Design of biosensor array with current boost and signal conditioning circuits for HPV detection

Gopinath, P.; Anitha, V. R.; Mastani, S. Aruna

doi:10.1016/j.aej.2017.01.012

Cited by 8 publications

(6 citation statements)

References 16 publications

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“…Later, anthraquinone-labelled pyrrolidinyl peptide nucleic acid (acpcPNA) probe (AQ-PNA) was immobilized onto the electrode surface to detect 14 bp synthetic oligonucleotide sequence like HPV DNA using square-wave voltammetry. In another study, Gopinath and colleagues developed a carbon nanotube FET (CNTFET) based biosensor for the detection of HPV infections in early stages ( Gopinath et al, 2018 ). Here, HPV DNA probe was deposited onto the CNT thin film via 3-aminopropyltriethoxysilane (APTES) to improve the current ratings.…”

Section: Iomt-assisted Poc Biosensing For Infectious Diseasesmentioning

confidence: 99%

Internet of medical things (IoMT)-integrated biosensors for point-of-care testing of infectious diseases

Jain

Nehra

Kumar

et al. 2021

Biosensors and Bioelectronics

242

155

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On global scale, the current situation of pandemic is symptomatic of increased incidences of contagious diseases caused by pathogens. The faster spread of these diseases, in a moderately short timeframe, is threatening the overall population wellbeing and conceivably the economy. The inadequacy of conventional diagnostic tools in terms of time consuming and complex laboratory-based diagnosis process is a major challenge to medical care. In present era, the development of point-of-care testing (POCT) is in demand for fast detection of infectious diseases along with “on-site” results that are helpful in timely and early action for better treatment. In addition, POCT devices also play a crucial role in preventing the transmission of infectious diseases by offering real-time testing and lab quality microbial diagnosis within minutes. Timely diagnosis and further treatment optimization facilitate the containment of outbreaks of infectious diseases. Presently, efforts are being made to support such POCT by the technological development in the field of internet of medical things (IoMT). The IoMT offers wireless-based operation and connectivity of POCT devices with health expert and medical centre. In this review, the recently developed POC diagnostics integrated or future possibilities of integration with IoMT are discussed with focus on emerging and re-emerging infectious diseases like malaria, dengue fever, influenza A (H1N1), human papilloma virus (HPV), Ebola virus disease (EVD), Zika virus (ZIKV), and coronavirus (COVID-19). The IoMT-assisted POCT systems are capable enough to fill the gap between bioinformatics generation, big rapid analytics, and clinical validation. An optimized IoMT-assisted POCT will be useful in understanding the diseases progression, treatment decision, and evaluation of efficacy of prescribed therapy.

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Section: Iomt-assisted Poc Biosensing For Infectious Diseasesmentioning

confidence: 99%

Internet of medical things (IoMT)-integrated biosensors for point-of-care testing of infectious diseases

Jain

Nehra

Kumar

et al. 2021

Biosensors and Bioelectronics

242

155

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“…CNT-based virus biosensors relying on DPV exhibit very high recovery in complex media such as serum 109,125 and cells. 112 CNTs have also been introduced to FET, 129,135,142,144 chemiresistors, 132,133 volumetric assays, 123 optical sensors 136 as well as conventional techniques for viral genome recognition such as PCR 145,146 and loop-mediated isothermal amplification (LAMP). 113 Reverse transcription LAMP-based HIV-1 DNA detection using carboxylated CNTs is even faster than fluorescent PCR and shows a 96.5% concordance rate with Roche instruments and a Nernstian response factor of 63.567 mV pH À1 .…”

Section: Carbon Allotrope-based Nanomaterials In Virus Sensing and Tr...mentioning

confidence: 99%

“…CNT functionalized electrodes can be easily conjugated with various receptors such as aptamers, 123,124 molecularly imprinted polymers (MIPs), 124,125 proteins 109,123,[126][127][128] as well as nucleic acids (Table 1). [111][112][113] Several different coupling chemistries such as cysteamine, 126 ethyl(dimethylaminopropyl) carbodiimide (EDC) with N-hydroxysuccinimide (NHS), 109,123,127 (3-aminopropyl) triethoxysilane (APTES), 123 and glutaraldehyde 129 have been explored to conjugate CNTs with receptors. Choice of a receptor as well as the chemistry employed for its immobilization play a critical role in the sensing properties.…”

Section: Carbon Allotrope-based Nanomaterials In Virus Sensing and Tr...mentioning

confidence: 99%

Nanomaterials for virus sensing and tracking

Pirzada

Altıntaş

2022

Chem. Soc. Rev.

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“…CNT‐FET devices are now commonly used in research in the detection of inorganic molecules, DNA and biological proteins (Artyukhin et al, 2006). They have been shown capable to directly interact with neuroglial cells in culture and detect the release of ATP from the cells (Huang et al, 2009) as well as be targeted to the detection of specific cancer antigens allowing the detection of HPV (Gopinath et al, 2018). Some groups have shown biocompatibility can be achieved through the functionalization of the CNTs with monosaccharides (Sudibya et al, 2009) or by encapsulating the channel in a lipophilic membrane, thereby overcoming any toxicity (Joshi, Bhatt, Jaworska, et al, 2018) which has also been shown to have an anti‐fouling effect on the FET device allowing for the detection of molecules in even complex, biologically relevant solutions (Chen et al, 2018).…”

Section: Understanding Biology Using Nanowiresmentioning

confidence: 99%

Toward nanobioelectronic medicine: Unlocking new applications using nanotechnology

Gibney

Hicks

Robinson

et al. 2021

WIREs Nanomed Nanobiotechnol

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Bioelectronic medicine aims to interface electronic technology with biological components and design more effective therapeutic and diagnostic tools. Advances in nanotechnology have moved the field forward improving the seamless interaction between biological and electronic components. In the lab many of these nanobioelectronic devices have the potential to improve current treatment approaches, including those for cancer, cardiovascular disorders, and disease underpinned by malfunctions in neuronal electrical communication. While promising, many of these devices and technologies require further development before they can be successfully applied in a clinical setting. Here, we highlight recent work which is close to achieving this goal, including discussion of nanoparticles, carbon nanotubes, and nanowires for medical applications. We also look forward toward the next decade to determine how current developments in nanotechnology could shape the growing field of bioelectronic medicine. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Diagnostic Tools > Biosensing

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Design of biosensor array with current boost and signal conditioning circuits for HPV detection

Cited by 8 publications

References 16 publications

Internet of medical things (IoMT)-integrated biosensors for point-of-care testing of infectious diseases

Internet of medical things (IoMT)-integrated biosensors for point-of-care testing of infectious diseases

Nanomaterials for virus sensing and tracking

Toward nanobioelectronic medicine: Unlocking new applications using nanotechnology

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