metroxylon sagu) in an aqueous medium. Starch‐citrate nanoparticles with mean diameter of 105 nm are subsequently obtained by controlled precipitation through drop‐wise addition of dissolved starch‐citrate solution into excess absolute ethanol. These nanoparticles are observed to exhibit pH‐responsive release profiles within the physiological pH range of 1.2–8.6. The release profile of a model drug (paracetamol) is observed to obey the zero‐order kinetics, with the release mechanism based on the diffusion and swelling model. The cytotoxicity study in HaCaT cell lines (human skin cells) shows that starch‐citrate nanoparticles are non‐toxic and hence are suitable for biomedical applications as pH‐responsive drug carriers.

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Section: Resultsmentioning

confidence: 99%

pH‐Responsive Starch‐Citrate Nanoparticles for Controlled Release of Paracetamol

et al. 2019

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“…As técnicas associadas ao uso de vácuo têm sido descritas como eficientes na incorporação de substâncias na superfície e também na porosidade de biomateriais de fosfato de cálcio [16,19,31]. Entretanto, o tipo de interação entre o fármaco e a matriz, se fisio ou quimiossorção, influencia tanto o processo de carregamento quanto o comportamento de liberação, in vivo ou in vitro [16,17]. Assim, são necessários estudos posteriores de liberação in vitro do sistema formado pela matriz bifásica de fosfato de cálcio-carboplatina produzida neste trabalho para melhor elucidar o tipo de interação formada.…”

Section: Discussionunclassified

“…Na oncologia, diversos estudos são realizados com o uso de biomateriais nanoestruturado de fosfatos de cálcio em tratamento de tumores na estrutura óssea. Os resultados mostram que esses biomateriais apresentam comportamento eficiente na entrega de fármacos in situ [14][15][16][17].…”

Section: Introductionunclassified

Carregamento e caracterização do fármaco carboplatina na microestrutura microporosa do biomaterial granulado bifásico micro e nanoestruturado de fosfato de cálcio

et al. 2019

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RESUMO As biocerâmicas bifásicas hidroxiapatita/fosfato tricálcico-beta (HA/TCP-β) microporosas são pesquisadas e se destacam em aplicações biomédicas como substitutos dos tecidos ósseos. Estes biomateriais são biocompatíveis e apresentam microestruturas microporosas interconectadas, que permitem sua utilização no reparo do tecido ósseo. Devido às suas características microestruturais, estes biomateriais vem sendo também avaliados para liberação controlada de fármacos. O presente trabalho teve como objetivo a incorporação do fármaco carboplatina no biomaterial granulado bifásico microporoso 60%HA/40%TCP-β pelo método de alto vácuo e caracterização do biomaterial carregado, nas concentrações de 1, 5, 10 e 20 mg/g de carboplatina no biomaterial. Os resultados apresentados envolvem a caracterização morfológica, microestrutural, cristalográfica e química do biomaterial granulado bifásico microporoso. A microscopia eletrônica de varredura (MEV) mostrou em suas micrografias a presença dos precipitados de carboplatina na microestrutura microporosa do biomaterial. O resultado da difratometria de raios X (DRX) permitiu a identificação dos picos representativos da fase cristalina da HA, TCP-β e da carboplatina depois do carregamento. A análise por espectroscopia na região do infravermelho (FTIR) evidenciou os modos vibracionais relativos aos fosfatos de cálcio, OH-e PO43-e também Pt-N e NH3 da molécula da carboplatina. Os resultados obtidos demonstraram que a microporosidade da biocerâmica e o método de alto vácuo possibilitaram o carregamento da carboplatina na microestrutura do biomaterial granulado.

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“…The chemical formula of stoichiometric HAp is Ca 10 (PO 4 ) 6 (OH) 2 with a Ca/P ratio of 1.67 and properties including solubility, bioactivity, osseointegration, and osteoinduction [1,24]. By changing the Ca/P ratio, several calcium phosphates can be obtained [29,30]. The properties of HAp can significantly affect the particle composition, assembly, size, and morphology.…”

Section: Hydroxyapatite Nanoparticlesmentioning

confidence: 99%

Hydroxyapatite Nanoparticle Coating on Polymer for Constructing Effective Biointeractive Interfaces

Galindo

Chai

Tagaya

2019

Journal of Nanomaterials

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Bone is an organic-inorganic composite with the ability to regenerate itself. Thus, several studies based on artificial organic-inorganic interface sciences have been tried to develop capable materials for effective regenerative bone tissues. Hydroxyapatite nanoparticles (HAp NPs) have extensively been researched in bone tissue engineering due to the compositional and shape similarity to the mineral bone and excellent biocompatibility. However, HAp alone has low mechanical strength, which limits its applications. Therefore, HAp NPs have been deposited on the biocompatible polymer matrix, obtaining composites with the enhanced mechanical, thermal, and rheological properties and with higher biocompatibility and bioactivity. For developing new biomedical applications, polymer-HAp interfacial interactions that provide biofusion should be investigated. This paper reviewed common coating techniques for obtaining HAp NPs/polymer fusion interfaces as well as in vitro studies of interfacial interactions with proteins and cells, demonstrating better biocompatibility. Studies based on interfacial interactions between biomolecules and HAp NPs were highlighted, and how these interactions can be affected by specific protein preadsorption was also summarized.

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Design of calcium phosphate ceramics for drug delivery applications in bone diseases: A review of the parameters affecting the loading and release of the therapeutic substance

Cited by 129 publications

References 145 publications

pH‐Responsive Starch‐Citrate Nanoparticles for Controlled Release of Paracetamol

pH‐Responsive Starch‐Citrate Nanoparticles for Controlled Release of Paracetamol

Carregamento e caracterização do fármaco carboplatina na microestrutura microporosa do biomaterial granulado bifásico micro e nanoestruturado de fosfato de cálcio

Hydroxyapatite Nanoparticle Coating on Polymer for Constructing Effective Biointeractive Interfaces

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