Hydroxyapatite Nanoparticle Coating on Polymer for Constructing Effective Biointeractive Interfaces

Galindo, Tania Guadalupe Peñaflor; Chai, Yadong; Tagaya, Motohiro

doi:10.1155/2019/6495239

Cited by 53 publications

(30 citation statements)

References 244 publications

(267 reference statements)

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“…In this sense, biomaterials can be categorized into polymers, liposomes, micelles, dendrimers, and calcium phosphate (CaP) nanoparticles, where each will show a different type of bioactivity [ 3 ]. Bioceramics are known for their high biocompatibility, high chemical stability, and high mechanical strength in vivo [ 4 , 5 ]. Hydroxyapatite (HAP), chemically known as Ca 10 (PO 4 ) 6 (OH) 2 , is a biocompatible, osteoconductive, and bioactive ceramic with the ability to form direct bonds with living tissues [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Hydroxyapatite Nanoparticles in Drug Delivery: Physicochemistry and Applications

2021

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Hydroxyapatite (HAP) has been the gold standard in the biomedical field due to its composition and similarity to human bone. Properties such as shape, size, morphology, and ionic substitution can be tailored through the use of different synthesis techniques and compounds. Regardless of the ability to determine its physicochemical properties, a conclusion for the correlation with the biological response it is yet to be found. Hence, a special focus on the most desirable properties for an appropriate biological response needs to be addressed. This review provides an overview of the fundamental properties of hydroxyapatite nanoparticles and the characterization of physicochemical properties involved in their biological response and role as a drug delivery system. A summary of the main chemical properties and applications of hydroxyapatite, the advantages of using nanoparticles, and the influence of shape, size, functional group, morphology, and crystalline phase in the biological response is presented. A special emphasis was placed on the analysis of chemical and physical interactions of the nanoparticles and the cargo, which was explained through the use of spectroscopic and physical techniques such as FTIR, Raman, XRD, SEM, DLS, and BET. We discuss the properties tailored for hydroxyapatite nanoparticles for a specific biomolecule based on the compilation of studies performed on proteins, peptides, drugs, and genetic material.

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Section: Introductionmentioning

confidence: 99%

Hydroxyapatite Nanoparticles in Drug Delivery: Physicochemistry and Applications

2021

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“…Tumor angiogenesis supports the oxygen supply and essential nutrients for tumor growth as well as allows for metastasis of tumor cells to distant sites [ 10 , 11 ]. Accordingly, tumor angiogenesis has been one of the primary targets in cancer treatment and, indeed, many anti-angiogenic drugs have been discovered and introduced to clinical practice [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

BSA-Silver Nanoparticles: A Potential Multimodal Therapeutics for Conventional and Photothermal Treatment of Skin Cancer

et al. 2021

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Silver nanoparticles (NPs) have attracted a considerable interest in the field of cancer research due to their potential utility in cancer therapy. In the present study, we developed bovine serum albumin (BSA)-coated silver NPs (BSA-Silver NPs) and characterized in vitro multimodal therapeutic activities of NPs for the treatment of skin cancer. BSA-Silver NPs were synthesized by a single-step reduction process, and the successful preparation was verified through a list of physical characterizations, including transmission electron microscopy (TEM), ultraviolet-visible (UV–VIS) light spectroscopy, dynamic light scattering (DLS), and Fourier transform infrared (FT-IR) spectroscopy. The synthesized BSA-Silver NPs showed marked cytocidal effects on B16F10 melanoma cells, which was likely caused by oxidative stress. BSA-Silver NPs also elicited significant anti-angiogenic effects on HUVEC (human umbilical vein endothelial cell) by inhibiting their proliferation, migration, and tube formation. Moreover, BSA-Silver NPs showed a considerable light-to-heat conversion ability, suggesting their utility as photothermal agents. Overall, our findings suggest that BSA-Silver NPs may be promising candidates for the multimodal therapy of skin cancer.

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“…Indeed, nHA exists in the human bone in the form of nanometer-sized threads, thus ensuring biocompatibility. At present, it is mostly used to produce surface coatings, as its biomimetic mineralization enables the production of biomaterials with biomimetic compositions and hierarchical micro/nanostructures that closely mimic the extracellular matrix of native bone tissue [ 34 , 35 ].…”

Section: Introductionmentioning

confidence: 99%

Assessment of the Mechanical and Thermal Properties of Injection-Molded Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)/Hydroxyapatite Nanoparticles Parts for Use in Bone Tissue Engineering

et al. 2020

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In the present study, poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) [P(3HB-co-3HHx)] was reinforced with hydroxyapatite nanoparticles (nHA) to produce novel nanocomposites for potential uses in bone reconstruction. Contents of nHA in the 2.5–20 wt % range were incorporated into P(3HB-co-3HHx) by melt compounding and the resulting pellets were shaped into parts by injection molding. The addition of nHA improved the mechanical strength and the thermomechanical resistance of the microbial copolyester parts. In particular, the addition of 20 wt % of nHA increased the tensile (Et) and flexural (Ef) moduli by approximately 64% and 61%, respectively. At the highest contents, however, the nanoparticles tended to agglomerate, and the ductility, toughness, and thermal stability of the parts also declined. The P(3HB-co-3HHx) parts filled with nHA contents of up to 10 wt % matched more closely the mechanical properties of the native bone in terms of strength and ductility when compared with metal alloys and other biopolymers used in bone tissue engineering. This fact, in combination with their biocompatibility, enables the development of nanocomposite parts to be applied as low-stress implantable devices that can promote bone reconstruction and be reabsorbed into the human body.

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Hydroxyapatite Nanoparticle Coating on Polymer for Constructing Effective Biointeractive Interfaces

Cited by 53 publications

References 244 publications

Hydroxyapatite Nanoparticles in Drug Delivery: Physicochemistry and Applications

Hydroxyapatite Nanoparticles in Drug Delivery: Physicochemistry and Applications

BSA-Silver Nanoparticles: A Potential Multimodal Therapeutics for Conventional and Photothermal Treatment of Skin Cancer

Assessment of the Mechanical and Thermal Properties of Injection-Molded Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)/Hydroxyapatite Nanoparticles Parts for Use in Bone Tissue Engineering

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